Robert Freedman
University of Utah
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Featured researches published by Robert Freedman.
Human Heredity | 1993
William Byerley; Hilary Coon; M. Hoff; John Holik; M. Waldo; Robert Freedman; Marc G. Caron; Bruno Giros
A large body of data suggests that perturbations in brain dopaminergic transmission play a role in the pathogenesis of schizophrenia. Recently, the gene for the human dopamine transporter has been cloned and polymorphisms have been identified. Because mutations of the dopamine transporter gene might underlie the cause of schizophrenia in a subset of families, we undertook a linkage analysis between schizophrenia in 9 families and a dopamine transporter gene polymorphism. Evidence of linkage was not found in most families assuming autosomal dominant or recessive inheritance.
Human Heredity | 1993
Steven Jensen; Rosemarie Plaetke; John Holik; M. Hoff; Marina Myles-Worsley; M. Leppert; Hilary Coon; Kevin Vest; Robert Freedman; M. Waldo; Qun-Yong Zhou; Mike Litt; Olivier Civelli; William Byerley
Alterations in dopaminergic activity may play an important role in the pathogenesis of schizophrenia. The central effects of dopamine are mediated by at least five G protein-coupled receptors, D1, D2, D3, D4 and D5. The D1 receptor maps to 5q35.1 and it identifies an Eco RI as well as a Taq I RFLP. In the present study we undertook a linkage analysis between the D1 receptor RFLPs and schizophrenia in 9 multigenerational families in which segregation of disease was consistent with autosomal dominant inheritance and reduced penetrance. Several flanking DNA markers were also analyzed as the D1 receptor RFLPs were relatively uninformative in our families. Pairwise analyses of schizophrenia and several flanking markers indicate that inheritability of this region is unlikely to be involved in the pathogenesis of schizophrenia in the 9 families studied.
Psychiatric Genetics | 1994
C. Pariseau; P. Gregor; Marina Myles-Worsley; John Holik; M. Hoff; M. Waldo; Robert Freedman; Hilary Coon; William Byerley
Nine multiplex schizophrenia familes were genotyped with polymorphisms for the GLUR5 and NMDAR1 glutamate receptor subunit genes. Using the lod score technique, evidence of linkage was not found assuming either dominant or recessive transmission. Similarly, the non-parametric sib pair test did not yield significant evidence of linkage.
Human Heredity | 1995
William Byerley; M. Hoff; John Holik; Marina Myles-Worsley; M. Waldo; Robert Freedman; Hilary Coon
Nine multiplex schizophrenia families were genotyped with seven highly polymorphic microsatellite loci used in the construction of an index map of chromosome 21. Assuming either autosomal dominant or recessive transmission, evidence of linkage was not found. In addition, the nonparametric sib-pair test did not yield significant evidence of linkage.
American Journal of Human Genetics | 2014
Jubao Duan; Jianxin Shi; Alessia Fiorentino; Catherine Leites; Xiangning Chen; Winton Moy; Jingchun Chen; Boian S. Alexandrov; Anny Usheva; Deli He; Jessica Freda; Niamh L. O’Brien; Pablo V. Gejman; Alan R. Sanders; Douglas F. Levinson; Nancy G. Buccola; Bryan J. Mowry; Robert Freedman; Ann Olincy; Farooq Amin; Donald W. Black; J. M. Silverman; William Byerley; Dragan M. Svrakic; C. Robert Cloninger; Michele T. Pato; Janet L. Sobell; Helena Medeiros; Colony Abbott; Brooke Skar
American Journal of Medical Genetics | 1993
Hilary Coon; M. Hoff; John Holik; Lynn E. DeLisi; Timothy Crowe; Robert Freedman; Gail Shields; Angela Boccio; Melissa Lerman; Elliot S. Gershon; Pablo V. Gejman; M. Leppert; William Byerley
Psychiatric Genetics | 1993
William Byerley; Rosemarie Plaetke; M. Hoff; S. Jensen; M. Leppert; John Holik; F. Reimherr; Paul H. Wender; M. Waldo; Marina Myles-Worsley; Robert Freedman; P. OʼConnell
Archive | 2003
Sherry Leonard; Robert Freedman
Archive | 1997
Sherry Leonard; Robert Freedman
Archive | 2001
Robert Freedman; Sherry Leonard; Ann Olincy; Charles A. Kaufmann; Dolores Malaspina; C. Robert Cloninger; Dragan M. Svrakic; Stephen V. Faraone; Ming T. Tsuang