Is this you? Create Your Porfile
Avatar

Richard N. Booher

Eli Lilly and Company

Network

Latest external collaboration on country level. Dive into details by clicking on the dots.

Explore More

Hotspot

Dive into the research topics where Richard N. Booher is active.

Explore More

Publication

Featured researches published by Richard N. Booher.

Life Sciences | 1974

α-1-Acetylmethadol and its N-demethylated metabolites have potent opiate action in the guinea pig isolated ileum

Rodney Nickander; Richard N. Booher; Henry Miles

Abstract α-1-Acetylmethadol (LAM) and its N-demethylated metabolites α-1-noracetylmethadol (NAM) and α-1- dinoracetylmethadol (NNAM) exhibited opiate-like actions in vitro by depressing the electrically induced twitch of the longitudinal muscle of the guinea pig ileum. These effects were reversed by the opiate antagonist naloxone. The effect of both NAM and NNAM was approximately 15 times greater than LAM. The 50 percent inhibitory concentrations of the metabolites were well below those levels in plasma reported for man. The long duration of action of LAM as an opiate substitute is most likely due to the conversion to its metabolites.

Journal of Medicinal Chemistry | 1973

Metabolism of acetylmethadol. A sensitive assay for noracetylmethadol and the identification of a new active metabolite.

Ruth E. Billings; Richard N. Booher; Stephen E. Smits; Albert Pohland; Robert E. McMahon

Journal of Organic Chemistry | 1997

Application of Palladium(0)-Catalyzed Processes to the Synthesis of Oxazole-Containing Partial Ergot Alkaloids

Benjamin Alan Anderson; Lisa M. Becke; Richard N. Booher; Michael Edward Flaugh; Nancy Kay Harn; Thomas J. Kress; David L. Varie; James P. Wepsiec

Archive | 1995

6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenz[cd]indoles

Richard N. Booher; David Ernest Lawhorn; Michael J. Martinelli; Charles J. Paget; John Mehnert Schaus

Archive | 1995

6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD] indoles

Richard N. Booher; David Ernest Lawhorn; Charles J. Paget; John Mehnert Schaus

Journal of Medicinal Chemistry | 1987

Synthesis of D-oxa tricyclic partial ergolines as dopamine agonists

Richard N. Booher; Edmund C. Kornfeld; E. Barry Smalstig; James A. Clemens

Journal of Medicinal Chemistry | 1977

Various 5-substituted and 2,5-disubstituted 1,3-dioxanes, a new class of analgesic agents.

Richard N. Booher; Stephen E. Smits; William W. Turner; Albert Pohland

Journal of Medicinal Chemistry | 1975

Synthesis of a new metabolite of acetylmethadol.

Richard N. Booher; Albert Pohland

Journal of Medicinal Chemistry | 1977

Synthesis of two metabolites of (+)-propoxyphene

William W. Turner; Richard N. Booher; Stephen E. Smits; Albert Pohland

Archive | 1991

6-HETEROCYCLIC-4-AMINO-1,2,2A,3,4,5-HEXAHYDROBENZ(CD)INDOLES AND PHARMACEUTICAL USE THEREOF

Richard N. Booher; David Ernest Lawhorn; Michael J. Martinelli; Charles J. Paget; John Mehnert Schaus

Explore More

Collaboration

Dive into the Richard N. Booher's collaboration.

Top Co-Authors
Avatar

John Mehnert Schaus

Eli Lilly and Company

View shared research outputs
Top Co-Authors
Avatar

Albert Pohland

Eli Lilly and Company

View shared research outputs
Top Co-Authors
Avatar

Charles J. Paget

Eli Lilly and Company

View shared research outputs
Top Co-Authors
Avatar

David Ernest Lawhorn

Eli Lilly and Company

View shared research outputs
Top Co-Authors
Avatar

Edmund C. Kornfeld

Eli Lilly and Company

View shared research outputs
Top Co-Authors
Avatar

Diane Lynn Huser

Eli Lilly and Company

View shared research outputs
Top Co-Authors
Avatar

Michael J. Martinelli

Eli Lilly and Company

View shared research outputs
Top Co-Authors
Avatar

Michael Edward Flaugh

Eli Lilly and Company

View shared research outputs
Top Co-Authors
Avatar

Cynthia L. Nichols

Eli Lilly and Company

View shared research outputs
Top Co-Authors
Avatar

David T. Wong

Eli Lilly and Company

View shared research outputs
Explore More
Researchain Logo
Decentralizing Knowledge