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Robert J. Gordon

Rensselaer Polytechnic Institute

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Featured researches published by Robert J. Gordon.

Bioorganic & Medicinal Chemistry Letters | 1995

The design of potent and stable benzisothiazolone inhibitors of human leukocyte elastase

Dennis J. Hlasta; Malcolm R. Bell; John J. Court; Kenneth C. Cundy; Ranjit C. Desai; Edward Ferguson; Robert J. Gordon; Virendra Kumar; Alan L. Maycock; Chakrapani Subramanyam; Richard P. Dunlap; Shari L. Eiff; Catherine A. Franke; Albert J. Mura; Anne G. Rowlands

Abstract The lead compound for this SAR study, benzisothiazolone 1a, was a 15 nM inhibitor of HLE, but was unstable in human blood ( t 1 2 min). The introduction of lipophilic substituents at the R4-position such as ethyl or isopropyl and modulation of the electrophilicity of the benzisothiazolone carbonyl led to the identification of a potent ( K i ∗ =0.27 nM) and blood stable ( t 1 2 =260 min) inhibitor 2e, WIN 63395.

Journal of Medicinal Chemistry | 1995

Cyclooxygenase-2 Inhibitors. Synthesis and Pharmacological Activities of 5-Methanesulfonamido-1-indanone Derivatives

Chun Sing Li; Black Wc; Chi-Chung Chan; Ford-Hutchinson Aw; Gauthier Jy; Robert J. Gordon; Daniel Guay; Stacia Kargman; Lau Ck; Joseph A. Mancini

Journal of Medicinal Chemistry | 1999

2,3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors.

W. C. Black; Christine Brideau; Chi-Chung Chan; S. Charleson; Nathalie Chauret; D. Claveau; Diane Ethier; Robert J. Gordon; Gillian Greig; Jocelyne Guay; Gregory Hughes; P. Jolicoeur; Yves Leblanc; Deborah A. Nicoll-Griffith; N. Ouimet; Denis Riendeau; Denise M. Visco; Zhaoyin Wang; Lijing Xu; Petpiboon Prasit

Journal of Medicinal Chemistry | 1994

2,6-Disubstituted aryl carboxylic acids, leaving groups par excellence for benzisothiazolone inhibitors of human leukocyte elastase

Chakrapani Subramanyam; Malcolm R. Bell; Philip M. Carabateas; John J. Court; John A. Dority; Edward Ferguson; Robert J. Gordon; Dennis J. Hlasta; Kumar; Manohar Saindane

Journal of Medicinal Chemistry | 1995

Orally bioavailable benzisothiazolone inhibitors of human leukocyte elastase.

Dennis J. Hlasta; Chakrapani Subramanyam; Malcolm R. Bell; Philip M. Carabateas; John J. Court; Ranjit C. Desai; Drozd Ml; Eickhoff Wm; Edward Ferguson; Robert J. Gordon

Journal of Medicinal Chemistry | 1991

5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones.

Dennis J. Hlasta; Francis B. Casey; Edward Ferguson; Sally J. Gangell; Martha R. Heimann; Edward P. Jaeger; Rudolph K. Kullnig; Robert J. Gordon

Journal of Medicinal Chemistry | 1995

Phosphonates and phosphinates: novel leaving groups for benzisothiazolone inhibitors of human leukocyte elastase.

Ranjit C. Desai; John C. Court; Edward Ferguson; Robert J. Gordon; Dennis J. Hlasta; Richard P. Dunlap; Catherine A. Franke

Drug Development Research | 1992

Low molecular weight analogs of trolox with potent antioxidant activity in vitro and in vivo

Paul J. Silver; Robert J. Gordon; Patrick Horan; Cynthia R. Bushover; William Gorczyca; John R. Etzler; R.Allan Buchholz; Donald Charles Schlegel; George J. Ellames; David I. Smith; Alan M. Ezrin

Annals of the New York Academy of Sciences | 1991

Pulmonary Hemorrhage Induced by Intratracheal Administration of Human Leukocyte Elastase in Hamsters

Robert J. Gordon; Edward Ferguson; Richard P. Dunlap; Catherine A. Franke; Paul J. Silver

Bioorganic & Medicinal Chemistry Letters | 1997

Synthesis and biological evaluation of 5,6-diarylimidazo62.1-b9thiazole as selective COX-2 inhibitors

Michel Therien; Christine Brideau; Chi-Chung Chan; Wanda Cromlish; Jacques Yves Gauthier; Robert J. Gordon; Gillian Greig; Stacia Kargman; Cheuk K. Lau; Yves Leblanc; Chun-Sing Li; Gary P. O'Neill; Denis Riendeau; Patrick Roy; Zhaoyin Wang; Lijing Xu; Petpiboon Prasit

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Edward Ferguson

Rensselaer Polytechnic Institute

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Dennis J. Hlasta

Yale University

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Catherine A. Franke

Eastman Kodak Company

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Chakrapani Subramanyam

Pfizer

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Chi-Chung Chan

Merck

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John J. Court

Rensselaer Polytechnic Institute

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Malcolm R. Bell

Rensselaer Polytechnic Institute

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Paul J. Silver

University of Texas System

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Ranjit C. Desai

Merck

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Richard P. Dunlap

Eastman Kodak Company

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