Robert Streicher

Nanosurfaces and nanostructures for artificial orthopedic implants

Nanomaterials and structures, such as nanoparticles, nanofibers, nanosurfaces, nanocoatings, nanoscaffolds and nanocomposites, are considered for various applications in orthopedics and traumatology. This review looks at proposed nanotechnology inspired applications for implants from the perspective of the orthopedic industry. Investigations support consistently the theory that most nanomaterials in various physical forms are able to enhance the cell response selectively for biological tissue integration or increase the strength and wear resistance of current orthopedic materials. At this stage, most of the studies are at the laboratory scale or in early in vivo testing. Significant basic and applied research and development is needed to realize their full clinical potential and biological, manufacturing, economic and regulatory issues have to be addressed. Nevertheless, a crucial factor for success is well-coordinated multimethod and multidiscipline teamwork with profound industrial and medical expertise.

Ceramics in THR Bearings: Behavior under Off-Normal Conditions

The use of ceramics bearings in total hip joint replacement (THR) has increased markedly in the last ten years thanks to the optimum wear behaviour of ceramic-on-ceramic bearings and of the high biological safety of ceramic wear debris. As the number of ceramic THR bearings is increasing, also the number of implants that experience off-normal working conditions, e.g. edge loading, third bodies in the joint, soft tissues laxity, dislocation/subluxation of the joint, increases. Under all such conditions the surface of the bearing can be damaged to variable extent, leading eventually to a limitation of the expected performances of the implant.

Influence of Molarity and Liquid/Powder Ratio on the Synthesis of a Calcium Phosphate Cement

Current calcium phosphate based cements (CPCs) for use as bone substi tutes provide the surgeon with a material that is readily formable and with mecha ni al properties similar to that of human bone. However, a better understanding of the influence of the component ma terials used is required in order to further develop these cements. This study investiga t the influence of varying the molarity and liquid-to-powder (L:P) ratio of the sodium phosphate (Na 2HPO4) accelerator on the mechanical, chemical and microstructural properties of a CPC.

Circulating Cytokines as Biological Indicators for PE and Ceramics Articulations

We studied the role of cytokines (TNF-α, IL-6,IL-1β, TGF-β) as markers of osteolysis in patients who underwent to a hip prosthesis implantation subdivided in two groups: group A with an ultrahigh molecular weight polyethylene (UHMWPE) insert articulating against a metal ball head , and group B with an all alumina ceramic combination. Profibrogenic (TGF-β) and pro-inflammatory cytokines (TNF-α, IL-6,IL-1β) are secreted by the periprosthetic synovial-like fibrous membrane in hip artificial implants. They are secreted by inflammatory activated cells and trigger the cascade of biochemical events leading to the activation of osteoclasts and bone resorption. A statistically significant increase of TGF-β serum levels was observed between TGF-β values in implanted patients as compared to normal subjects and between TGF-β values after versus before implantation in Group A. A progressive decrease in TNF-α and IL-6 serum levels has been observed in both Groups, when compared with the initial values before the implantation. IL-1β levels decreased up to 60 months after the implantation Our data suggest that monitoring circulating cytokines could be a good indicator for the proliferation and activity of the periprosthetic synovial-like membrane and potential osteolysis. This could allow for an adequate early treatment.