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Dive into the research topics where Rogelio Menendez is active.

Publication


Featured researches published by Rogelio Menendez.


The Journal of Allergy and Clinical Immunology | 1982

Effects of theophylline on inhaled methacholine and histamine in asthmatic children

Bennie McWilliams; Rogelio Menendez; H.W. Kelley; J. Howick; B. Pharm.

The effects of a therapeutic serum theophylline concentration on inhaled methacholine and histamine were studied in 8 stable, moderately severe asthmatic children 8 to 15 yr of age. Placebo or theophylline in a hydroalcoholic solution was administered in a double-blind fashion, and standard histamine and methacholine challenges were performed following both placebo and theophylline. Serum theophylline concentration averaged 13 mg/L (range 4.0 to 22.1). Theophylline caused a significant increase (p less than 0.01, paired t test) in provocative dose for a 20% drop in FEV1 (PD20 FEV1) for both methacholine (from a mean of 19.1 to 57.5) and histamine (75.9 to 144.5). This effect did not correlate with the small (7.6% increase in FEV1) but significant bronchodilatation produced by theophylline. We conclude that theophylline in doses that achieve serum concentrations in the usual therapeutic range produces significant attenuation of the bronchoconstrictor response to methacholine and histamine challenges in asthmatic children. The mechanism and therapeutic implications of this remain undefined.


The Journal of Pediatrics | 1982

Pharmacokinetics of tobramycin in cystic fibrosis

H. Bill Kelly; D Pharm; Rogelio Menendez; Leland L. Fan; Shirley Murphy


JAMA Pediatrics | 1983

Sustained-Release Theophylline: Pharmacokinetic and Therapeutic Comparison of Two Preparations

Rogelio Menendez; H. William Kelly; Jaime Howick; Bennie McWilliams


Journal of Asthma | 1983

Role of Patient Compliance in the Management of Asthma

Joy B. Voyles; Rogelio Menendez


The Journal of Allergy and Clinical Immunology | 1983

167 Absorption characteristics of a new sustained-release theophylline (SRT) sprinkle for infants and young children

J. Howick; Hw Kelly; Rogelio Menendez; Shirley Murphy


The American review of respiratory disease | 1986

Comparison of the effects of intravenously administered aminophylline and inhaled isoproterenol on normal airways.

Bennie McWilliams; Rogelio Menendez; Kelly Hw; J. Howick


The American review of respiratory disease | 1982

Airway pharmacology of theophylline in asthmatic children

Bennie McWilliams; Rogelio Menendez; Kelly Hw; J. Howick


Annals of Pharmacotherapy | 1982

A multiple-dose, crossover comparison of two sustained-release theophylline tablets in asthmatic children

J. Howick; Kelly Hw; Rogelio Menendez; Bennie McWilliams

Collaboration


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Bennie McWilliams

University of Texas at Austin

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J. Howick

University of New Mexico

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Kelly Hw

University of New Mexico

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Shirley Murphy

University of New Mexico

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D Pharm

University of New Mexico

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H. Bill Kelly

University of New Mexico

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Jaime Howick

University of New Mexico

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Joy B. Voyles

University of New Mexico

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Leland L. Fan

Baylor College of Medicine

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