Robert F. Hess

The threshold contrast sensitivity function in strabismic amblyopia: evidence for a two type classification.

Abstract Threshold contrast sensitivity functions for 10 representative strabismic amblyopes are presented. The results indicate that there are two classes of response. For one class, contrast sensitivity is depressed for only high spatial frequencies. For the other class, contrast sensitivity is depressed for all spatial frequencies, including low spatial frequencies; this response has not been previously reported. It is proposed that some results from the latter class are not simply extensions in severity of the former class and therefore two types of amblyopia need to be postulated.

The functional area for summation to threshold for sinusoidal gratings.

Abstract The contrast thresholds for sine-wave profile gratings were measured as a function of both the length of the bars and the number of bars of the grating. These factors were found to have a significant influence on threshold only when the resultant height and width was less than a size equivalent to ten periods of the grating at all spatial frequencies. This result suggests that there is a functional summation of responses of detecting elements at threshold over an area the size of which is reciprocally related to the spatial frequency. These data were used to measure the threshold contrast sensitivity functions for sine-wave and square-wave gratings under conditions where there are comparable field-sizes at each spatial frequency.

Deficits to global motion processing in human amblyopia.

We investigated global motion processing in a group of adult amblyopes using a method that allows us to factor out any influence of the known contrast sensitivity deficit. We show that there are independent global motion processing deficits in human amblyopia that are unrelated to the contrast sensitivity deficit, and that are more extensive for contrast-defined than for luminance-defined stimuli. We speculate that the site of these deficits must include the extra-striate cortex and in particular the dorsal pathway.

On the nature of the neural abnormality in human amblyopia; neural aberrations and neural sensitivity loss

In this investigation contrast threshold measurements are compared with supra-threshold perception for a group of human amblyopes. The results indicate that human amblyopia involves, in some cases, not only loss of sensitivity but spatial distortion. Thus a new group of amblyopes can now be identified in which only distortion occurs. These results have important physiological implications for both the normal and abnormal visual systems. Neurophysiologists investigating visual loss from deprivation should assess whether similar distortions occur in animals. This question may hold the answer to whether the present animal models are relevant to the human condition.

The cortical deficit in humans with strabismic amblyopia

To further our understanding of the cortical deficit in strabismic amblyopia, we measured, compared and mapped functional magnetic resonance imaging (fMRI) activation between the fixing and fellow amblyopic eyes of ten strabismic amblyopes. Of specific concern was whether the function of any visual area was spared in strabismic amblyopia, as recently suggested by both positron emission tomography (PET) and fMRI studies, and whether there was a close relationship between the fMRI response and known psychophysical deficits. To answer these questions we measured the psychophysical deficit in each subject and used stimuli whose relationship to the psychophysical deficit was known. We observed that stimuli that were well within the amblyopic passband did produce reduced fMRI activation, even in visual area V1. This suggests that V1 is anomalous in amblyopia. A similar level of reduction was observed in V2. In two subjects, we found that stimuli outside the amblyopic passband produced activation in visual area V3A. We did not find a close relationship between the fMRI response reduction in amblyopia and either of the known psychophysical deficits even though the fMRI response reduction in amblyopia did covary with stimulus spatial frequency.

Temporal properties of human visual filters: number, shapes and spatial covariation.

The temporal properties of the foveal visual filters were revealed using a method which is a variant on previously used noise masking paradigms. This enables the temporal properties of the mechanisms underlying threshold detection of a spatio-temporal probe to be measured. In accord with recent suggestions these results support the existence of three temporal mechanisms. The evidence for the third, higher temporal mechanism is only persuasive at low spatial frequencies. Furthermore, the results suggest that although there is some degree of spatio-temporal covariation in the filtering properties either of individual filters or across the filter population, the well known spatio-temporal covariation in human detection sensitivity is adequately explained by a sensitivity scaling of individual temporal filters with approximately invariant temporal properties.

Human peripheral spatial resolution for achromatic and chromatic stimuli: limits imposed by optical and retinal factors.

