Robert E. Gaunt

Outcomes after ileal pouch anal anastomosis in patients with primary sclerosing cholangitis

BACKGROUND AND AIMS Outcomes after ileal pouch anal anastomosis (IPAA) are not well established in patients with primary sclerosing cholangitis (PSC). We conducted a comprehensive outcomes assessment in these patients. METHODS A retrospective case note review of complications in all PSC-IPAA (n=21) and matched ulcerative colitis patients with IPAA (UC-IPAA; n=79) after surgery in Oxford (1983-2012) was conducted, and functional outcomes (Öresland score) were evaluated (2012). Quality of life [Cleveland Global Quality of Life Questionnaire, Short Form-36 (SF-36)], and sexual function were also assessed (2012) including patients with PSC-associated UC without IPAA (PSC-UC; n=19). Sub-group analysis of patients with large duct (ld) PSC-IPAA (n=17) was also performed. RESULTS The 1-, 5-, 10- and 20-year risk of acute pouchitis for PSC-IPAA was 10%, 19%, 31% and 65% respectively, compared to 3%, 10%, 14% and 28% in UC-IPAA (p=0.03). More PSC-IPAA (36%) had poor nocturnal pouch function (vs 2% in UC-IPAA; p=0.0016). There were no differences in surgical complications, quality of life or sexual function between the 3 main groups. LdPSC-IPAA had poorer pouch function (Öresland score: 7.7 vs 5.4 in UC-IPAA; p=0.02), and worse quality of life [SF-36 Physical: 42 vs 50.5 in UC-IPAA; 47.7 in PSC-UC; p=0.03 and Mental Health summary scores: 41.6 vs 51.2 in UC-IPAA; 42.3 in PSC-UC; p=0.04]. CONCLUSIONS PSC-IPAA suffer more acute pouchitis and have worse functional outcomes than UC-IPAA. LdPSC-IPAA also have poorer quality of life.

On Stein’s method for products of normal random variables and zero bias couplings

In this paper we extend Steins method to the distribution of the product of

Inequalities for modified Bessel functions and their integrals

n

An iterative technique for bounding derivatives of solutions of Stein equations

independent mean zero normal random variables. A Stein equation is obtained for this class of distributions, which reduces to the classical normal Stein equation in the case

Products of normal, beta and gamma random variables: Stein operators and distributional theory

n=1

Rates of Convergence in Normal Approximation Under Moment Conditions Via New Bounds on Solutions of the Stein Equation

. This Stein equation motivates a generalisation of the zero bias transformation. We establish properties of this new transformation, and illustrate how they may be used together with the Stein equation to assess distributional distances for statistics that are asymptotically distributed as the product of independent central normal random variables. We end by proving some product normal approximation theorems.

Inequalities for Integrals of the Modified Struve Function of the First Kind

Abstract Simple inequalities for some integrals involving the modified Bessel functions I ν ( x ) and K ν ( x ) are established. We also obtain a monotonicity result for K ν ( x ) and a new lower bound, that involves gamma functions, for K 0 ( x ) .

A probabilistic proof of some integral formulas involving the Meijer G-function

We introduce a simple iterative technique for bounding derivatives of solutions of Stein equations

Identifying networks with common organizational principles

Lf=h-\mathbb{E}h(Z)

Comparison of large networks with sub-sampling strategies

, where