Robert J. Oakland

A biomechanical investigation of vertebroplasty in osteoporotic compression fractures and in prophylactic vertebral reinforcement.

Study Design. Cadaveric single vertebrae were used to evaluate vertebroplasty as a prophylactic treatment and as an intervention for vertebral compression fractures. Objective. To investigate the biomechanical characteristics of prophylactic reinforcement and postfracture augmentation of cadaveric vertebrae. Summary of Background Data. Percutaneous vertebroplasty is a treatment option for osteoporotic vertebral compression fractures. Short-term results are promising, but longer-term studies have suggested a possible accelerated failure rate in the adjacent vertebral body. Limited research has been conducted into the effects of prophylactic vertebroplasty in osteoporotic vertebrae. This study aims to elucidate the biomechanical differences between the 2 treatment groups. Methods. Human vertebrae were assigned to 2 scenarios: Scenario 1 simulated a wedge fracture followed by cement augmentation; Scenario 2 involved prophylactic augmentation using vertebroplasty. Micro-CT imaging was performed to assess the bone mineral density, vertebral dimensions, fracture pattern, and cement volume. All augmented specimens were then compressed under an eccentric flexion load to failure. Results. Product of bone mineral density and endplate surface area gave a good prediction of failure strength when compared with actual failure strength of specimens in Scenario 1. Augmented vertebral bodies showed an average cement fill of 23.9% ± 8.07%. There was a significant postvertebroplasty increase in failure strength by a factor of 1.72 and 1.38 in Scenarios 1 and 2, respectively. There was a significant reduction in stiffness following augmentation for Scenario 1 (t = 3.5, P = 0.005). Stiffness of the vertebral body in Scenario 2 was significantly greater than observed in Scenario 1 (t = 4.4, P = 0.0002). Conclusion. Results suggest that augmentation of the vertebrae postfracture significantly increases failure load, while stiffness is not restored. Prophylactic augmentation was seen to increase failure strength in comparison to the predicted failure load. Stiffness appears to be maintained suggesting that prophylactic vertebroplasty maintains stiffness better than vertebroplasty postfracture.

Development of specimen-specific finite element models of human vertebrae for the analysis of vertebroplasty:

Abstract The aim of this study was to determine the accuracy of specimen-specific finite element models of untreated and cement-augmented vertebrae by direct comparison with experimental results. Eleven single cadaveric vertebrae were imaged using micro computed tomography (mCT) and tested to failure in axial compression in the laboratory. Four of the specimens were first augmented with PMMA cement to simulate a prophylactic vertebroplasty. Specimen-specific finite element models were then generated using semi-automated methods. An initial set of three untreated models was used to determine the optimum conversion factors from the image data to the bone material properties. Using these factors, the predicted stiffness and strength were determined for the remaining specimens (four untreated, four augmented). The model predictions were compared with the corresponding experimental data. Good agreement was found with the non-augmented specimens in terms of stiffness (root-mean-square (r.m.s.) error 12.9 per cent) and strength (r.m.s. error 14.4 per cent). With the augmented specimens, the models consistently overestimated both stiffness and strength (r.m.s. errors 65 and 68 per cent). The results indicate that this method has the potential to provide accurate predictions of vertebral behaviour prior to augmentation. However, modelling the augmented bone with bulk material properties is inadequate, and more detailed modelling of the cement region is required to capture the bone—cement interactions if the models are to be used to predict the behaviour following vertebroplasty.

Preliminary biomechanical evaluation of prophylactic vertebral reinforcement adjacent to vertebroplasty under cyclic loading