1. The aim of this study was to determine whether optical, receptoral or higher‐order neural properties limit spatial resolution (acuity) in human vision, especially in the peripheral regions of the visual field. 2. Both achromatic and chromatic stimuli were used, and measures were taken to ensure that the resolution estimates were not contaminated by the detection of spatial sampling artifacts. Spatial contrast sensitivity functions were measured at retinal locations from 0 to 55 deg along the naso‐temporal meridian for: (i) discriminating the direction of drift of luminance‐modulated (black‐white) sinusoidal stimuli drifting at 8 Hz (achromatic task); and (ii) for detecting isoluminant red‐green sinusoidal stimuli drifting at 0.4 Hz (chromatic task). Achromatic contrast sensitivity functions were also measured along the vertical meridian for eccentricities of 8 and 40 deg. Each achromatic function was extrapolated to a contrast sensitivity of one (100% contrast) to estimate achromatic acuity. Chromatic acuities were obtained by expressing chromatic contrast in terms of cone contrasts and using the same method of extrapolation. We compared the results with recent data on human optical properties and retinal anatomy. 3. Both achromatic and chromatic acuity decline with distance from the fovea, but at a faster rate than that dictated by the known optical and/or receptoral properties of the human eye. We conclude that, for stimuli of either achromatic or chromatic contrast, peripheral spatial resolution is limited by post‐receptoral mechanisms. Also, chromatic acuity declines more steeply than luminance acuity with eccentricity suggesting that there are additional post‐receptoral limitations on colour resolution in the periphery. 4. A clear naso‐temporal asymmetry is seen in the resolution whose dependence is qualitatively, but not quantitatively, similar to the Nyquist limits imposed by the asymmetric density of human retinal ganglion cells. We discuss the possibility that in peripheral vision (beyond the optic nerve head) the spacing of ganglion cells may pose a fundamental limit on the resolution of achromatic stimuli, but not chromatic stimuli.

Absence of contour linking in peripheral vision

Human foveal vision is subserved initially by groups of spatial, temporal and orientational ‘filters’, the outputs of which are combined to define perceptual objects. Although a great deal is known about the filtering properties of individual cortical cells, relatively little is known about the nature of this ‘linking’ process. One recent approach has shown that the process can be thought of in terms of an association field whose strength is determined conjointly by the orientation and distance of the object. Here we describe a fundamental difference in this feature-linking process in central and peripheral parts of the visual field, which provides insight into the ways that foveal and peripheral visual perception differ,. In the fovea, performance can be explained only by intercellular linking operations whereas in the periphery intracellular filtering will suffice. This difference represents a substantial economy in cortical neuronal processing of peripheral visual information and may allow a recent theory of intercellular binding to be tested.

The contrast sensitivity gradient across the human visual field: with emphasis on the low spatial frequency range

The regional variation of contrast sensitivity along the greater extent of each of the four principal hemi-meridia of the normal human eye was determined under photopic conditions using horizontally-orientated sinusoidal grating stimuli. The stimuli were well localized in space and frequency, and special attention was paid to the low spatial frequency range. The results confirm that contrast sensitivity is maximal for central vision for all test spatial stimuli. Extra-foveal fall-off in sensitivity can be represented as a linear function of eccentricity if the latter is expressed in relative units (i.e. periods of the stimulus). The regional variation parameter depends upon whether the horizontal or vertical field is tested and upon the spatial frequency of stimulation. The visible spatial frequency range (0.05-24 c/deg) can be approximately described by just three different rules. The fact that more than one rule is found bears upon current models of the functional organization of the visual system.

The spatial localization deficit in amblyopia

There have now been numerous reports of a spatial localization deficit in amblyopia but none so far have tackled (1) the relationship between the contrast sensitivity and spatial localization deficits and (2) whether the spatial localization deficit is best described in units of visual angle or in terms of the underlying filter size. These issues are germane because they lie at the very heart of our understanding of the underlying deficit in amblyopia. To answer these questions we use spatially bandpass stimuli so that we can readily compare detection and localization for the same stimuli at each of a number of spatial scales. For some amblyopes (all strabismics and a minority of anisometropes) the contrast sensitivity defect neither underlies nor covaries with the spatial localization deficit. In the majority of anisometropic amblyopes, the contrast sensitivity loss is a complete description. The spatial localization deficit in amblyopia is of two independent kinds; positional inaccuracy and positional distortion. The positional inaccuracy deficit which can occur in varying degrees in both strabismic and anisometropic amblyopia, affects all spatial scales equally and therefore is best thought of in terms of a constant fraction of the underlying filter size in the space-frequency plane. The positional distortion deficit which can also occur to varying degrees in both strabismic and anisometropic forms can not be easily understood within this metric at least for strabismics.