Roland Schüle
University of Erlangen-Nuremberg
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Publication
Featured researches published by Roland Schüle.
Journal of Biological Chemistry | 2004
Thomas Samson; Neil Smyth; Stefanie Janetzky; Olaf Wendler; Judith M. Müller; Roland Schüle; Helga von der Mark; Klaus von der Mark; Viktor Wixler
FHL1, FHL2, and FHL3 are members of the four and one-half LIM domain protein subclass that are expressed in striated muscles. Here we show that FHL2 and FHL3 are novel α7β1 integrin-interacting proteins. They bind both the α- and the β-subunit as well as different splice isoforms. The minimal binding sites for FHL2 and FHL3 on β1A-chain overlap, whereas on α7A and α7B subunits they are situated adjacent. Determining the binding sites for integrins on FHL2 or FHL3 revealed that the suprastructure of the whole molecule is important for these associations, rather than any single LIM domain. Immunofluorescence studies with cells expressing full-length FHL proteins or their deletion mutants showed that FHL2 and FHL3 but not FHL1 colocalize with integrins at cell adhesion sites. Further, their recruitment to the membrane results from binding to either the α- or the β-chain of the integrin receptor. The association of FHL2 or FHL3 with integrin receptors neither influences attachment of cells to different substrates nor changes their migration capacity. However, in cardiac and skeletal muscles, FHL2 and FHL3, respectively, are colocalized with α7β1 integrin receptor at the periphery of Z-discs, suggesting a role in mechanical stabilization of muscle cells.
Archive | 2010
Roland Schüle; Eric Metzger; Reinhard Büttner; Jutta Kirfel
Archive | 2010
Manfred Jung; Roland Schüle; Eric Metzger; Jürgen Liebscher; Michael Pätzel; Wolfgang Sippl
Archive | 2004
Roland Schüle; Thomas Günther; Judith Dr. Müller
Archive | 2010
Roland Schüle; Thomas Günther; Eric Metzger
Archive | 2011
Roland Schüle; Eric Metzger
Archive | 2015
Roland Schüle; Delphine Duteil; Eric Metzger; Thomas Günther
Archive | 2014
Andrew B. Leiter; Subir K. Ray; H. Joyce Li; Eric Metzger; Roland Schüle
Archive | 2013
Roland Schüle; Delphine Duteil; Eric Metzger; Thomas Günther
Archive | 2010
Eric Metzger; Roland Schüle