BACKGROUND CONTEXT Percutaneous vertebroplasty has become a favored treatment option for reducing pain in osteoporotic patients with vertebral compression fractures (VCFs). Short-term results are promising, although longer-term complications may arise from accelerated failure of the adjacent vertebral body. PURPOSE To provide a preliminary biomechanical assessment of prophylactic vertebral reinforcement adjacent to vertebroplasty using a three-vertebra cadaveric segment under dynamic loads that represent increasing activity demands. In addition, the effects of reducing the elastic modulus of the cement used in the intact vertebrae were also assessed. STUDY DESIGN/SETTING Three-vertebra cadaveric segments were used to evaluate vertebroplasty with adjacent vertebral reinforcement as an intervention for VCFs. METHODS Nine human three-vertebra segments (T12-L2) were prepared and a compression fracture was generated in the superior vertebrae. Vertebroplasty was performed on the fractured T12 vertebra. Subsequently, the adjacent intact L1 vertebra was prophylactically augmented with cement of differing elastic moduli (100-12.5% modulus of the base cement value). After subfailure quasi-static compression tests before and after augmentation, these specimens were subjected to an incrementally increasing dynamic load profile in proportion to patient body weight (BW) to assess the fatigue properties of the construct. Quantitative computed tomography assessments were conducted at several stages in the experimental process to evaluate the vertebral condition and quantify the gross dimensions of the segment. RESULTS No significant difference in construct stiffness was found pre- or postaugmentation (t=1.4, p=.19). Displacement plots recorded during dynamic loading showed little evidence of fracture under normal physiological loads or moderate activity (1-2.5x BW). A third of the specimens continued to endure increasing load demands and were confirmed to have no fracture after testing. In six specimens, however, greater loads induced 11 fractures: 7 in the augmented vertebra (2xT12, 5xL5) and 4 in the adjacent L2 vertebra. A strong correlation was observed between the subsidence in the segmental unit and the incidence of fracture after testing (r(Spearmans)=-0.88, p=.002). Altering the modulus of cement in the intact vertebra had no effect on level of segmental compromise. CONCLUSIONS These preliminary findings suggest that under normal physiological loads associated with moderate physical activity, prophylactic augmentation adjacent to vertebroplasty showed little evidence of inducing fractures, although loads representing more strenuous activities may generate adjacent and peri-augmentation compromise. Reducing the elastic modulus of the cement in the adjacent intact vertebrae appeared to have no significant effect on the incidence or location of the induced fracture or the overall height loss of the vertebral segment.

The biomechanical effectiveness of prophylactic vertebroplasty: a dynamic cadaveric study.

OBJECT The purpose of the study was to investigate the segmental effects of prophylactic vertebroplasty under increasingly demanding loading conditions and to assess the effect of altered cement properties on the construct biomechanics. METHODS Twelve human cadaveric 3-vertebral functional spinal units (T12-L2) were prepared such that the intact L-1 vertebra was prophylactically augmented with cements of differing elastic moduli (100, 50, 25, and 12.5% modulus of the base cement). These specimens were subjected to quasistatic subfailure compression pre- and postaugmentation to 50% of the predicted failure strength and then cyclic loading in a fatigue rig (115,000 cycles) to characterize the high-stress, short-cycle fatigue properties of the construct. Loading was increased incrementally in proportion to body weight to a maximum of 3.5 x body weight. Quantitative computed tomography assessment was conducted pre- and postaugmentation and following cyclic testing to assess vertebral condition, cement placement, and fracture classification. RESULTS Adjacent and periaugmentation fractures were induced in the prophylactically augmented segments. However, it appeared that these fractures mainly occurred when the specimens were subjected to loads beyond those that may commonly occur during most normal physiological activities. CONCLUSIONS Lowering the elastic modulus of the cement appeared to have no significant effect on the frequency or severity of the induced fracture within the vertebral segment.

The biomechanics of vertebroplasty in multiple myeloma and metastatic bladder cancer: a preliminary cadaveric investigation

