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Publication
Featured researches published by Robert W. Overell.
Nature Medicine | 1996
Stanley R. Riddell; Mark Elliott; Deborah Lewinsohn; Mark J. Gilbert; Linda Wilson; Sara Manley; Stephen D. Lupton; Robert W. Overell; Thomas C. Reynolds; Lawrence Corey; Philip D. Greenberg
The introduction and expression of genes in somatic cells is an innovative therapy for correcting genetic deficiency diseases and augmenting immune function. A potential obstacle to gene therapy is the elimination of such gene–modified cells by an immune response to novel protein products of the introduced genes. We are conducting an immunotherapy trial in which individuals seropositive for human immunodeficiency virus (HIV) receive CD8+ HIV–specific cytotoxic T cells modified by retroviral transduction to express a gene permitting positive and negative selection. However, five of six subjects developed cytotoxic T–lymphocyte responses specific for the novel protein and eliminated the transduced cytotoxic T cells. The rejection of genetically modified cells by these immunocompromised hosts suggests that strategies to render gene–modified cells less susceptible to host immune surveillance will be required for successful gene therapy of immunocompetent hosts.
Molecular and Cellular Biology | 1991
Stephen D. Lupton; Laurie L. Brunton; Victoria A. Kalberg; Robert W. Overell
The hygromycin phosphotransferase gene was fused in-frame with the herpes simplex virus type 1 thymidine kinase gene. The resulting fusion gene (termed HyTK) confers hygromycin B resistance for dominant positive selection and ganciclovir sensitivity for negative selection and provides a means by which these selectable phenotypes may be expressed and regulated as a single genetic entity.
Archive | 1995
Robert W. Overell; Karen E. Weisser
Archive | 1995
Ralph W. Paul; Robert W. Overell
Human Gene Therapy | 1997
Ralph W. Paul; Karen E. Weisser; Aaron Garth Loomis; David L. Sloane; Dan LaFoe; E. Morrey Atkinson; Robert W. Overell
Journal of Immunology | 1994
Satoshi Nagoya; Philip D. Greenberg; Cassian Yee; Karen E. Weisser; Hiroyuki Sugawara; Michael B. Widmer; Jennifer Slack; Steven K. Dower; Stephen D. Lupton; Robert W. Overell
Archive | 1995
Robert W. Overell; Karen E. Weisser
Archive | 1994
Ralph W. Paul; Robert W. Overell
Archive | 1991
Philip D. Greenberg; Robert W. Overell
Archive | 1991
Philip D. Greenberg; Robert W. Overell