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Roland S. Rogers

G. D. Searle & Company

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Publication

Featured researches published by Roland S. Rogers.

Bioorganic & Medicinal Chemistry Letters | 1995

3,4-diarylthiophenes are selective COX-2 inhibitors

Stephen R. Bertenshaw; John J. Talley; Donald J. Rogier; Matthew J. Graneto; Roland S. Rogers; Steven W. Kramer; Thomas D. Penning; Carol M. Koboldt; Amy W. Veenhuizen; Yan Zhang; William E. Perkins

Abstract A group of 3,4-diarylthiophenes containing either a sulfone or sulfonamide moiety were synthesized and tested for COX-1 and COX-2 inhibition. They are selective inhibitors of COX-2 and possess antiinflammatory activity in vivo .

Journal of Medicinal Chemistry | 1997

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning; John J. Talley; Stephen R. Bertenshaw; Jeffery S. Carter; Paul W. Collins; Stephen H Docter; Matthew J. Graneto; Len F. Lee; James W. Malecha; Julie M. Miyashiro; Roland S. Rogers; Donald J. Rogier; Stella S. Yu; Gary D. Anderson; Earl G. Burton; J. Nita Cogburn; Susan A. Gregory; Carol M. Koboldt; William Perkins; Karen Seibert; Amy W. Veenhuizen; and Yan Y. Zhang; Peter C. Isakson

Archive | 1993

Substituted pyrazolyl benzenesulfonamides

John J. Talley; Thomas D. Penning; Paul W. Collins; Donald J. Rogier; James W. Malecha; Julie M. Miyashiro; Stephen R. Bertenshaw; Ish K. Khanna; Matthew J. Graneto; Roland S. Rogers; Jeffery S. Carter

Archive | 1996

Substituted isoxazoles for the treatment of inflammation

John J. Talley; David L. Brown; Srinivasan Nagarajan; Jeffery S. Carter; Richard M. Weier; Michael A. Stealey; Paul W. Collins; Roland S. Rogers; Karen Seibert

Archive | 1994

Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation

John J. Talley; Thomas D. Penning; Paul W. Collins; Donald J. Rogier; James W. Malecha; Julie M. Miyashiro; Stephen R. Bertenshaw; Ish K. Khanna; Matthew J. Graneto; Roland S. Rogers; Jeffery S. Carter; Stephen H Docter; Stella S. Yu

Archive | 1994

Novel 3,4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents

John J. Talley; Stephen R. Bertenshaw; Paul W. Collins; Thomas D. Penning; David B. Reitz; Roland S. Rogers

Archive | 1995

Substituted thiazoles for the treatment of inflammation

John J. Talley; Jeffery S. Carter; Paul W. Collins; Steven W. Kramer; Thomas D. Penning; Donald J. Rogier; Roland S. Rogers

Archive | 1996

Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors

John J. Talley; James A. Sikorski; Bryan H. Norman; Roland S. Rogers; Balekudru Devadas; Matthew J. Graneto; Jeffery S. Carter

Archive | 1995

Substituted pyrazolyl benzenesulfonamide compounds for the treatment of inflammation

John J. Talley; Thomas D. Penning; Paul W. Collins; Donald J. Rogier; James W. Malecha; Julie M. Miyashiro; Stephen R. Bertenshaw; Ish K. Khanna; Matthew J. Graneto; Roland S. Rogers; Jeffery S. Carter

Archive | 1997

Substituted isoxazole for the treatment of inflammation

John J. Talley; Srinivasan Nagarajan; Roland S. Rogers

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Collaboration

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Donald J. Rogier

G. D. Searle

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Carol M. Koboldt

G. D. Searle

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Gary D. Anderson

Columbia University

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Karen Seibert

G. D. Searle

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Peter C. Isakson

University of Virginia

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Susan A. Gregory

Columbia University

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William Perkins

University of Nottingham

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