OBJECT The vertebral column is the most common site for secondary bone metastases and lesions arising from hematological malignancies such as multiple myeloma (MM). These infiltrations can be lytic in nature and cause severe weakening of the vertebral body, an increased risk of fracture, and spinal cord compression leading to neurological deficit. Qualitatively it is apparent that increasing infiltration of these lytic lesions will have a deleterious effect on the mechanical behavior of the vertebrae. However, there is little quantitative information about the relationship between tumor deposits and the impact on the mechanical behavior of the vertebrae. In addition, there have been limited biomechanical assessments of the use of vertebroplasty in the management of these malignancies. The purpose of this preliminary study was to evaluate the mechanical behavior of lesion-infiltrated vertebrae from 2 malignant cancers and to investigate the effectiveness of vertebroplasty with and without tumor debulking. METHODS Individual vertebrae from 2 donor spines--one with MM and another with bone metastases secondary to bladder cancer-were fractured under an eccentric flexion load, from which failure strength and stiffness were derived. Alternate vertebrae defined by spinal level were assigned to 2 groups: Group 1 involved removal of lesion material with Coblation (ArthroCare Corp.) preceding vertebroplasty; Group 2 received no Coblation prior to augmentation. All vertebrae were fractured postaugmentation under the same loading protocol. Micro-CT assessments were undertaken to investigate vertebral morphology, fracture patterns, and cement distribution. RESULTS Multiple myeloma involvement was characterized by several small lesions, severe bone degradation, and multiple areas of vertebral shell compromise. In contrast, large focal lesions were present in the vertebrae with metastatic bladder cancer, and the shell generally remained intact. The mean initial failure strength of the vertebrae with metastases secondary to MM was significantly lower than in vertebrae with bone metastases secondary to bladder cancer (Load = 950 +/- 300 N vs 2200 +/- 750 N, p < 0.0001). A significant improvement in relative fracture strength was found postaugmentation for both lesion types (1.4 +/- 0.5, p < 0.001). Coblation provided a marginally significant increase in the same parameter postaugmentation (p = 0.08) and qualitatively improved the ease of injection and guidance of cement. CONCLUSIONS In the vertebral column, metastatic lesions secondary to bladder cancer and MM showed variations in the pattern of infiltration, both of which led to significant reductions in fracture strength. Account should be taken of these differences to optimize the vertebroplasty intervention in terms of the cement formulation, delivery, and any additional surgical procedure.

Vertebroplasty: Patient and treatment variations studied through parametric computational models☆

Background Vertebroplasty is increasingly used in the treatment of vertebral compression fractures. However there are concerns that this intervention may lead to further fractures in the adjacent vertebral segments. This study was designed to parametrically assess the influence of both treatment factors (cement volume and number of augmentations), and patient factors (bone and disc quality) on the biomechanical effects of vertebroplasty. Methods Specimen-specific finite element models of two experimentally-tested human three-vertebral-segments were developed from CT-scan data. Cement augmentation at one and two levels was represented in the respective models and good agreement in the predicted stiffness was found compared to the corresponding experimental specimens. Parametric variations of key variables associated with the procedure were then studied. Findings The segmental stiffness increased with disc degeneration, with increasing bone quality and to a lesser extent with increasing cement volume. Cement modulus did not have a great influence on the overall segmental stiffness and on the change in the elemental stress in the adjoining vertebrae. However, following augmentation, the stress distribution in the adjacent vertebra changed, indicating possible load redistribution effects of vertebroplasty. Interpretation This study demonstrates the importance of patient factors in the outcomes of vertebroplasty and suggests that these may be one reason for the variation in clinical results.

FE MODELS OF AUGMENTED HUMAN VERTEBRAE; EFFECT OF ASSIGNING BULK PROPERTIES FOR INJECTED CEMENT

Vertebroplasty is increasingly used for the treatment of vertebral compression factures. Although short term procedural results have been very favourable, longer-term clinical studies emerging now suggest adverse issues. Finite element(FE) techniques have been employed by a number of authors to examine vertebroplasty. In the majority of cases, the cement has been modelled as a homogeneous continuum mass within the vertebra, but this has not been validated against experimental data. Hence the objective of this study was to establish the levels of accuracy of subjectspecific finite element models of individual vertebrae with and without cement augmentation, and thereby understand the effect of employing bulk material models for the injected cement.

FE MODELS OF HUMAN VERTEBRAE; EFFECT OF IMAGE- BASED MATERIAL PROPERTY ASSIGNMENT METHODS

Osteoporosis vertebrae is susceptible to failure under physiological loading regimes. Prediction and assessment of risks associated with these failures is highly favourable for the clinicians in the selection and application of various therapeutic measures. Finite element (FE) models may improve clinical predictions of loading on vertebrae, especially stresses and strains produced in the tissues that cannot be measured experimentally. However, these models’ accuracy and reliability depend on the geometry, material properties and boundary conditions selected. Due to the complex nature of these entities, it is common to base the FE models on simplified loading or material properties (Crawford 2003, Guo 2005). The aim of this study was to examine the effect of various methods for assigning material properties in the FE models on the predictions derived.