Robert C. Wolcott

AstraZeneca, Prilosec, and Nexium: Marketing Challenges in the Launch of a Second-Generation Drug

Tom McKillop, CEO of AstraZeneca, faced the classic quandary of large pharmaceutical firms. The firms patent for Prilosec (active ingredient omeprazole) was expiring. Severe cost-based competition from generic drug manufacturers was inevitable. Patent expirations were nothing new for the US

The Cambodian National HIV/AIDS Program: Successful Scale-Up through Innovation

15.8 billion in revenues drug firm, but Prilosec was the firms most successful drug franchise, with global sales of US

PTC: Launching an Entirely New Product Platform

6.2 billion. How could the company innovate its way around the generic cost-based competition and avoid the drop in revenues associated with generic drug market entry? AstraZeneca had other follow-on drugs in the pipeline—namely Nexium, an improvement on the original Prilosec molecule. Additionally, the company had the opportunity to introduce its own version of generic omeprazole, hence becoming the first mover in the generic segment, and/or introduce an OTC version of omeprazole that might tap into other markets. Ideally, AstraZeneca would like to move brand-loyal Prilosec customers to Nexium. In this market, direct-to-consumer advertising has remarkable efficacy. Classical marketing challenges of pricing and promotion need to be resolved for the Nexium launch as well as possible product and place challenges for the generic or OTC opportunity. Which combination of marketing options will allow the firm to best sustain the value of the original omeprazole innovation? The central objective of the case is to teach students how marketing variables can be used by first movers with diverse product portfolios to fend off severe price competition. These variables include pricing, promotion, product, and place (distribution) options as considered in the context of branded, generic, and OTC pharmaceutical market segments.

Wawa: Building a New Business within an Established Firm

In January 2005 Dr. Mean Chhi Vun, director of the Cambodian National Center for HIV/AIDS, Dermatology and STDs (NCHADS), needed to decide how to control the spread of HIV/AIDS and save the lives of thousands of Cambodians who were dying from it each year. In the seven years since Dr. Vun had been appointed director, NCHADS had built an organization that was transparent and efficient, had implemented a nationwide 100 percent Condom Use Program, had established a system that allowed individuals to voluntarily seek confidential counseling and testing, and had instituted a set of guidelines and procedures for staff at health facilities to refer HIV-positive patients to treatment clinics and link them with NGOs providing financial and psychosocial support. Now, however, Dr. Vun faced decisions about three initiatives that were critical to expanding care and treatment programs in his country. First, he needed to decide how to quickly and cost-effectively improve the national HIV/AIDS laboratory support infrastructure. Second, Dr. Vun needed to improve logistics and supply management in order to get the best prices and ensure patients had access to life-saving medicines. Finally, he needed to figure out how to provide sustainable care and treatment to the thousands of Cambodian children living with HIV/AIDS. Create innovative solutions for large-scale, socially relevant challenges. Understand how to start, scale, and lead cross-sector public health initiatives, or any initiative requiring behavior change by a range of players on a large scale over the long term. Discover and implement operating models that balance the needs of for-profit, non-profit, and government organizations. More effectively manage situations where required resources are not under ones direct control.

Thomson Financial: Building the Customer-Centric Firm

The case presents a

The 12 different ways for companies to innovate

1+billion technology company seeking new growth through the introduction of a radically new product platform. During its first ten years, PTC Corporation grew faster than Microsoft did during the similar period of its evolution. By the late 1990s PTC was faced with intensified competition and saturation in its core markets. To maintain growth, the company introduced a completely new product platform. While PTC focused on developing and selling the product, it failed to recognize that this new product was so different from its traditional offerings that it required a new organizational structure, sales capabilities, support processes, and market strategy. The case traces the companys evolution from development and launch of Windchill through the four-year period post-launch, during which its founding CEO was forced out and the company transformed. Ultimately, Windchill became a top seller for PTC, but not until after significant internal change. The PTC case illustrates what it means to build a new business within the context of an existing, successful firm. It can also be used to explore what it takes to accomplish a successful new product launch for a substantially new product platform. Sales and channel strategy also figures prominently in the case.

The Four Models of Corporate Entrepreneurship

Wawa, a

Grow from Within: Mastering Corporate Entrepreneurship and Innovation

4 billion privately held firm, is arguably the most successful convenience store operator in the United States. Explores how senior management decided to build an entirely new gasoline retailing business within the 100+-year-old firms core business of high-quality prepared foods and beverages. Charges students with defining the business and organization strategy necessary to “mainstream” the newly proven gasoline retailing concept throughout the company. To understand how corporate entrepreneurship occurs within established firms; redefine the core business—understanding organic growth beyond the core; and examine the critical role of leadership in any large-scale change process.

The seven myths of innovation

In December 1999 Thomson Financial (TF) began a radical transformation from forty-one divisions toward a more integrated firm organized around customer segments. This required active, coordinated involvement from business, organization, and technology functions, as well as sustained investment and execution through the crises of the technology market crash and September 11, 2001. By 2005 TF had emerged as one of the top three financial information firms globally (with Bloomberg and Reuters). Understand: 1. Building the customer-centric firm; “synchronizing” marketing (branding and sales), organizational, and technological infrastructure to focus on customer segments rather than products. 2. Making transformative, long-term investments under difficult circumstances. 3. Coordinating business, organization, and technology strategies throughout a long-term transformation process.