Rima Irwinda

Maternal and cord blood cyclophilin A in severe preeclampsia and normal pregnancy and its correlation with vitamin D and zinc

ABSTRACT Objective: To investigate maternal and cord blood cyclophilin A level in severe preeclampsia compared with normal pregnancy and its correlation with vitamin D and zinc level. Methods: We conducted a cross-sectional observational study of pregnant women who gave birth in Cipto Mangunkusumo Hospital between January and April 2014. Results: Thirty-nine subjects were included. Subjects with severe preeclampsia have higher serum cyclophilin A levels compared with normotensive pregnancy (1299.60 vs. 1039.50; p 0.017). Maternal cyclophilin A, vitamin D, and zinc correlation were not statistically significant (p 0.189 & p 0.853). Conclusion: Cyclophilin A levels in severe preeclampsia is higher compared to normal pregnancy. There is no correlation between cyclophilin A, zinc, and vitamin D.

Delivery Outcome Among Pregnant Women With Hypertension

Background: Hypertension in pregnancy remains a major cause of maternal and perinatal morbidity and mortality worldwide. The purpose of this study was to compare maternal and neonatal outcomes among women with hypertension (chronic hypertension (CHT), superimposed preeclamsia (SuperPE), gestational hypertension (GHT), mild preeclamsia (MPE), severe preeclamsia (SeverePE),and HELLP syndrome (HELLPs)). Methods: This retrospective evaluation was performed during January to December 2013 at Cipto Mangunkusumo Hospital, Jakarta-Indonesia, a tertiary-care hospital. The data was obtained from singleton deliveries database including women with hypertension(CHT, SuperPE, GHT, MPE, SeverePE,HELLPs) and control group (normotension and without comorbidities). Univariate and multivariate logistic regression analysis were performed. Results: There were 2103 deliveries in RSCM, 510 (24.3%) had hypertension in pregnancy and 1593 (75.7%) were control subject. CHT, SuperPE, GHT, MPE, severePE, HELLPs, were respectively found in 0.3%, 0.8%, 2.9%, 2.1%, 16.3%, and 1.8% in our patients. After adjusting with age, parity and comorbidities, the risk of having premature neonates are increased in women with HELLPs (adjustedOR 7.72; 95% Confidence interval (CI) 2.75–21.70), and superPE (aOR 4.41; 95% CI 1.23–15.89). Low birth weight (LBW) are increased in women with SeverePE (aOR 1.69; 95% CI 1.05–2.72) and HELLPs (aOR 24.62; 95% CI 3.33–182.16). Risk of Apgar score 5th minute below 7 is highest in women with HELLPs (aOR 9.19; 95% CI 1.58–53.57). Conclusion: Women with HELLPshad highest risks for premature neonates, LBW and Apgar score 5th minute below 7 among other types of hypertension.