Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Rie Ueki is active.

Publication


Featured researches published by Rie Ueki.


Archives of Dermatological Research | 1992

Immunohistochemical localization of basic fibroblast growth factor in wound healing sites of mouse skin

Yoriyuki Kurita; Ryoji Tsuboi; Rie Ueki; Daniel B. Rifkin; Hideoki Ogawa

SummaryThe immunohistochemical localization of basic fibroblast growth factor (bFGF) was examined during wound healing in mouse skin. Frozen sections taken from the rounded skin defects were reacted with polyclonal anti-human recombinant bFGF IgG followed by incubation with FITC-conjugated IgG. The basal layer keratinocytes and hair bulbs at the wound edge were strongly stained with this antibody. In the reepithelized area, several layers of keratinocytes from the basal layer were positively stained regardless of the time after wounding. These findings suggest that germinative keratinocytes which express bFGF function as leading cells in the covering of the wound defect. However, dermal granulation tissue, including capillary endothelial cells, fibroblasts and macrophages unexpectedly did not demonstrate any immunoreactivity throughout the process of wound healing. Simultaneous histochemical investigation using cultivated mouse keratinocytes and bovine aortic endothelial cells showed primarily cytoplasmic fluorescence. The discrepancy in the staining patterns of endothelial cells in vivo and in vitro suggests that immunoreactive bFGF is either not expressed in vivo, or is processed or masked.


Journal of Dermatological Science | 2009

Oral administration of Yokukansan inhibits the development of atopic dermatitis-like lesions in isolated NC/Nga mice

Ju Jiang; Takuji Yamaguchi; Naoko Funakushi; Takatoshi Kuhara; Ping-shen Fan; Rie Ueki; Hajime Suto; Yoshio Kase; Shigaku Ikeda; Hideoki Ogawa

BACKGROUND Increasing evidence suggests that stress can trigger and exacerbate atopic dermatitis (AD). Psychotherapy is becoming more important in the treatment of AD patients. Yokukansan (YKS, Yi-Gan San in Chinese), a traditional Japanese medicine, has been widely utilized in the treatment of neurosis, insomnia and anxiety especially in Asian countries. Furthermore, it was reported that YKS inhibited skin lesions in socially isolated mice but not in group-housed mice. Therefore, in the present study it was investigated whether or not YKS was effective in the treatment of AD using socially isolated NC/Nga mice. OBJECTIVE The present study was designed to assess the effect of YKS on the development of AD-like lesions in socially isolated NC/Nga mice to obtain information about its usefulness in the treatment of AD. METHODS Ten-week-old male NC/Nga mice were socially isolated under conventional conditions. YKS was administered orally to mice at the dose of 0.5% or 1.0% together with diet. The efficacy of YKS was evaluated by assessing skin lesion severity, scratching behaviors, skin hydration, and infiltration of inflammatory cells in the skin. Grooming behaviors evoked by social isolation stress and serum corticosterone levels were also measured. RESULTS Oral administration of YKS to socially isolated NC/Nga mice resulted in the inhibition of exacerbation of AD-like skin lesions. It seemed that the inhibition of exacerbation of AD-like skin lesions observed in NC/Nga mice might be due to suppression of the scratching and grooming behaviors, inhibition of the infiltration of mast cells and eosinophils, and retention of humidity in the skin. Serum corticosterone levels were also significantly inhibited in the 1%-YKS-treated mice as compared with those of the control mice. There were no significant differences in the levels of serum total IgE and nerve growth factor (NGF) between the YKS-treated mice and the non-treated control mice. CONCLUSION YKS inhibited the development of AD-like skin lesions in socially isolated NC/Nga mice by suppressing scratching and infiltration of inflammatory cells in the skin. These results indicate that YKS possesses an anti-itching property, and its anti-itching may be partly through attenuation on social isolation stress. It is expected that YKS might provide an effective alternative therapy for AD in human patients.


