Robert W. Sappenfield

Stilbazium Iodide (Monopar) An Effective, Single Dose Anthelminthic for Treatment of Enterobius vermicularis Infection

This work was supported by funds from The Burroughs Wellcome Co., Inc. procedure was performed as described by Hunter, Frye and Swartzwelder (1960). The drug employed was stilbazium iodide, a tasteless nearly insoluble quaternary pyridine with the chemical name of 2,6-Bis-(j!?-pyrrolidinostyryl)pyridine ethiodide. It was administered in gelatin capsules. The dosages used were 5 mg.Jk~. and 10 mg./Kg. body weight, with a maximum dose of 750 mg. No specific hygienic meas-

Broad-spectrum intestinal anthelmintic activity of dithiazanine

SummaryThe principle of effective broad-spectrum anthelmintic activity against human intestinal nematode infections has been demonstrated by the therapeutic results obtained with dithiazanine. In proper dosage, this polyvermicide is therapeutic for trichuriasis, strongyloidiasis, ascariasis and enterobiasis. The drug has only moderate anthelmintic activity against the hookworm,Necator americanus. It fills a need for a therapeutic for trichuriasis and strongyloidiasis. Dithiazanine is useful for the treatment of patients with either single or multiple intestinal helminthic infections.The indications for use of dithiazanine iodide are:1.Trishuriasis2.Strongyloidiasis3.Mixed infections with trichuriasis and ascariasis4.Other mixed infections with intestinal nematodes when either trichuriasis or strongyloidiasis is present.