Rodolfo Paoletti

Genome instability in cancer development

Part 1. The Problem of Genome Instability 1.1. The Multiplicity of Mutations in Human Cancers by Ranga N. Venkatesan and Lawrence A. Loeb 1.2. Monitoring chromosome rearrangements by Michael R. Speicher Part 2. DNA Repair and Mutagenesis 2.1. Nucleotide excision repair and its connection with cancer and ageing by Jaan-Olle Andressoo, Jan H.J. Hoeijmakers and Harm de Waard 2.2. DNA mismatch repair and colon cancer by Giancarlo Marra and Josef Jiricny 2.3. Base excision repair by Lisiane B. Meira, Nicholas E. Burgis and Leona D. Samson 2.4. DNA double strand break repair by Penny A. Jeggo 2.5. Translesion synthesis and error-prone polymerases by Catherine M. Green and Alan R. Lehmann Part 3. Cell Cycle Progression and Chromosome Aberrations 3.1. The INK4A/ARF network - cell cycle checkpoint or emergency brake? By Ana Gutierrez del Arroyo and Gordon Peters 3.2. DNA replication and genomic instability by Wenge Zhu, Tarek Abbas and Anindya Dutta 3.3. The dream of every chromosome: equal segregation for a healthy life of the host by Tomohiro Matsumoto and Mitsuhiro Yanagida 3.4. Telomere structural dynamics in genome integrity control and carcinogenesis by Roger A. Greenberg and K. Lenhard Rudolph 3.5. Gene amplification mechanisms by Michelle Debatisse and Bernard Malfoy 3.6. DNA methylation and cancer-associated genetic instability by Melanie Ehrlich 3.7. Deregulation of the centrosome cycle and the origin of chromosomal instability in cancer by Wilma L. Lingle, Kara Lukaswiewicz and Jeffrey L. Salisbury Part 4. Genome Integrity Checkpoints 4.1. Mammalian DNA damage response pathway by Zhenkun Lou and Junjie Chen 4.2. ATM and cellular response to DNA damage by Martin F Lavin, Sergei Kozlov, Nuri Gueven, Cheng Peng, Geoff Birrell, Phillip Chen and Shaun Scott 4.3 Kinetochore function, chromosome segregation and the spindle assembly checkpoint by Tim J. Yen and Gary D. Kao

Dipeptidyl Aminopeptidases in Health and Disease

Structure and Function of Dipeptidyl Aminopeptidases. Dipeptidyl Peptidase IV Substrates I. de Meester, et al. Structure-Function Relationship of DPP IV: Insights into its Dimerisation and Gelatinase Activity O. Baum, et al. Exploration of the Active Site of Dipeptidyl Peptidase IV From Porphyromonas gingivalis A.-M. Lambeir, et al. Modification of the Biological Activity of Chemokines by Dipeptidyl Peptidase IV - a Side Effect in the Use of Inhibitors? R. Mentlein, et al. Molecular Chimeras and Mutational Analysis in the Prolyl Oligopeptidase Gene Family K. Ajami, et al. The Specificity of DP IV for Natural Substrates is Peptide Structure Determined K. Kuhn-Wache, et al. New Results on the Conformations of Potent DP IV (CD26) Inhibitors Bearing the N-terminal MWP Structural Motif C. Mrestani-Klaus, et al. Different Inhibition Mechanisms of Dipeptidyl Peptidase IV by Tryptophan Containing Peptides and Amides A. Stockel-Maschek, et al. Re-Uptake Mechanisms of Peptide Fragments after DPP IV-Mediated Proteolysis in the Peripheral Nervous System Q. Thai Dinh, et al. DPP IV-Like Enzymes. Dipeptidyl Peptidase IV Gene Family Tong Chen, et al. Seprase-DPPIV Association and Prolyl Peptidase and Gelatinase Activities of the Protease Complex G. Ghersi, et al. Dipeptidyl Peptidase-IV Activity and/or Structure Homologues (DASH) in Transformed Neuroectodermal Cells R. Malik, et al. Characterisation of Human DP IV Produced by a Pichia pastoris Expression System J.W. Baer, et al. Isolation and Characterization of Attractin-2 D. Friedrich, et al. Investigation of DP IV-dependent Protein-Protein Interactions using Surface Plasmon Resonance J. Stork, et al. Immune Mechanisms andImmune Disorders. Synergistic Action of DPIV and APN in the Regulation of T Cell Function U. Lendeckel, et al. CD26/DPP IV in Experimental and Clinical Organ Transplantation S. Korom, et al. CD26 is Involved in the Regulation of T-Cell Plasma Membrane Compartmentation J. Lojo, et al. Inhibition of Dipeptidylpeptidase IV (DPP IV, CD26) Activity Modulates Surface Expression of CTLA-4 in Stress-Induced Abortions J. Ruter, et al. Dipeptidyl Peptidase IV/CD26 in T Cell Activation, Cytokine Secretion and Immunoglobulin Production Hua Fan, et al. Dipeptidyl Peptidase IV Inhibitors with the N-terminal MXP Sequence: Structure-Activity-Relationships J. Faust, et al. On the Role of Dipeptidyl Peptidase IV in the Digestion of an Immunodominant Epitope in Celiac Disease S. Koch, et al. The Properties of Human and Bovine CD8+CD26+ T Cells Induced by a Microbial Superantigen Sang-Un Lee, et al. Angiogenesis and Cancer. DPPIV and Seprase in Cancer Invasion and Angiogenesis W.-T. Chen. Glutamate Carboxypeptidase II Inhibition as a Novel Therapeutic Target C. Rojas, et al. Dual Role of Dipeptidyl Peptidase IV (DPP IV) in Angiogenesis and Vascular Remodeling J. Kitlinska, et al. CD26 Expression on Cutaneous Infiltrates from Patients with Cutaneous T-Cell Lymphoma (CTCL) M. Novelli, et al. Intrahepatic Expression of Collagen and Fibroblast Activation Protein (FAP) in Hepatitis C Virus Infection M.D. Gorrell, et al. Expression of CD26/Dipeptidyl Peptidase IV in Endometrial Adenocarcinoma and its Negative Correlation with Tumor Grade H. Kajiyama, et al. Adhesion Potency to Mesothelial Cells by Overexpression of Dipeptidyl Peptidase IV F. Kikkawa, et al. Survival Time and Invasive Activity due to Dipeptidyl Peptidase IV Overexpression in Ovarian C

