Ritu Vyas

Cadmium sulfide photocatalysed reduction of malachite green by ascorbic acid and EDTA as reductants

The photoreduction of malachite green in presence of CdS as photocatalyst and ascorbic acid/EDTA as reductants has been carried out. The effect of different parameters like pH, concentration of malachite green, reductants, amount of semiconductor and light intensity on the rate of photocatalytic reaction has been studied. On the basis of observed data, a tentative mechanism for the photoreduction of malachite green has been proposed.

Microwave-Assisted Synthesis of Some 1,3,4-Oxadiazole Derivatives and Evaluation of Their Antibacterial and Antifungal Activity

A series of substituted 1,3,4-oxadiazole derivatives (3a–f) and (6a–f) have been synthesized from diphenylacetic acid hydrazide under microwave irradiation in various reaction conditions. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, and 1H NMR. These targeted compounds have been tested for their antibacterial and antifungal activities compared to ampicillin and griseofulvin as standard drug. Compounds 3a, 3e, 3f, 6c, 6d, 6e, and 6d exhibited the maximum antibacterial activities while 3b, 3c, 3d, 3e, 6a, 6d, and 6e exhibited the maximum antifungal activities.

MICROWAVE - ASSISTED SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SOME PYRAZOLE DERIVATIVES

Reaction of 3 - (1 H - indol - 3 - yl) - (1 - methyl/phenyl)prop - 2 - en - 1 - one (Chalcones) was carried out with hydrazine hydrate, phenyl hydrazine, isoniazide, nicotinic hydrazide and thiosemicarbez ide (corresp onding hydrazides) in ethanol containing a few drops of glacial acetic ac id under microwave irradiation giving 1H indol containing pyrazole derivatives. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR and 1 H NMR. All the

Microwave Assisted Synthesis of Some Pyridine Derivatives Containing Mercaptotriazole and Thiazolidinone as a New Class of Antimicrobial Agents

A fast and facile procedure for the synthesis of pyridomercaptotriazole 4a–e and pyridothiazolidinone 5a–e is being reported starting from dihydropyridine 1a–e . Subsequent oxidation with nitrating mixture (HNO 3 /H 2 SO 4 ) produced the anticipated 2,6-dimethylpyridine derivatives 2a–e , which were subsequently condensed with thiosemicarbazide in ethanol to produce the key intermediate 2,2′-[4-(4-substituted phenyl)- 2,6-dimethylpyridine-3,5-diyl]dicarbonyldihydrazine carbothioamides 3a–e . In the final step pyridomercaptotriazole derivatives 4a–e were synthesized by treating 3a–e in alkaline media. In parallel pyridothiazolidinone derivatives 5a–e were obtained by the reaction of 3a–e with ClCH 2 COOH/CH 3 COONa. All the reactions were carried out on microwave irradiation in good yield with short time. The structures of all the compounds have been confirmed on the basis of their analytical, IR, 1 H NMR, and Mass spectral data (Table I and Table II). The potent antimicrobial effects of the synthesized compounds were also investigated.

MICROWAVE-ASSISTED SYNTHESIS OF SOME BIOLOGICALLY ACTIVE PYRAZOLE DERIVATIVES

3-(4-Substituted phenyl)-5-phenyl-2,3-dihydro-1H-pyrazole (2a-c), 3-(4-substituted phenyl)-2-5-diphenyl-2,3-dihydro-1H-pyrazole (3a-c), [5-(4-substituted phenyl)-3-phenyl-2,5-dihydro-1H-pyrazole-1-yl](pyridine-4-yl)methanone (4a-c), [5-(4-substituted phenyl)-3-phenyl-2,5-dihydro-1H-pyrazole-1-yl](pyridine3-yl)methanone (5a-c) and 5-(4-substituted phenyl)-3-phenyl-2,5-dihydro-1H-pyrazole-1-carbothioamide (6a-c) have been synthesized by microwave assisted synthesis of 3-(4-Substituted phenyl)-1-phenylprop-2-en-1-ones (Chalcones) (1a-c) with hydrazine hydrate, phenyl hydrazine, isoniazide, nicotinic hydrazide or thiosemicarbezide, respectively. The synthesized compounds were characterized by IR and H NMR spectral data. Synthesized compounds have been estimated for probable activities using PASS (http://www.195.172.207.233/PASS).