Roberto J. Rona

Prevalence and trends in overweight and obesity in three cross sectional studies of British children, 1974-94

Abstract Objectives: To report trends in overweight and obesity, defined by new internationally agreed cut-off points, in children in the United Kingdom. Design: Three independent cross sectional surveys. Setting: Primary schools in England and Scotland. Participants: 10 414 boys and 9737 girls in England and 5385 boys and 5219 girls in Scotland aged 4 to 11 years. Main outcome measures: Prevalence and change in prevalence of overweight and obesity, as defined by the international obesity task force, in 1974, 1984, and 1994, for each sex and country. Results: Little change was found in the prevalence of overweight or obesity from 1974 to 1984. From 1984 to 1994 overweight increased from 5.4% to 9.0% in English boys (increase 3.6%, 95% confidence interval 2.3% to 5.0%) and from 6.4% to 10.0% in Scottish boys (3.6%, 1.9% to 5.4%). Values for girls were 9.3% to 13.5% (4.1%, 2.4% to 5.9%) and 10.4% to 15.8% (5.4%, 3.2% to 7.6%), respectively. The prevalence of obesity increased correspondingly, reaching 1.7% (English boys), 2.1% (Scottish boys), 2.6% (English girls), and 3.2% (Scottish girls). Conclusion: These results form a base from which trends can be monitored. The rising trends are likely to be reflected in increases in adult obesity and associated morbidity.

The health of UK military personnel who deployed to the 2003 Iraq war: a cohort study.

BACKGROUND Concerns have been raised about the mental and physical health of UK military personnel who deployed to the 2003 war in Iraq and subsequent tours of duty in the country. METHODS We compared health outcomes in a random sample of UK armed forces personnel who were deployed to the 2003 Iraq war with those in personnel who were not deployed. Participants completed a questionnaire covering the nature of the deployment and health outcomes, which included symptoms of post-traumatic stress disorder, common mental disorders, general wellbeing, alcohol consumption, physical symptoms, and fatigue. FINDINGS The participation rate was 62.3% (n=4722) in the deployed sample, and 56.3% (n=5550) in the non-deployed sample. Differences in health outcomes between groups were slight. There was a modest increase in the number of individuals with multiple physical symptoms (odds ratio 1.33; 95% CI 1.15-1.54). No other differences between groups were noted. The effect of deployment was different for reservists compared with regulars. In regulars, only presence of multiple physical symptoms was weakly associated with deployment (1.32; 1.14-1.53), whereas for reservists deployment was associated with common mental disorders (2.47, 1.35-4.52) and fatigue (1.78; 1.09-2.91). There was no evidence that later deployments, which were associated with escalating insurgency and UK casualties, were associated with poorer mental health outcomes. INTERPRETATION For regular personnel in the UK armed forces, deployment to the Iraq war has not, so far, been associated with significantly worse health outcomes, apart from a modest effect on multiple physical symptoms. There is evidence of a clinically and statistically significant effect on health in reservists.

The prevalence of plant food allergies: A systematic review

BACKGROUND There is uncertainty regarding the prevalence of allergies to plant food. OBJECTIVE To assess the prevalence of allergies to plant food according to the different subjective and objective assessment methods. METHODS Our systematic search of population-based studies (since 1990) in the literature database MEDLINE focused on fruits, vegetables/legumes, tree nuts, wheat, soy, cereals, and seeds. Prevalence estimates were categorized by food item and method used (food challenges, skin prick test, serum IgE, parent/self-reported symptoms), complemented by appropriate meta-analyses. RESULTS We included 36 studies with data from a total of over 250,000 children and adults. Only 6 studies included food challenge tests with prevalences ranging from 0.1% to 4.3% each for fruits and tree nuts, 0.1% to 1.4% for vegetables, and < 1% each for wheat, soy, and sesame. The prevalence of sensitization against any specific plant food item assessed by skin prick test was usually < 1%, whereas sensitization assessed by IgE against wheat ranged as high as 3.6% and against soy as high as 2.9%. For fruit and vegetables, prevalences based on perception were generally higher than those based on sensitization, but for wheat and soy in adults, sensitization was higher. Meta-analyses showed significant heterogeneity between studies regardless of food item or age group. CONCLUSION Population-based prevalence estimates for allergies to plant products determined by the diagnostic gold standard are scarce. There was considerable heterogeneity in the prevalence estimates of sensitization or perceived allergic reactions to plant food.

Effects of prematurity and intrauterine growth on respiratory health and lung function in childhood.

