Robert Emmett Mcdevitt

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Featured researches published by Robert Emmett Mcdevitt.

Synthetic Communications | 2004

Chloromethyl sulfones from sulfonyl chlorides via a one-pot procedure

Schuyler Adam Antane; Ronald C. Bernotas; Yanfang Li; Robert Emmett Mcdevitt; Yinfa Yan

Abstract A simplified one‐pot transformation of a diverse set of aryl‐ and heteroaryl‐sulfonyl chlorides into the corresponding chloromethyl sulfones is described.

Bioorganic & Medicinal Chemistry | 2009

Dual acting norepinephrine reuptake inhibitors and 5-HT2A receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles

Gavin David Heffernan; Richard D. Coghlan; Eric S. Manas; Robert Emmett Mcdevitt; Yanfang Li; Paige Erin Mahaney; Albert J. Robichaud; Christine Huselton; Peter D. Alfinito; Jenifer A. Bray; Scott Cosmi; Grace H. Johnston; Thomas Kenney; Elizabeth Koury; Richard C. Winneker; Darlene C. Deecher; Eugene John Trybulski

The discovery of a series of 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles, dual acting norepinephrine reuptake inhibitors (NRIs) and 5-HT(2A) receptor antagonists, is described. The synthesis and structure-activity relationship (SAR) of this novel series of compounds is also presented.

Journal of Medicinal Chemistry | 2004

Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands.

Michael S. Malamas; Eric S. Manas; Robert Emmett Mcdevitt; Iwan Gunawan; Zhang B. Xu; Michael D. Collini; Christopher Miller; Tam Huynh Dinh; Ruth A. Henderson; James C. Keith; Heather A. Harris

Journal of Medicinal Chemistry | 2000

Novel Benzofuran and Benzothiophene Biphenyls as Inhibitors of Protein Tyrosine Phosphatase 1B with Antihyperglycemic Properties

Michael S. Malamas; Janet Sredy; Christopher Moxham; Alan H. Katz; Weixin Xu; Robert Emmett Mcdevitt; Folake Oluwemimo Adebayo; Diane R. Sawicki; Laura Seestaller; Donald Sullivan; Joseph R. Taylor

Archive | 1999

Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia

Michael Sotirios Malamas; Robert Emmett Mcdevitt; Folake Oluwemimo Adebayo

Bioorganic & Medicinal Chemistry Letters | 2005

Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones

Robert Emmett Mcdevitt; Michael S. Malamas; Eric S. Manas; Rayomand J. Unwalla; Zhang B. Xu; Chris P. Miller; Heather A. Harris

Archive | 2004

Substituted benzoxazoles as estrogenic agents

Michael S. Malamas; Robert Emmett Mcdevitt; Iwan Gunawan; Eric S. Manas; Michael D. Collini

Archive | 1999

2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia

John A. Butera; Craig Eugene Caufield; Russell Graceffa; Alexander Alexei Greenfield; Eric Gould Gundersen; Lisa Marie Havran; Alan H. Katz; Joseph R. Lennox; Scott Christian Mayer; Robert Emmett Mcdevitt

Archive | 2002

Substituted benzoxazoles and analogues as estrogenic agents

Michael Sotirios Malamas; Robert Emmett Mcdevitt; Iwan Gunawan; Eric S. Manas; Michael D. Collini; Heather A. Harris; James C. Keith; Leo M. Albert; Cecil R. Lyttle

Archive | 2002