Richard Longnecker
Harvard University
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Publication
Featured researches published by Richard Longnecker.
Cell | 1991
S Henderson; Martin Rowe; Christopher D. Gregory; Debbie Croom-Carter; Fred Wang; Richard Longnecker; Elliott Kieff; Alan B. Rickinson
Epstein-Barr virus (EBV) not only induces growth transformation in human B lymphocytes, but has more recently been shown to enhance B cell survival under suboptimal conditions where growth is inhibited; both effects are mediated through the coordinate action of eight virus-coded latent proteins. The effect upon cell survival is best recognized in EBV-positive Burkitts lymphoma cell lines where activation of full virus latent gene expression protects the cells from programmed cell death (apoptosis). Here we show by DNA transfection into human B cells that protection from apoptosis is conferred through expression of a single EBV latent protein, the latent membrane protein LMP 1. Furthermore, we demonstrate that LMP 1 mediates this effect by up-regulating expression of the cellular oncogene bcl-2. The interplay between EBV infection and expression of this cellular oncogene has important implications for virus persistence and for the pathogenesis of virus-associated malignant disease.
Proceedings of the National Academy of Sciences of the United States of America | 1994
Cheryl L. Miller; Jennifer H. Lee; Elliott Kieff; Richard Longnecker
Journal of Virology | 1993
Cheryl L. Miller; Richard Longnecker; Elliott Kieff
Journal of Virology | 1991
Richard Longnecker; Brian J. Druker; Thomas M. Roberts; Elliott Kieff
Journal of Virology | 1990
Richard Longnecker; Elliott Kieff
Journal of Virology | 1992
Burkhardt Al; J B Bolen; Elliott Kieff; Richard Longnecker
Journal of Virology | 1993
Richard Longnecker; Cheryl L. Miller; X-Qian Miao; B Tomkinson; Elliott Kieff
Journal of Virology | 1992
Richard Longnecker; C. L. Miller; X-Qian Miao; Andrew Marchini; Elliott Kieff
Journal of Virology | 1993
Richard Longnecker; Cheryl L. Miller; B Tomkinson; X-Qian Miao; Elliott Kieff
Infectious agents and disease | 1994
Cheryl L. Miller; Jennifer H. Lee; Elliott Kieff; Burkhardt Al; J B Bolen; Richard Longnecker