Robert Sundoro Wu

Evaluation of vinylsulfamides as sulfhydryl selective alkylation reagents in protein modification

The preparation of several model vinylsulfamides is described. Their excellent selective reactivity towards sulfhydryl group with regards to amino group has been demonstrated by the kinetics study between a model vinylsulfamide and cysteine or lysine at different pHs.

Development of a microparticle-based on-site immunoassay for the detection of atrazine in soil and water samples.

Atrazine is widely used as a herbicide in agriculture and has been identified as a major groundwater contaminant in the US. Because of the possible hazard associated with its usage, there is a need for an efficient and economic screening method for on-site field testing of atrazine and other s-triazine herbicides in soil and water. We have developed a rapid, on-site test for the detection of atrazine based on the principle of microparticle agglutination inhibition immunoassay. The test detects 50 microg kg(-1) (0.050 ppm) atrazine in soil samples with direct extraction and 1.0 microg L(-1) atrazine in water samples when coupled with solid phase extraction.

Unexpected reactions of dithiodiglycolic acid: isolation of a novel seven-membered ring system based on a 2-amino derivative of 7-oxo-6,7-dihydro-[1,4,5]oxadithiepine

Abstract A novel seven-membered ring was unexpectedly isolated from the coupling of dithiodiglycolic acid with 2.2 equiv. of N -hydroxysuccinimide, followed by addition of 0.25 equiv. of methyl (4-aminomethyl)benzoate hydrochloride ( 2 ) in the presence of 2 equiv. of triethylamine.