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Featured researches published by Richard P. Kitson.


Brain Research Reviews | 1997

The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions.

Bruce S. McEwen; Christine A. Biron; Kenneth W. Brunson; Karen Bulloch; William H. Chambers; Firdaus S. Dhabhar; Ronald H. Goldfarb; Richard P. Kitson; Andrew H. Miller; Robert L. Spencer; Jay M. Weiss

Bruce S. McEwen , Christine A. Biron , Kenneth W. Brunson , Karen Bulloch , William H. Chambers , Firdaus S. Dhabhar , Ronald H. Goldfarb , Richard P. Kitson , Andrew H. Miller , Robert L. Spencer , Jay M. Weiss d a Laboratory of Neuroendocrinology, Rockefeller UniÕersity, 1230 York AÕenue, Box 165, New York, NY 10021, USA b DiÕision of Biology and Medicine, Brown UniÕersity, ProÕidence, RI, USA c Pittsburgh Cancer Institute, UniÕersity of Pittsburgh, School of Medicine, Pittsburgh, PA, USA d Department of Psychiatry and BehaÕioral Sciences, Emory UniÕersity School of Medicine, Atlanta, GA, USA


International Journal of Oncology | 2011

A KDR-binding peptide (ST100,059) can block angiogenesis, melanoma tumor growth and metastasis in vitro and in vivo

Luca Rastelli; Maria Luisa Valentino; Melissa Corso Minderman; Judith Landin; Uriel M. Malyankar; Mary Kay Lescoe; Richard P. Kitson; Kenneth W. Brunson; Lina Souan; Salvatore Forenza; Ronald H. Goldfarb; Shafaat A. Rabbani

A major goal of treatment strategies for cancer is the development of agents which can block primary tumor growth and development as well as the progression of tumor metastasis without any treatment associated side effects. Using mini peptide display (MPD) technology, we generated peptides that can bind to the human vascular endothelial growth factor (VEGF) receptor KDR. These peptides were evaluated for their ability to block angiogenesis, tumor growth and metastasis in vitro and in vivo. A D-amino acid peptide with high serum stability (ST100,059) was found to have the most potent activity in vitro as indicated by inhibition of VEGF stimulation of endothelial cells. It was also found to be the most active of the series in blocking VEGF-mediated activity in vivo, as measured in Matrigel-filled angioreactors implanted in mice. ST100,059 blocks VEGF-induced MAPK phosphorylation, as well as inhibits VEGF-induced changes in gene expression in HUVEC cells. In in vivo studies, treatment of female C57BL/6 mice inoculated with B16 mouse melanoma cells with ST100,059 resulted in a dose-dependent decrease in tumor volume and lung metastasis as compared to control groups of animals receiving vehicle alone. These studies demonstrate that by using MPD, peptides can be identified with enhanced affinity relative to those discovered using phage display. Based on these studies we have identified one such peptide ST100,059 which can effectively block tumor growth and metastasis due to its anti-angiogenic effects and ability to block intracellular signaling pathways involved in tumor progression.


Hepatology | 1995

Immediate early detection of urokinase receptor after partial hepatectomy and its implications for initiation of liver regeneration

Wendy M. Mars; Meng-Lun Liu; Richard P. Kitson; Ronald H. Goldfarb; Megan K. Gabauer; George K. Michalopoulos


Archive | 2005

Anti-Angiogenic Peptides and Methods of Use Thereof

Luca Rastelli; Mary Kay Lescoe; Melissa Corso; Richard P. Kitson; Judith Landin; Lina Souan; Uriel M. Malyankar


Cancer Research | 1999

Evidence for Involvement of B Lymphocytes in the Surveillance of Lung Metastasis in the Rat

Ning Quan; Zhaobin Zhang; Melissa K. Demetrikopoulos; Richard P. Kitson; William H. Chambers; Ronald H. Goldfarb; Jay M. Weiss


Journal of Immunology | 1998

Matrix Metalloproteinases Produced by Rat IL-2-Activated NK Cells

Richard P. Kitson; Pierette M. Appasamy; Ulf Nannmark; Per Albertsson; Megan K. Gabauer; Ronald H. Goldfarb


Journal of Immunology | 1992

Nongranular proteolytic enzymes of rat IL-2-activated natural killer cells. I. Subcellular localization and functional role.

Ronald H. Goldfarb; K Wasserman; Ronald B. Herberman; Richard P. Kitson


Anticancer Research | 2001

Expression of neutrophil collagenase (MMP-8) in Jurkat T leukemia cells and its role in invasion.

Myoung H. Kim; Per Albertsson; Yaming Xue; Ulf Nannmark; Richard P. Kitson; Ronald H. Goldfarb


Anticancer Research | 1999

Enhanced anti-metastatic efficacy of IL-2 activated NK (A-NK) cells with novel benzothiazoles.

Ronald H. Goldfarb; Richard P. Kitson; Brunson Kw; Yoshino K; Hirota N; Kirii Y; Kotera Y; Inoue Y; Ohashi M


Journal of Cellular Biochemistry | 1994

Nongranular proteolytic enzymes of rat IL‐2–activated natural killer cells. II. Purification and identification of rat A‐NKP 1 and A‐NKP 2 as constituents of the multicatalytic proteinase (proteasome) complex

Ken Wasserman; Richard P. Kitson; Megan K. Gabauer; Ronald B. Herberman; Simon C. Watkins; Ronald H. Goldfarb; A. Jennifer Rivett; Sean T. Sweeney

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Ronald H. Goldfarb

University of North Texas Health Science Center

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Ken Wasserman

University of Pittsburgh

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Per H. Basse

University of Pittsburgh

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Per Albertsson

Sahlgrenska University Hospital

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Ulf Nannmark

University of Gothenburg

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