Journal of Dermatology | 2012

Guidelines for the management of androgenetic alopecia (2010)

Ryoji Tsuboi; Satoshi Itami; Shigeki Inui; Rie Ueki; Kensei Katsuoka; Sotaro Kurata; Takeshi Kono; Norimitsu Saito; Motomu Manabe; Masashi Yamazaki

Guidelines for the management of androgenetic alopecia (2010) Ryoji TSUBOI, Satoshi ITAMI, Shigeki INUI, Rie UEKI, Kensei KATSUOKA, Sotaro KURATA, Takeshi KONO, Norimitsu SAITO, Motomu MANABE, Masashi YAMAZAKI, GUIDELINES PLANNING COMMITTEE FOR THE MANAGEMENT OF ANDROGENETIC ALOPECIA Department of Dermatology, Tokyo Medical University, Tokyo, Department of Regenerative Dermatology, Osaka University Graduate School of Medicine, Osaka, Department of Dermatology, Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Department of Dermatology, School of Medicine, Kitasato University, Sagamihara, Kurata Clinic, Beppu, Department of Dermatology, Nippon Medical School, Tokyo, and Department of Dermatology, Akita University Graduate School of Medicine, Akita, Japan


Dermatology | 2003

Recurrent E413K Mutation of hHb6 in a Japanese Family with Monilethrix

Shigenori Muramatsu; Tami Kimura; Rie Ueki; Ryoji Tsuboi; Shigaku Ikeda; Hideoki Ogawa

Monilethrix is an autosomal dominant hair disorder characterized by a beaded appearance of the hair due to periodic thinning of the shaft. This disorder has been reported to be caused by mutations in the helix termination motif of two type II cortex keratins, hHb1 and hHb6. Here we describe a Japanese monilethrix family that has the most frequent mutation, the E413K mutation in hHb6, so far found in 26 families. Genotype/phenotype correlation was not obvious in our case or in the previously reported cases.


BioMed Research International | 2014

Yokukansan, a traditional Japanese medicine, adjusts glutamate signaling in cultured keratinocytes.

Maki Wakabayashi; Toshio Hasegawa; Takuji Yamaguchi; Naoko Funakushi; Hajime Suto; Rie Ueki; Hiroyuki Kobayashi; Hideoki Ogawa; Shigaku Ikeda

Glutamate plays an important role in skin barrier signaling. In our previous study, Yokukansan (YKS) affected glutamate receptors in NC/Nga mice and was ameliorated in atopic dermatitis lesions. The aim of this study was to assess the effect of YKS on skin and cultured human keratinocytes. Glutamate concentrations in skin of YKS-treated and nontreated NC/Nga mice were measured. Then, glutamate release from cultured keratinocytes was measured, and extracellular glutamate concentrations in YKS-stimulated cultured human keratinocytes were determined. The mRNA expression levels of NMDA receptor 2D (NMDAR2D) and glutamate aspartate transporter (GLAST) were also determined in YKS-stimulated cultured keratinocytes. The glutamate concentrations and dermatitis scores increased in conventional mice, whereas they decreased in YKS-treated mice. Glutamate concentrations in cell supernatants of cultured keratinocytes increased proportionally to the cell density. However, they decreased dose-dependently with YKS. YKS stimulation increased NMDAR2D in a concentration-dependent manner. Conversely, GLAST decreased in response to YKS. Our findings indicate that YKS affects peripheral glutamate signaling in keratinocytes. Glutamine is essential as a transmitter, and dermatitis lesions might produce and release excess glutamate. This study suggests that, in keratinocytes, YKS controls extracellular glutamate concentrations, suppresses N-methyl-D-aspartate (NMDA) receptors, and activates glutamate transport.


Journal of Dermatology | 2018

Guidelines for the diagnosis and treatment of male‐pattern and female‐pattern hair loss, 2017 version

Motomu Manabe; Ryoji Tsuboi; Satoshi Itami; Shin-Ichi Osada; Yasuyuki Amoh; Taisuke Ito; Shigeki Inui; Rie Ueki; Manabu Ohyama; Sotaro Kurata; Takeshi Kono; Norimitsu Saito; Akio Sato; Yutaka Shimomura; Motonobu Nakamura; Hiroshi Narusawa; Masashi Yamazaki

