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Dive into the research topics where Richard Longnecker is active.

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Featured researches published by Richard Longnecker.


Cell | 1991

Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death

S Henderson; Martin Rowe; Christopher D. Gregory; Debbie Croom-Carter; Fred Wang; Richard Longnecker; Elliott Kieff; Alan B. Rickinson

Epstein-Barr virus (EBV) not only induces growth transformation in human B lymphocytes, but has more recently been shown to enhance B cell survival under suboptimal conditions where growth is inhibited; both effects are mediated through the coordinate action of eight virus-coded latent proteins. The effect upon cell survival is best recognized in EBV-positive Burkitts lymphoma cell lines where activation of full virus latent gene expression protects the cells from programmed cell death (apoptosis). Here we show by DNA transfection into human B cells that protection from apoptosis is conferred through expression of a single EBV latent protein, the latent membrane protein LMP 1. Furthermore, we demonstrate that LMP 1 mediates this effect by up-regulating expression of the cellular oncogene bcl-2. The interplay between EBV infection and expression of this cellular oncogene has important implications for virus persistence and for the pathogenesis of virus-associated malignant disease.


Proceedings of the National Academy of Sciences of the United States of America | 1994

An integral membrane protein (LMP2) blocks reactivation of Epstein-Barr virus from latency following surface immunoglobulin crosslinking.

Cheryl L. Miller; Jennifer H. Lee; Elliott Kieff; Richard Longnecker


Journal of Virology | 1993

Epstein-Barr virus latent membrane protein 2A blocks calcium mobilization in B lymphocytes.

Cheryl L. Miller; Richard Longnecker; Elliott Kieff


Journal of Virology | 1991

An Epstein-Barr virus protein associated with cell growth transformation interacts with a tyrosine kinase.

Richard Longnecker; Brian J. Druker; Thomas M. Roberts; Elliott Kieff


Journal of Virology | 1990

A second Epstein-Barr virus membrane protein (LMP2) is expressed in latent infection and colocalizes with LMP1.

Richard Longnecker; Elliott Kieff


Journal of Virology | 1992

An Epstein-Barr virus transformation-associated membrane protein interacts with src family tyrosine kinases.

Burkhardt Al; J B Bolen; Elliott Kieff; Richard Longnecker


Journal of Virology | 1993

The last seven transmembrane and carboxy-terminal cytoplasmic domains of Epstein-Barr virus latent membrane protein 2 (LMP2) are dispensable for lymphocyte infection and growth transformation in vitro.

Richard Longnecker; Cheryl L. Miller; X-Qian Miao; B Tomkinson; Elliott Kieff


Journal of Virology | 1992

The only domain which distinguishes Epstein-Barr virus latent membrane protein 2A (LMP2A) from LMP2B is dispensable for lymphocyte infection and growth transformation in vitro; LMP2A is therefore nonessential.

Richard Longnecker; C. L. Miller; X-Qian Miao; Andrew Marchini; Elliott Kieff


Journal of Virology | 1993

Deletion of DNA encoding the first five transmembrane domains of Epstein-Barr virus latent membrane proteins 2A and 2B.

Richard Longnecker; Cheryl L. Miller; B Tomkinson; X-Qian Miao; Elliott Kieff


Infectious agents and disease | 1994

Epstein-Barr virus protein LMP2A regulates reactivation from latency by negatively regulating tyrosine kinases involved in sIg-mediated signal transduction.

Cheryl L. Miller; Jennifer H. Lee; Elliott Kieff; Burkhardt Al; J B Bolen; Richard Longnecker

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