Rogelio Menendez
University of New Mexico
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Featured researches published by Rogelio Menendez.
The Journal of Allergy and Clinical Immunology | 1982
Bennie McWilliams; Rogelio Menendez; H.W. Kelley; J. Howick; B. Pharm.
The effects of a therapeutic serum theophylline concentration on inhaled methacholine and histamine were studied in 8 stable, moderately severe asthmatic children 8 to 15 yr of age. Placebo or theophylline in a hydroalcoholic solution was administered in a double-blind fashion, and standard histamine and methacholine challenges were performed following both placebo and theophylline. Serum theophylline concentration averaged 13 mg/L (range 4.0 to 22.1). Theophylline caused a significant increase (p less than 0.01, paired t test) in provocative dose for a 20% drop in FEV1 (PD20 FEV1) for both methacholine (from a mean of 19.1 to 57.5) and histamine (75.9 to 144.5). This effect did not correlate with the small (7.6% increase in FEV1) but significant bronchodilatation produced by theophylline. We conclude that theophylline in doses that achieve serum concentrations in the usual therapeutic range produces significant attenuation of the bronchoconstrictor response to methacholine and histamine challenges in asthmatic children. The mechanism and therapeutic implications of this remain undefined.
The Journal of Pediatrics | 1982
H. Bill Kelly; D Pharm; Rogelio Menendez; Leland L. Fan; Shirley Murphy
JAMA Pediatrics | 1983
Rogelio Menendez; H. William Kelly; Jaime Howick; Bennie McWilliams
Journal of Asthma | 1983
Joy B. Voyles; Rogelio Menendez
The Journal of Allergy and Clinical Immunology | 1983
J. Howick; Hw Kelly; Rogelio Menendez; Shirley Murphy
The American review of respiratory disease | 1986
Bennie McWilliams; Rogelio Menendez; Kelly Hw; J. Howick
The American review of respiratory disease | 1982
Bennie McWilliams; Rogelio Menendez; Kelly Hw; J. Howick
Annals of Pharmacotherapy | 1982
J. Howick; Kelly Hw; Rogelio Menendez; Bennie McWilliams