OBJECTIVE--To determine whether birth weight and gestational age are associated with respiratory illness and lung function in children aged 5-11 years. DESIGN--Cross sectional analysis of parent reported birth weight, gestational age, and respiratory symptoms; parental smoking and social conditions; forced vital capacity (FVC), forced expiratory volume in one second (FEV1), forced expiratory rates between 25% and 75% and 75% and 85% (FEF25-75 and FEF75-85), and height. SETTING--Primary schools in England and Scotland in 1990. SUBJECTS--5573 children aged 5-11 (63.3% of eligible children) had respiratory symptoms analysed and 2036 children (67.1% of eligible children) had lung function measured. MAIN OUTCOME MEASURES--Symptoms of asthma, bronchitis, occasional and frequent wheeze, cough first thing in the morning, and cough at any other time and lung function. RESULTS--Birth weight adjusted for gestational age was significantly associated with all lung function measurements, except FEF25-75. The association remained for FVC (b = 0.475, 95% confidence interval 0.181 to 0.769) and FEV1 (b = 0.502, 0.204 to 0.800) after adjustment for gestational age, parental smoking, and social factors. FEF75-85 was the only lung function related to gestational age. Respiratory symptoms, especially wheeze most days (adjusted odds ratio 0.9, 0.84 to 0.97) were significantly associated with prematurity. Every extra week of gestation reduced the risk of severe wheeze by about 10%. CONCLUSIONS--Lung function is affected mainly by intrauterine environment while respiratory illness, especially wheezing, in childhood is related to prematurity.

Overweight and obesity trends from 1974 to 2003 in English children: what is the role of socioeconomic factors?

Aims: To examine the childhood overweight and obesity prevalence trends between 1974 and 2003 and to assess whether these trends relate to parental social class and household income. Methods: A school based and a general population health survey: the National Study of Health and Growth in 1974, 1984, and 1994, and the Health Survey for England, yearly from 1996 to 2003. Participants were 14 587 white boys and 14 014 white girls aged 5–10 years. Overweight and obesity prevalence were calculated using UK specific as well as international body mass index (kg/m2) cut-offs. Socioeconomic status was measured using the Registrar General’s social class; household income (1997 onwards only) was adjusted for household size. Results: The prevalence of obesity (UK specific definition) in boys increased from 1.2% in 1984 to 3.4% in 1996–97 and 6.0% in 2002–03. In girls, obesity increased from 1.8% in 1984 to 4.5% in 1996–97 and 6.6% in 2002–03. Obesity prevalence has been increasing at accelerating rates in the more recent years. Children from manual social classes had marginally higher odds (OR 1.14, 95% CI 0.98 to 1.33) and children from higher income households had lower odds (OR 0.74, 95% CI 0.61 to 0.89) to be obese than their peers from non-manual class, and lower income households, respectively. Conclusion: Childhood obesity is increasing rapidly into the 2000s in England and these increases are more marked among children from lower socioeconomic strata. There is an urgent need for action to prevent further increase in obesity among children.

Can the increase in body mass index explain the rising trend in asthma in children

BACKGROUND The reported association between asthma and obesity and the documented rise in each over time have led to suggestions that rising obesity might explain the increase in the prevalence of asthma. Trends in both in British children participating in the National Study of Health and Growth were marked from 1982 to 1994. METHODS Odd ratios for trends in asthma and symptoms in 8 and 9 year old children were calculated with and without adjustment for body mass index (BMI). RESULTS In a representative sample of white children the odds ratio per year for asthma was 1.09 (95% CI 1.07 to 1.11) before and after adjustment for BMI for boys and 1.09 (95% CI 1.07 to 1.12) and 1.09 (95% CI 1.05 to 1.12), respectively, for girls. Unadjusted and adjusted odds ratios were also virtually identical for wheeze and “asthma or bronchitis”. The lack of effect of adjustment was due to a change in the association between BMI and symptoms with time. CONCLUSIONS Trends in overweight and obesity do not explain the increase in asthma. The evidence points towards the association between asthma and obesity being of recent origin. This may be explained by obesity being a marker of recent lifestyle differences now associated with both asthma and overweight.

PTSD after deployment to Iraq: conflicting rates, conflicting claims.

