Rita Menicagli

Selective Mono- or Dialkoxylation of 2,4,6-Trichloro-1,3,5-triazine in Solid-Liquid Phase Transfer Conditions

Abstract In solid-liquid phase transfer conditions, both the primary and the secondary alcohols react cleanly with 2,4, 6-trichloro-1,3,5-triazine to give the corresponding mono or dialkoxy derivatives depending on the reagent molar ratio.

2-alkyl-4,6-dialkylamino-1,3,5-triazines via Grignard alkylation of cyanuric chloride: An aged reaction revisited

Abstract Suitable one-pot reaction conditions are suggested to prepare, in good overall yields, some 2-(alk-1′-ynyl)- and 2-alkyl-4,6-dialkylamino-1,3,5-triazines via reaction of cyanuric chloride with Grignard reagents followed by amination.

Palladium on carbon catalyzed cross-coupling between alk-1-ynes and 2-chloro-4,6-dialkoxy-1,3,5-triazines

Abstract 2-(Alk-1′-ynyl)-4,6-dialkoxy-1,3,5-triazines have been synthesized in satisfactory yields by (Pd/C)/PPh 3 /CuI catalyzed cross-coupling between alk-1-ynes and 2-chloro-4,6-dialkoxy-1,3,5-triazines carried out in the presence of diisopropylethylamine or K 2 CO 3 /18-crown-6.

1,4-Conjugate addition of the reformatsky reagent to α-nitrostyrenes: A new synthesis of γ-nitroesters.

Abstract α-Nitrostyrenes react with the Reformatsky reagent to yield the corresponding 1,4-addition products. The reaction represents a practical and convenient route to ethyl 3-aryl-4-nirobutanoates.

2-(Alk-1’-ynyl)-4,6-dimethoxy-1,3,5-triazines via Pd-mediated alkynylation of 2-chloro-4,6-dimethoxy-1,3,5-triazine

Abstract In the presence of a catalytic amount of (Ph 3 P) 4 Pd, 2-chloro-4,6-dimethoxy-1,3,5-triazine reacts with alk-1-ynes to give the corresponding 2-(alk-1′-ynyl)-derivatives in satisfactory yields. Depending on the nature of the alk-1-ynes, Pd(10%) C can also be used to catalyze the cross-coupling.

NMR Detection of the Conformational Distortion Induced in Cyclodextrins by Introduction of Alkyl or Aromatic Substituents

The conformational features of alkylated, benzoylated, and benzylated cyclodextrins in solution were analysed by NOE and proton-selective relaxation methods and were compared to those of native compounds.

Selective Amination of Cyanuric Chloride in the Presence of 18‐Crown‐6

An interpretation of the role of 18-crown-6 in the selective di- and trialkylamination of 2,4,6-trichloro-1,3,5-triazine is reported, and the usefulness of the procedure is shown. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)

2,4,6-Tri[(S)-1′-methylbenzylamino]-1,3,5-triazine: a new NMR chiral solvating agent for 3,5-dinitrophenyl derivatives; an attempt at a chiral discrimination rationale

Abstract The use of 2,4,6-tri[( S )-1′-methylbenzylamino]-1,3,5-triazine as a chiral solvating agent for the NMR evaluation of the enantiomeric excess of 3,5-dinitrophenyl derivatives is reported along with an investigation into the origin of the enantiodiscrimination process.

Chemoselective and stereospecific conjugate alkenyl group transfer to α-nitroolefins using diisobutylalkenylalanes

Abstract Diisobutylalkenylalanes, easily prepared by hydro-alumination of terminal, α-branched and internal alkynes, react with α-nitroolefins to give pure E- γ-nitroolefins in almost quantitative yields. The reaction described is a convenient and simple approach to E-β,γ-unsaturated carbonyl compounds.

Optically active α- and β- naphthalene derivatives-III1,2: Synthesis and optical purity of 2-(α- and β-naphthyl)-butanes

Abstract Optically active 2-(α- and β-naphthyl)-butanes were prepared starting from 2-(α- and β-naphthyl)-propionic acid. Their relative configurations and maximum rotatory powers were chemically established by relating them to know naphthalene derivatives and (S)-2-methyl-butan-1-ol.