Robert J. Letchford

Safe handling of organolithium compounds in the laboratory

Abstract Organolithium compounds are extremely useful reagents in organic synthesis and as initiators in anionic polymerizations. These reagents are corrosive, flammable, and in certain cases, pyrophoric. Careful planning prior to execution of the experiment will minimize hazards to personnel and the physical plant. The proper personal protective equipment (PPE) for handling organolithium compounds will be identified. Procedures to minimize contact with air and moisture will be presented. Solutions of organolithium compounds can be safely transferred from the storage bottles to the reaction flask with either a syringe or a cannula. With the utilization of these basic techniques, organolithium compounds can be safely handled in the laboratory.