BACKGROUND Post-traumatic stress disorder (PTSD) has been called one of the signature injuries of the Iraq War. In this review prevalence estimates of PTSD are summarized and discrepancies are discussed in relation to methodological differences between studies. METHOD We searched for population-based studies with a minimum sample size of 300. Studies based on help-seeking samples were excluded. We identified 60 possible papers, of which 19 fulfilled the inclusion criteria. Prevalence estimates and study characteristics were examined graphically with forest plots, but because of high levels of heterogeneity between studies, overall estimates of PTSD prevalence were not discussed. RESULTS The prevalence of PTSD in personnel deployed to Iraq varied between 1.4% and 31%. Stratifying studies by PTSD measure only slightly reduced the variability in prevalence. Anonymous surveys of line infantry units reported higher levels of PTSD compared to studies that are representative of the entire deployed population. UK studies tend to report lower prevalence of PTSD compared with many US studies; however, when comparisons are restricted to studies with random samples, prevalences are similar. US studies that have assessed personnel more than once since return from deployment have shown that PTSD prevalence increases over the 12 months following deployment. CONCLUSIONS Differences in methodologies and samples used should be considered when making comparisons of PTSD prevalence between studies. Further studies based on longitudinal samples are needed to understand how the prevalence of PTSD changes over time.

The prevalence of common mental disorders and PTSD in the UK military: using data from a clinical interview-based study

BackgroundThe mental health of the Armed Forces is an important issue of both academic and public interest. The aims of this study are to: a) assess the prevalence and risk factors for common mental disorders and post traumatic stress disorder (PTSD) symptoms, during the main fighting period of the Iraq War (TELIC 1) and later deployments to Iraq or elsewhere and enlistment status (regular or reserve), and b) compare the prevalence of depression, PTSD symptoms and suicidal ideation in regular and reserve UK Army personnel who deployed to Iraq with their US counterparts.MethodsParticipants were drawn from a large UK military health study using a standard two phase survey technique stratified by deployment status and engagement type. Participants undertook a structured telephone interview including the Patient Health Questionnaire (PHQ) and a short measure of PTSD (Primary Care PTSD, PC-PTSD). The response rate was 76% (821 participants).ResultsThe weighted prevalence of common mental disorders and PTSD symptoms was 27.2% and 4.8%, respectively. The most common diagnoses were alcohol abuse (18.0%) and neurotic disorders (13.5%). There was no health effect of deploying for regular personnel, but an increased risk of PTSD for reservists who deployed to Iraq and other recent deployments compared to reservists who did not deploy. The prevalence of depression, PTSD symptoms and subjective poor health were similar between regular US and UK Iraq combatants.ConclusionThe most common mental disorders in the UK military are alcohol abuse and neurotic disorders. The prevalence of PTSD symptoms remains low in the UK military, but reservists are at greater risk of psychiatric injury than regular personnel.

Disturbed sleep: effects of sociocultural factors and illness

To assess the prevalence of sleep disturbance and associated risk factors, sleep patterns were analysed in 14 372 English and Scottish children. Approximately 4% of children aged 5 experienced disturbed sleep more than once a week, but this decreased to 1% from age 9. Less than 25% of the parents with an affected child consulted a doctor. Sleep disturbance was associated with persistent wheezing compared to non-wheezing children (odds ratio 4.42; 95% confidence interval (CI) 3.17 to 6.13), and more frequent in children of Indian subcontinent descent than in white children (odds ratio 2.20; 95% CI 1.34 to 3.60), and in children whose mother reached no more than primary education compared with those with higher education (odds ratio 2.41; 95% CI 1.51 to 3.84). Sociocultural factors associated with ethnicity and respiratory illness are important risk factors for sleeping disorders in childhood.

Asthma and poverty

If the UK Department of Healths “Independent inquiry into inequalities in health”1 had been carried out in the USA, asthma would probably have occupied a prominent place in the document. In Britain a review of the evidence on inequalities did not mention asthma as a health issue related to poverty. Americans review the association of asthma and poverty on a regular basis in the literature.2-7 Platt-Mills3 suggested that the link between low social class and asthma was a phenomenon restricted to the USA. Is this perception correct and, if so, why should it be? In reviewing the topic it is appropriate to disaggregate several related but separate components. Poverty may contribute to the aetiology, exacerbation, recognition, and management of asthma (box FB1). There is also a historical perspective that needs some consideration. In Britain both coronary heart disease and diabetes mellitus were initially more prevalent among the wealthy, but subsequently became associated with poverty. Studies based on more recent data may therefore show a different association between asthma and poverty than earlier work. Figure FB1 Possible effects of poverty on asthma   The nature and intensity of poverty differ between societies. In the USA financial barriers may prevent the poor from obtaining appropriate care and may limit the ability to purchase medication. In Britain financial barriers are less obvious and cultural differences between strata in society may be more relevant. It is important to consider whether we are dealing with structural poverty—that is, characteristics that are essential to being poor—or characteristics that are associated with the poorest groups in a country. Smoking, high indoor and outdoor pollution, obesity, family size, low birth weight and preterm delivery, characteristics of diet and ethnic background which, in varying degrees, have been found to be related to asthma, are also associated with poverty, …