Robert M. Heintz | Researchain

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Featured researches published by Robert M. Heintz.

Bioorganic & Medicinal Chemistry Letters | 2007

Design of potent inhibitors of human beta-secretase. Part 2.

John N. Freskos; Yvette M. Fobian; Timothy E. Benson; Joseph B. Moon; Michael J. Bienkowski; David L. Brown; Thomas L. Emmons; Robert M. Heintz; Alice Laborde; Joseph J. Mcdonald; Brent V. Mischke; John M. Molyneaux; Patrick B. Mullins; D. Bryan Prince; Donna J. Paddock; Alfredo G. Tomasselli; Greg Winterrowd

We describe an optimized series of acyclic hydroxyethylamine transition state isosteres of beta-secretase that incorporates a variety of P(2) side chains that yield potent inhibitors with excellent cellular activity. A 2.2A crystal structure of compound 13 is shown.

Journal of Medicinal Chemistry | 1993

Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere.

Daniel P. Getman; Gary A Decrescenzo; Robert M. Heintz; Reed Kl; John J. Talley; Martin L. Bryant; Michael Clare; Kathryn Houseman; Marr Jj; Richard A. Mueller

Journal of Medicinal Chemistry | 2005

Synthesis and structure-activity relationships of β- and α-piperidine sulfone hydroxamic acid matrix metalloproteinase inhibitors with oral antitumor efficacy

Daniel P. Becker; Clara I. Villamil; Thomas E. Barta; Louis J. Bedell; Terri L. Boehm; Gary A Decrescenzo; John N. Freskos; Daniel P. Getman; Susan L. Hockerman; Robert M. Heintz; Susan C. Howard; Madeleine H. Li; Joseph J. Mcdonald; Chris P. Carron; Chris L. Funckes-Shippy; Pramod P. Mehta; Grace E. Munie; Craig Swearingen

Archive | 1993

Urea-containing hydroxyethylamine compounds as retroviral protease inhibitors

John J. Talley; Daniel P. Getman; Gary A Decrescenzo; Ko-Chung Lin; Michael L. Vazquez; Richard A. Mueller; Kathryn L. Reed; Robert M. Heintz; Michael Clare; John N. Freskos; Eric T. Sun

Official Gazette of the United States Patent and Trademark Office Patents | 1998

Thioaryl sulfonamide hydroxamic acid compounds

Daniel P. Getman; Daniel P. Becker; Thomas E. Barta; Clara I. Villamil; Susan L. Hockerman; Louis J. Bedell; Hui Li; John N. Freskos; Robert M. Heintz; Joseph J. McDonald; Gary A Decrescenzo

Archive | 1998

Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds

John N. Freskos; Terri L. Boehm; Brent V. Mischke; Robert M. Heintz; Joseph J. Mcdonald; Gary A Decrescenzo; Susan C. Howard

Bioorganic & Medicinal Chemistry Letters | 2011

MMP-13 selective alpha-sulfone hydroxamates: identification of selective P1' amides.

Yvette M. Fobian; John N. Freskos; Thomas E. Barta; Louis J. Bedell; Robert M. Heintz; Darren J. Kassab; James R. Kiefer; Brent V. Mischke; John M. Molyneaux; Patrick B. Mullins; Grace E. Munie; Daniel P. Becker

Bioorganic & Medicinal Chemistry Letters | 2007

Design of potent inhibitors of human -secretase. Part 1

Archive | 2003

Acides piperidinylsulfonylmethylhydroxamiques et piperazinylsulfonylmethylhydroxamiques et leur utilisation comme inhibiteurs de protease

Thomas E. Barta; Daniel Becker; Louis J. Bedell; Terri L. Boehm; David L. Brown; Jeffery N. Carroll; Yiyuan Chen; Yvette M. Fobian; John N. Freskos; Alan F. Gasiecki; Margaret L. Grapperhaus; Robert M. Heintz; Susan L. Hockerman; Darren J. Kassab; Ish K. Khanna; Stephen A. Kolodziej; Mark A. Massa; Joseph J. Mcdonald; Brent V. Mischke; Deborah A. Mischke; Patrick B. Mullins; Mark A. Nagy; Monica B. Norton; Joseph G. Rico; Michelle A. Schmidt; Nathan W. Stehle; John J. Talley; William F. Vernier; Clara I. Villamill; Lijuan Jane Wang

Archive | 1998