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Dive into the research topics where Roger R. Reddel is active.

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Featured researches published by Roger R. Reddel.


Archive | 1988

Cellular and Molecular Studies of Growth, Differentiation and Neoplastic Transformation of Human Bronchial Epithelial Cells in Vitro

Curtis C. Harris; Roger R. Reddel; Yang Ke; Andrea Pfeiffer; Mark G; Tohru Masui; George H. Yoakum; Brenda I. Gerwin; Paul Amstad; John F. Lechner

Normal human cells in vitro appear to retain many normal phenotypic properties, remain diploid, eventually undergo senescence and rarely, if ever “spontaneously” transform to malignant cells. Retained properties may include synthesis of classes of proteins associated with specific cell types such as collagens, keratins, or melanin; responsiveness to hormones; and antigenic specificity. In addition, human cells with abnormal phenotypes such as either enzymatic deficits or malignant properties frequently maintain these phenotype in vitro. Human cells cultured in vitro have thus proven to be extremely useful to scientists studying the molecular and biochemical aspects of human carcinogenesis. Such studies have been facilitated by the recent development of improved methods for culturing normal human epithelial tissues and cells1. Chemically defined media have been developed for culturing many of these tissues and cells from normal organs, including those with a high rate of cancer in humans. Serum-free media have several advantages in studies of cultured human cells, including: (a) less experimental variability compared to serum-containing media; (b) selective growth conditions for normal cells of different types (e.g. epithelial versus fibroblastic) or for normal versus malignant cells; (c) ease of identification of growth factors, inhibitors of growth, and inducers of differentiation; and (d) ease of isolating and analyzing secreted cellular products. Advances in cell biology, including the delineation of biochemical and morphological markers of specific cell types, have also facilitated the identification of cells in vitro (including keratins as markers for epithelial cells and collagen types I and III for identifying fibroblasts). These advances have created experimental approaches to answering critical questions in human cell carcinogenesis1,2.


Cancer Research | 1987

Comparison of Production of Transforming Growth Factor-β and Platelet-derived Growth Factor by Normal Human Mesothelial Cells and Mesothelioma Cell Lines

Brenda I. Gerwin; John F. Lechner; Roger R. Reddel; Anita B. Roberts; Keith C. Robbins; Edward W. Gabrielson; Curtis C. Harris


Archive | 1987

Immortalized human bronchial epitherial mesothelial cell lines

Roger R. Reddel; Ke Yang; Johng S. Rhim; Douglas E. Brash; Robert T. Su; John F. Lechner; Brenda I. Gerwin; Curtis C. Harris; Paul Amstad


Archive | 1992

Human liver epithelial cell line and culture media therefor

Katharine H. Cole; John F. Lechner; Roger R. Reddel; Curtis C. Harris; Andrea Pfeifer


Archive | 1991

Immortalized non-tumorigenic human bronchial epithelial cell lines

Roger R. Reddel; Yang Ke; Johng S. Rhim; Douglas E. Brash; Robert T. Su; John F. Lechner; Brenda I. Gerwin; Curtis C. Harris; Paul Amstad


Archive | 1990

Human esophageal epithelial cell lines

Gary D. Stoner; Roger R. Reddel; Curtis Craig Harris


Archive | 2011

Teolmerase activity in plueral malignant mesotheliomas

Amy Y.M. Au; Torben Hackl; Thomas R. Yeager; Scott B. Cohen; Harvey I. Pass; Curtis C. Harris; Roger R. Reddel


Archive | 1994

Human epithelial cell lines of liver

Katharine H. Cole; Curtis C. Harris; John F. Lechner; Roger R. Reddel


Archive | 1994

Humane epithelzellinien der leber Human epithelial cell of the liver

Katharine H. Cole; Curtis C. Harris; John F. Lechner; Roger R. Reddel


Archive | 1994

epithelial cell lines of human liver.

Katharine H. Cole; Curtis C. Harris; John F. Lechner; Roger R. Reddel

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John F. Lechner

National Institutes of Health

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Brenda I. Gerwin

National Institutes of Health

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Paul Amstad

National Institutes of Health

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Johng S. Rhim

National Institutes of Health

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Curtis C. Harris

National Institutes of Health

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Gary D. Stoner

Medical College of Wisconsin

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Yang Ke

National Institutes of Health

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Andrea Pfeiffer

National Institutes of Health

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Anita B. Roberts

National Institutes of Health

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