Rita Evalina

Body mass index, atopy, and allergic diseases

Background Prevalence of atopy, allergic diseases, and obesity are increasing. Atopy is an individu and/or familial tendency to sensitization in response to ordinary exposure to allergens. Studies on association of BM I with atopy and allergic diseases in children were limited, with inconclusive results. Objective To assess associations of BM I with atopy and allergic diseases in chidren. Methods A cross-sectional was conducted in school children aged 6-12 years in Lhokseumawe City, Aceh, June 2012. Children were assessed for BMI, skin prick test, and International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Statistical analyses included Chi-square, Fisher exact, and logistic regression. Results The subjects consisted of 137 (85.6%) normoweight, 12 (7.5%) overweight, and 11 (6.9%) obesity. Skin prick test results were positive in 44 (27.5%) and negative in 116 (72.5%) subjects. Allergic manifestations were allergic rhinitis (AR) 17 (10.6%), bronchial asthma 6 (3.8%), and atopic dermatitis (AD) 3 (1.9%). There was significant association of obesity with atopy, compared with normoweight (OR=3.78; 95%CI 1.08 to 13.19; P=0.037), but no significant association found when family history of atopy also assesed. There was significant association of obesity with bronchial asthma (OR=9.92; 95%CI 1.46 to 67.18; P=0.004) and AR (OR=6.49; 95%CI 1.64 to 25.66; P=0.015), compared with normoweight children. Significant association of overweight with atopy and allergic disease were not found. Conclusion Obese children are more likely to have atopy, bronchial asthma, and allergic rhinitis, but overweight and normoweight children are not.

Total serum IgE levels in soil-transmitted helminth infected children with atopy symptoms

Background High total serum immunoglobulin E (IgE) levels and eosinophilia are markers for atopy, but other factors may also play a key role in affecting atopy, such as intestinal parasitic infection. Helminthiasis has been associated with a reduced risk of atopy and asthma symptoms in areas with high prevalence of parasitic infections. Objective To assess for associations between total serum IgE level and soil-transmitted helminthiasis (STH) infection, as well as between STH infection and allergy symptoms. Methods We conducted a cross-sectional stu dy on 84 consecutively-enrolled children , aged 7- 13 years, in the Secanggang Subdistrict, Langkat District, North Sumatera Province. Subjects were enrolled into one of two groups, with or without STH infection. Total serum IgE measurements and stool STH examinations were performed in all subjects. Data on atopy or allergy symptoms were obtained by parental interview. Results The 42 subjects with STH infection had significantly higher mean total serum lg E levels than the 42 subjects without infec tion, 1,13 1.26 IU/mL and 744.76 IU/mL, respectiv ely (P = 0.029). We also fo und significant positive association s between STH infection and asthma symptoms (P= 0.049), as well as eczema symptoms (P=0.044). Conclusion Mean total serum IgE level is higher in STHinfected subjects than in those without infection. In addition, STH infection is positively associated with asthma and eczema symptoms.