Rita Derua
University of Utah
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Publication
Featured researches published by Rita Derua.
Molecular and Cellular Biology | 1994
A Cegielska; S Shaffer; Rita Derua; Jozef Goris; David M. Virshup
The ability of simian virus 40 (SV40) large T antigen to catalyze the initiation of viral DNA replication is regulated by its phosphorylation state. Previous studies have identified the free catalytic subunit of protein phosphatase 2A (PP2Ac) as the cellular phosphatase which can remove inhibitory phosphoryl groups from serines 120 and 123. The catalytic C subunit exists in the cell complexed with a 65-kDa A subunit and one of several B subunits. To determine if any of the holoenzymes could activate T antigen, we tested the ability of the heterodimeric AC and two heterotrimeric ABC forms to stimulate T-antigen function in unwinding the origin of SV40 DNA replication. Only free catalytic subunit C and the heterotrimeric form with a 72-kDa B subunit (PP2A-T72) could stimulate T-antigen-dependent origin unwinding. Both the dimeric form (PP2A-D) and the heterotrimer with a 55-kDa B subunit (PP2A-T55) actively inhibited T-antigen function. We found that PP2A-T72 activated T antigen by dephosphorylating serines 120 and 123, while PP2A-D and PP2A-T55 inactivated T antigen by dephosphorylating the p34cdc2 target site, threonine 124. Thus, alterations in the subunit composition of PP2A holoenzymes have significant functional consequences for the initiation of in vitro SV40 DNA replication. The regulatory B subunits of PP2A may play a role in regulating SV40 DNA replication in infected cells as well.
Archive | 2016
Dorien Haesen; Layka Abbasi Asbagh; Rita Derua; Antoine Hubert; Stefanie Schrauwen; Yana Hoorne; Frédéric Amant; Etienne Waelkens; Anna Sablina; Veerle Janssens
Archive | 2016
Kerstin Schott; Rita Derua; Janna Seifried; Andreas Reuter; Esther Schnellbächer; Heike Schmitz; Christiane Tondera; Nicole Esly; Felipe Diaz-Griffero; Veerle Janssens; Renate König
Archive | 2016
Mathias Cobbaut; Rita Derua; Etienne Waelkens; Peter Storz; Benjamin E. Turk; Sandy Vandoninck; Veerle Janssens; Johan Van Lint
Archive | 2016
Johan Van Lint; Rita Derua; Lina Saadah; Etienne Waelkens; Veerle Janssens; Mathias Cobbaut
Archive | 2016
Kerstin Schott; Rita Derua; Janna Seifried; Andreas Reuter; Heike Schmitz; Christiane Tondera; Alberto Brandariz-Nuñez; Felipe Diaz-Griffero; Veerle Janssens; Renate König
Archive | 2016
Mathias Cobbaut; Rita Derua; Etienne Waelkens; Peter Storz; Benjamin E. Turk; Sandy Vandoninck; Veerle Janssens; Johan Van Lint
Archive | 2015
Dorien Haesen; Layka Abbasi Asbagh; Antoine Hubert; Rita Derua; Stefanie Schrauwen; Yana Hoorne; Frédéric Amant; Etienne Waelkens; Anna Sablina; Veerle Janssens
Archive | 2014
Jelle Machiels; Evelien Rysman; Eyra Marien; Muralidhararao Bagadi; Rita Derua; Etienne Waelkens; Johan Swinnen
Archive | 2014
Eyra Marien; Michael Meister; Thomas Muley; Teresa Gómez del Pulgar; Juan Carlos Lacal; Jelle Machiels; Mercedes Binda; Paul P Van Veldhoven; Hu Yinling; Rita Derua; Etienne Waelkens; Johan Swinnen