Drugs affecting lipid metabolism VIII

Cellular Biology of Atherosclerosis.- The Cellular Pathobiology of Atherosclerosis in 1983.- Secretory Functions of the Mononuclear Phagocyte.- Risk Factors for the Development of Premature Cardiovascular Disease.- Fate of Cholesteryl Linoleyl Ether Injected into Rats as Chylomicrons, Acetylated LDL and HDL.- Hypertriglyceridemia: Lipoprotein Receptors and Atherosclerosis.- Hypertriglyceridemia and Atherosclerosis: Analysis of an Abnormal Lipoprotein System and Potential Beneficial Effects of Triglyceride Lowering Therapy.- Apolipoproteins.- The Role of Hydrophobicity in the Structure of the Human Plasma Lipoproteins.- Metabolism of Apolipoproteins and the Metabolic Heterogeneity of Apo B in the Rat.- Proapolipoprotein A-I Metabolism in the Human and the Rat.- Isolation and Characterization of the Apolipoprotein Genes.- Apoprotein Measurements.- Use of Monoclonal Antibodies in Studies of Lipoprotein Structure and Function.- Apolipoprotein E: Receptor Binding Properties.- Apolipoprotein E Mutants, Hyperlipidemia and Arteriosclerosis.- Noninvasive Assessment of Atherosclerosis.- Noninvasive Assessment of Atherosclerosis in Nonhuman Primates.- Noninvasive Assessment of Atherosclerosis: Studies in Man.- Noninvasive Atherosclerosis Assessment for Controlled Clinical Trials.- Drugs and Diet.- Strategy, Yield and Risks of Controlling Plasma Lipids in the Primary Prevention of Coronary Heart Disease.- Mechanisms of Action of Absorbable Hypolipidemic Drugs.- Dietary Factors Affecting Lipoprotein Metabolism.- Inhibition of Cholesterol Absorption by Natural Products.- Effects of Nicotinic Acid and Its Derivatives on Lipid Metabolism and Other Metabolic Factors Related to Atherosclerosis.- HMG-CoA Reductase Inhibitors.- The Role of Phosphorylation/Dephosphorylation in the Regulation of Cholesterol 7?-Hydroxylase Activity.- Calcium Antagonists and Atherosclerosis.- Management of Adherence to Prescribed Medication.- Meeting Summary.- Abstracts.- Abstracts.- Author Index.

ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY

Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields. Advances in Experimental Medicine and Biology has been publishing exceptional works in the field for over 40 years, and is indexed in SCOPUS, Medline (PubMed), Journal Citation Reports/Science Edition, Science Citation Index Expanded (SciSearch, Web of Science), EMBASE, BIOSIS, Reaxys, EMBiology, the Chemical Abstracts Service (CAS), and Pathway Studio. 2018 Impact Factor: 2.126.