Robert A. Good

Zinc nutriture in the elderly in relation to taste acuity, immune response, and wound healing

A comprehensive review is presented concerning the role of zinc (Zn) nutrition in taste acuity, immunity and wound recovery in the elderly. Specific attention is given to Zn in foods, Zn bioavailability, evidence of Zn deficiency, and the need for Zn in immune function. It was concluded that the mean daily Zn intake in groups of US elderly ranges from 7-13 mg. Dietary Zn intake appears to be related to energy intake. An apparently adequate Zn intake can be achieved for

Bone marrow transplantation—An expanding approach to treatment of many diseases

1.50-2.00/day with careful food selection; hence, people spending below

Biological amplification systems in immunology

1.50/day for food have limited ability to satisfy dietary Zn requirements. Further Zn bioavailability should be considered in the food selection process. Evidence suggests that some elderly individuals have a deficient Zn nutriture, but available data are insufficient to ascertain the frequency of this deficiency. Most instances of hypogensia in the elderly, however, are unrelated to Zn nutriture. Deficient Zn nutriture seems to contribute to poor healing in the elderly, but, again, the data are too few to ascertain frequency. Self-treatment with Zn greater than the RDA may be unwise. (wz)

PYODERMA ECZEMA AND FOLLICULITIS WITH DEFECTIVE LEUCOCYTE AND LYMPHOCYTE FUNCTION: A NEW FAMILIAL IMMUNODEFICIENCY DISEASE RESPONSIVE TO A HISTAMINE-1 ANTAGONIST

Thus, we can conclude that marrow transplantation has already influenced medical practice greatly. It has offered a treatment which often cures patients of more than 20 otherwise lethal diseases. The treatment so horrendously difficult and dangerous at first has already been greatly improved, simplified, and made much safer. The availability of a suitable donor has been much extended and real progress has been made in prevention and perhaps even in treatment of graft-versus-host disease. This has made possible the option of marrow transplantation for every patient in whom we think the treatment may be beneficial. The problem underlying many cases of interstitial pneumonia has been identified and patients are already benefitting clinically from this progress. Progress has also been made which promises antiviral therapy which could reduce, prevent, and ultimately eliminate the intercurrent virus infections which limit the applicability of marrow transplantation, especially for children with severe immunodeficiencies. I do not know how far this line of investigation can be taken. However, just as we have learned stepwise to use marrow transplants from matched siblings to treat many diseases, to use fetal liver in place of bone marrow, to employ matched relative donors when a matched sibling is not available, and, finally, even to use parental donors to achieve correction of SCID, we now have good reason to believe that, ultimately, we can use marrow transplantation without fear of GVHD to address many additional genetically determined and acquired diseases; certainly, for those diseases that involve any of the cells that are derived from bone marrow cells, and perhaps for those attributable even to cells of other organs and tissues, the functions of which are, in whole or in part, a consequence of interactions of marrow-derived cells and cells of ectodermal or endodermal origin, marrow transplantation may be useful. To us, the future of marrow transplantation as a major modality of treatment or prevention of many diseases, including hemoglobinopathesis, immunodeficiencies, hematologic abnormalities, abnormalities of function of marrow-derived cells, and even inborn errors of function of cells of organs and tissues not of marrow origin, seems bright, indeed. Further, with the capacity to introduce resistance genes against viruses and malignancies, autoimmune diseases, and diseases dependent on anomalies of immune response genes, marrow transplantation for many other diseases seems a more remote possibility.(ABSTRACT TRUNCATED AT 400 WORDS)

Influence of early or late dietary restriction on life span and immunological parameters in MRL/Mp-lpr/lpr mice.

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Infections in bone marrow transplant recipients

A new familial immunodeficiency disease characterised by recurrent and persistent pyoderma, folliculitis, and atopic dermatitis is described in a father and son. It is accompanied by abnormalities of lymphocyte function (including defective proliferative responses to phytomitogens, and subnormal response in immunoglobulin production after stimulation of the lymphocytes by pokeweed mitogen) and defective leucocyte chemiluminescence responses, which were associated with defective ability for intracellular killing of microbial organisms. The abnormalities of lymphocyte and leucocyte function, as well as the clinical manifestations, responded dramatically to treatment with the histamine-1 antagonist, chlorpheniramine, suggesting that the underlying defect in this disease may relate to defective histamine metabolism or abnormal expression of histamine receptors on lymphocytes and leucocytes.