Richard Leiacker

Temperature profile in the nasal cavity.

Objectives/Hypothesis Inspired air is heated and moistened as it passes the nasal cavity. The temperature increase should be similar to a heated tube model, depending on the airflow.

Impact of unilateral sinus surgery with resection of the turbinates by means of midfacial degloving on nasal air conditioning.

Objective/Hypothesis One of the most important functions of the nose is the climatization of inspired air. The aim of the investigation was to determine the influence of radical sinus surgery with complete resection of the turbinates and the lateral nasal wall by means of midfacial degloving as treatment for inverted papilloma on the nasal humidification and heating of inspired air.

Tracheal climate in laryngectomees after use of a heat and moisture exchanger.

Objective/Hypothesis: Heat and moisture exchangers (HME) are frequently used in the treatment and prevention of tracheobronchial dryness and infections. In this study, the short‐term influence of the HME Prim‐Air System (Heimomed, Kerpen, Germany) in laryngectomized patients was tested.

The relationship between water vapour saturation of inhaled air and nasal patency.

The nasal cavity volume and the temperature of the nasal mucosa are considered to be the most important predictors of nasal conditioning. The aim of this study was to assess the relationship between the intranasal degree of water vapour saturation of inhaled air and nasal patency. Intranasal humidity values at different locations within the nasal cavity of 15 healthy subjects were compared to nasal airway resistance detected by active anterior rhinomanometry (AAR). Repeated measurements were carried out during one day to obtain varying nasal cavity volumes due to the nasal cycle. The end-inspiratory humidity data were obtained with a miniaturised capacitive humidity sensor at defined detection sites within the anterior nasal segment without interruption of nasal breathing. Measurements were carried out at four different times during one day. The degree of water vapour saturation did not correlate with the values of the AAR at any intranasal detection site and time of detection during one day. The study supports the view that there is no correlation between the degree of water vapour saturation within the anterior nasal segment and the nasal resistance during the nasal cycle over the day. Although nasal patency varies because of the nasal cycle, the changes of nasal cavity volume due to the nasal cycle do not seem to influence the degree of water vapour saturation of the inspiratory air.

Nasal mucosal temperature after exposure to cold, dry air and hot, humid air.

Objective - To determine the influence of variations in the temperature and humidity of inhaled air on the nasal mucosal temperature at various sites int he nasal airways. Materials and Methods - Fifteen volunteers were enrolled int he study. The temperature was measured on the mucosal surface of the nasal septum at the level of the nasal vestibule, in the nasal valve area, anterior turbinate area and choanae. Temperature measurements were made using a miniaturized thermocouple. Continuous temperature readings were performed before and after 10 min of exposure to either cold, dry air, ambient air or hot, humid air. Results - Inhilation of cold, dry air significantly reduced the temperatyre of the septal mucosa at each location of measurement compared to the breathing of ambient air. Inhalation of hot, humid air significantly increased the septal mucosal temperature at all detection sites. Conclusions - The climatic condition of inhaled air can lead to significant changes in nasal mucosal temperature. As the nasal mucosa is important for nasal air conditioning, short term exposure to air of extreme temperature and humidity can rapidly compromise nasal air conditioning.

Nasal conditioning in perennial allergic rhinitis after nasal allergen challenge

Background Antigen challenge in seasonal allergic rhinitis is considered to be associated with an increased ability of the nose to condition inspired air. In contrast, little is known about air conditioning after antigen challenge in perennial allergic rhinitis (PAR).

Nasal mucosal temperature in relation to nasal airflow as measured by rhinomanometry.

Background The aim of this study was to measure in vivo nasal mucosal temperature and assess its relationship to nasal patency. Methods Nasal mucosal temperature of 30 nasal cavities was measured by means of a miniaturized thermocouple within the anterior turbinate area during respiration. Temperature values were compared with corresponding rhinomanometrical data. Results The median mucosal temperature ranged from 30.2°C (range, 28.9–31.7°C) after inspiration to 32.2°C (range, 31.0–33.9°C) after expiration. The end-inspiratory (r = -0.85) and end-expiratory mucosal temperature values (r = -0.88) negatively correlated with the rhinomanometrical data. Conclusion This study supports the fact that there is a negative correlation between nasal mucosal temperature and nasal resistance. Changes in nasal patency seem to influence nasal mucosal temperature. Within this context, nasal thermoreceptors might play an important role concerning the perception of nasal patency.

Detection of particles within the nasal airways during respiration

Abstract This study introduces a new experimental set-up for particle detection within the nasal airways and describes intranasal deposition of particles at various regions of the nasal cavity and the nasopharynx. During respiration of an aerosol of starch particles the nondeposited particles in the air were detected in 11 volunteers by a transnasally placed suction probe at numerous sites of the nasal cavity and nasopharynx. Another, identical suction probe measured the initial number of inhaled particles at the nostril. The two suction probes were connected to two identical laser particle counters and allowed calculation of particle deposition. Particles 1–3 μm in size were deposited to about 60% within the entire nasal cavity, whereas most of the particles 4–30 μm in size were deposited within the entire nasal cavity. Between 80% and 90% of the particles retained in the nasal cavity were deposited at the anterior nasal segment. Studies on deposition of various drugs within the nasal cavity using this experimental set-up are conceivable.

Video-endoscopy and digital image analysis of the nasal valve area

The aim of this study was to evaluate the benefit of digital image analysis of video-endoscopic images of the valve area to study changes in cross-sections of the nasal valve area before and after nasal surgery. Fifty patients scheduled for septoplasty or septorhinoplasty were included. Successful recordings of the valve area and digitally calculated cross-sections of the nasal valve area served as main outcome measures. First, various endoscopes (rigid 0°- and 25°-endoscopes and fibreoptic 0°-endoscope) were tested and video-endoscopy was standardised in 39 patients. Second, preoperative and postoperative images of the nasal valve area in 11 patients with obstruction of the nasal valve area were digitally analysed and compared. In these patients, a significant widening of the valve area could be shown postoperatively. We conclude that digital image analysis of the nasal valve area can be helpful in the measurement of cross-sections of the nasal valve area before and after nasal surgical procedures in selected patients.

Nasal air conditioning in relation to acoustic rhinometry values

Background Changes of nasal dimensions can influence the air-conditioning capacity of the nose because of alterations of airflow patterns. The goal of this study was to evaluate the correlation between intranasal temperature and humidity values and nasal dimensions, assessed by means of acoustic rhinometry. Methods Eighty healthy volunteers (40 men and 40 women; median age, 51 years; range, 20–84 years) were enrolled in the study. In total, 160 nasal cavities were examined. All volunteers underwent a standardized acoustic rhinometry. Additionally, intranasal air temperature and humidity measurements at defined intranasal detection sites within the anterior nasal segment were performed. Results There was no statistically significant difference between the right and left side of the nose regarding air temperature, absolute humidity, and acoustic rhinometric values. A negative correlation was established between the rhinometric nasal volumes/minimal cross-sectional areas and air temperature and absolute humidity values at the three intranasal detection sites. Conclusion According to our results, nasal volumes and cross- sectional areas relevantly influence nasal air conditioning. A healthy nasal cavity with smaller volumes and cross-sectional areas seems to present a more effective air-conditioning function than a too “wide” open nose because of changes in airflow patterns. This observation should be considered as a limitation for overly extensive nasal surgery especially of the turbinates.