Robert H. Furman

The influence of androgens, estrogens and related steroids on serum lipids and lipoproteins: Observations in hypogonadal and normal human subjects☆

T HERE are many diseases to which men are more vulnerable than women [ 71. The most important of these is coronary atherosclerosis. The frequency with which the chief clinical manifestations of this disorder are found in men exceeds that in women severalfold [2,3]. This sex differential was recognized almost two centuries ago when William Heberden, in his treatise on “Pectoris Dolor,” the classic description of the disease to which he gave the name “angina pectoris,” wrote: “I have seen nearly a hundred people under this disorder, of which number there have been three women, and one boy 12 years old. All the rest were men, near, or past the fiftieth year of age.”

THE INFLUENCE OF GONADAL HORMONES ON SERUM LIPIDS AND LIPOPROTEINS: STUDIES IN NORMAL AND HYPOGONADAL SUBJECTS

Anatomic studies such as those described by Sjovall and Wihman [4], Ackerman, Dry and Edwards [fl and Schlesinger and Zoll [S] indicate an earlier and more extensive degree of coronary atherosclerosis in the male, although the sex difference is less impressive than is the case with respect to the clinical manifestations. The concept of sex as a vulnerability factor in coronary atherosclerosis is lent further support

The Functional Circulatory Consequences of Myocardial Infarction A Biostatistical Analysis Following Wiggers' Schema

Excerpt Clinicians have known for almost 200 years that the manifestations of coronary atherosclerosis are much more frequent in men than in women. Numerous autopsy studies have disclosed the disea...

Renal function studies in acute syphilitic nephrosis before and after treatment with penicillin.

An analysis of what proportion of patients hospitalized with myocardial infarction follow the various circulatory pathways available and at what time in the course of the disease is presented. Patients who died with, but not necessarily because of, thrombosis or embolism outside the coronary vascular bed were withdrawn from the analysis. Almost half of the patients were able to resume usual or lighter activity and to enjoy, after two years, a survival rate similar to a Tennessee population of the same age, sex and racial distribution.

Plasma tocopherol levels in cardiac patients.

Excerpt Syphilis of the kidney includes a variety of renal lesions, none of which is well defined pathologically. The most common of these conditions, with the exception of slight and uncomplicated...

Metabolic and Serum Lipid Effects of Methylandrostane and Methylandrostene Pyrazoles

Abstract 1. 1. The average plasma tocopherol level in sixty-two patients with heart disease was 0.94 mg. per cent, a value which was significantly lower than the mean of 1.09 mg. per cent found in twenty-one healthy young adults. In addition, there was a greater incidence of very low levels among the cardiac patients. 2. 2. The plasma tocopherol level was determined in forty-two patients constituting a random sample of the hospital population, and an average value of 0.92 mg. per cent was obtained. This value was also signficantly lower than that in normal subjects, but was essentially the same as that found among cardiac patients. Furthermore, the incidence of low tocopherol levels was no greater in patients with heart disease than in hospital patients in general. In so far as plasma tocopherol levels are a measure of tocopherol nutrition, no evidence was found for differences between tocopherol nutrition in cardiac patients and that in other patients picked at random from the general hospital population. 3. 3. Tocopherol levels of patients in each of the four cardiac classes were essentially similar. No relationship was found between the tocopherol level and the severity of cardiac impairment. 4. 4. No correlation was found between the tocopherol level and sex or color, but there was a positive correlation between the tocopherol level and age.