Robert L. Maher

Clinical consequences of polypharmacy in elderly.

Introduction: Polypharmacy, defined as the use of multiple drugs or more than are medically necessary, is a growing concern for older adults. MEDLINE and EMBASE databases were searched from January 1, 1986 to June 30, 2013) to identify relevant articles in people aged > 65 years. Areas covered: We present information about: i) prevalence of polypharmacy and unnecessary medication use; ii) negative consequences of polypharmacy; and iii) interventions to improve polypharmacy. Expert opinion: International research shows that polypharmacy is common in older adults with the highest number of drugs taken by those residing in nursing homes. Nearly 50% of older adults take one or more medications that are not medically necessary. Research has clearly established a strong relationship between polypharmacy and negative clinical consequences. Moreover, well-designed interprofessional (often including clinical pharmacist) intervention studies that focus on enrolling high-risk older patients with polypharmacy have shown that they can be effective in reducing aspects of unnecessary prescribing with mixed results on distal health outcomes.

Reconsideration of Key Articles Regarding Medication Related Problems in Older Adults from 2011

This year, the oldest baby boomers turned 65 years of age. Baby boomers, which include individuals born between 1946 and 1964, represent 25% of the US population.1 In addition, given their life experiences, this group of individuals is likely to have higher expectations for the quality of health care services, including medication safety. Thus, it is timely to discuss what new knowledge on often preventable medication-related problems (i.e., medication errors and medication adverse events) in older adults was published in 2011. Hopefully, by doing so we can begin to develop approaches to reduce medication-related problems and meet this cohort’s expectations.

The Pharmacological Approach of Behavioral Disturbances in Dementia

Behavioral and psychological symptoms in dementia (BPSD) are often overlooked due to the main focus of treating or preventing cognitive decline symptoms. Almost two-thirds of patients with dementia will develop some type of noncognitive symptoms that include symptoms such as wandering, agitation, sexually inappropriate behaviors, physical and verbal aggression, uncooperativeness, and “sun-downing.” Psychological symptoms include depression, anxiety, delusions, hallucinations, and suspiciousness/paranoia. Worsening of these symptoms can lead to caregiver burden and is one of the major reasons for patients with dementia to be institutionalized. A major drawback of treating these symptoms pharmacologically is that the response rate is low with the current available therapies such as antipsychotics, anxiolytics, and antidepressants. In addition, all of these therapeutic classes have drawbacks due to side effect profiles. This article provides an overview of the current recommendations for pharmacological approaches for the treatment of behavioral and psychological symptoms of dementia.

A Pharmacist Approach to Wellness Maintenance in the Community Elderly

Wellness prevention in the elderly has similar goals as prevention in nonelderly adults, which is to improve lifestyles and habits to prevent disease (primary prevention) or the progression of disease (secondary prevention). Pharmacists who interact with the community elderly have a great opportunity of helping to keep our elderly healthy and preventing lifelong chronic problems that can contribute to a decrease in function of activities of daily living (ADLs) and instrumental activities of daily living (IADLs). This article focuses on the key prevention interventions that a pharmacist can target in helping to promote health maintenance.