Male‐pattern hair loss (MPHL, androgenetic alopecia) is a slowly progressive form of alopecia which begins after puberty. In 2010, we published the first Japanese edition of guidelines for the diagnosis and treatment of MPHL. It achieved the original goal of providing physicians and patients in Japan with evidence‐based information for choosing efficacious and safe therapy for MPHL. Subsequently, new therapeutic drugs and treatment methods have been developed, and womens perception of MPHL has undergone change and the term “female‐pattern hair loss (FPHL)” is becoming more common internationally. Thus, here we report a revised version of the 2010 guidelines aimed at both MPHL and FPHL. In these guidelines, finasteride 1 mg daily, dutasteride 0.5 mg daily and topical 5% minoxidil twice daily for MPHL, and topical 1% minoxidil twice daily for FPHL, are recommended as the first‐line treatments. Self‐hair transplantation, irradiation by light‐emitting diodes and low‐level lasers, and topical application of adenosine for MPHL are recommended, whereas prosthetic hair transplantation and oral administration of minoxidil should not be performed. Oral administration of finasteride or dutasteride are contraindicated for FPHL. In addition, we have evaluated the effectiveness of topical application of carpronium chloride, t‐flavanone, cytopurine, pentadecane and ketoconazole, and wearing a wig. Unapproved topical application of bimatoprost and latanoprost, and emerging hair regeneration treatments have also been addressed. We believe that the revised guidelines will improve further the diagnostic and treatment standards for MPHL add FPHL in Japan.


Journal of Dermatological Science | 2009

Erratum to “Oral administration of Yokukansan inhibits the development of atopic dermatitis-like lesions in isolated NC/Nga mice” [J. Dermatol. Sci. 56 (2009) 37–42]

Ju Jiang; Takuji Yamaguchi; Naoko Funakushi; Takatoshi Kuhara; Ping-shen Fan; Rie Ueki; Hajime Suto; Yoshio Kase; Shigaku Ikeda; Hideoki Ogawa

Erratum to ‘‘Oral administration of Yokukansan inhibits the development of atopic dermatitis-like lesions in isolated NC/Nga mice’’ [J. Dermatol. Sci. 56 (2009) 37–42] Ju Jiang *, Takuji Yamaguchi , Naoko Funakushi , Takatoshi Kuhara , Ping-shen Fan , Rie Ueki , Hajime Suto , Yoshio Kase , Shigaku Ikeda , Hideoki Ogawa a,b Atopy (Allergy) Research Center, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421 Tokyo, Japan Department of Dermatology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421 Tokyo, Japan Dermatology Unit, Juntendo Tokyo Geriatric Medical Center, 3-3-20 Shinsuna, Koto-ku, 136-0075 Tokyo, Japan d Tsumura Research Laboratories, Tsumura & Co, 3586 Yoshiwara, Ami-machi, Inashiki-gun, 300-1192 Ibaraki, Japan e Fuzhou Dermatosis Prevention and Control Hospital, 243 Xi Hong Lu, Gu Lou Qu, 350025 FuZhou, China


European Journal of Dermatology | 2004

Finasteride in the treatment of Japanese men with male pattern hair loss

Makoto Kawashima; Nobukazu Hayashi; Atsuyuki Igarashi; Hirohito Kitahara; Mizue Maeguchi; Atsuko Mizuno; Yasuko Murata; Toshitatsu Nogita; Kiyoshi Toda; Ryoji Tsuboi; Rie Ueki; Mina Yamada; Masashi Yamazaki; Takuma Matsuda; Yutaka Natsumeda; Kihito Takahashi; Shotaro Harada


European Journal of Dermatology | 2007

A randomized, placebo-controlled trial of 1% topical minoxidil solution in the treatment of androgenetic alopecia in Japanese women.

Ryoji Tsuboi; Takao Tanaka; Tooru Nishikawa; Rie Ueki; Hidekazu Yamada; Kensei Katsuoka; Hideoki Ogawa; Katsuyuki Takeda


Archives of Dermatological Research | 2011

Ameliorating effect of Yokukansan on the development of atopic dermatitis-like lesions and scratching behavior in socially isolated NC/Nga mice

Naoko Funakushi; Takuji Yamaguchi; Ju Jiang; Sachiko Imamura; Takatoshi Kuhara; Hajime Suto; Rie Ueki; Yoshio Kase; Hiroyuki Kobayashi; Hideoki Ogawa; Shigaku Ikeda

Collaboration


Dive into the Rie Ueki's collaboration.

Top Co-Authors

Avatar
Top Co-Authors

Avatar

Ryoji Tsuboi

Tokyo Medical University

View shared research outputs
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Top Co-Authors

Avatar
Researchain Logo
Decentralizing Knowledge