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Dive into the research topics where Roland Solensky is active.

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Featured researches published by Roland Solensky.


The Journal of Allergy and Clinical Immunology | 2014

Penicillin allergy as a public health measure.

Roland Solensky

Penicillin allergy is self-reported by approximately 10% of the population. Therefore physicians are often faced with having to choose antibiotic therapy for patients with a history of penicillin allergy. When surveyed physicians are presented theoretic scenarios of antibiotic treatment in patients with a history of penicillin allergy, it is not surprising that they frequently choose non–b-lactam antibiotics, such as quinolones, vancomycin, and macrolides. Studies of prescribing patterns in both hospital and clinic settings have shown that patients labeled as having ‘‘penicillin allergy’’ are more likely to be treated with broadspectrum antibiotics, such as quinolones, vancomycin, and third-generation cephalosporins. At a university hospital, Lee et al retrospectively analyzed computerized records and found that among inpatients with a history of penicillin allergy, 39.7% received vancomycin and 21.5% received levofloxacin compared with 17.4% and 8.0% of patients without any antibiotic allergies, respectively (P < .001 for each data pair). Similarly, at a university-based clinic, retrospective medical record review of patients whowere prescribed antibiotics for either an upper respiratory tract infection or urinary tract infection revealed that those with a b-lactam allergy were more likely to have received cephalosporins, macrolides, quinolones, tetracyclines, or nitrofurantoin (P 5 .001 for all antibiotics). Hospitals commonly restrict use of vancomycin to specific indications, one of which is ‘‘penicillin allergy.’’ Review of pharmacy records has shown that in 31% to 51% of all vancomycin prescriptions, the drug was prescribed instead of another antibiotic solely because of a recorded ‘‘penicillin allergy.’’ Use of broad-spectrum antibiotics is associated with various clinical complications, such as antibiotic resistance and Clostridium difficile. Using a retrospective case-control design, Martinez et al evaluated risk factors for acquisition of vancomycin-resistant enterococcus (VRE) in patients admitted to a medical intensive care unit, comparing them with matched control subjects. They found that during the previous month, patients with VRE were significantly more likely to have been treated with vancomycin (odds ratio, 5.1; P 5 .02), cephalosporins (mostly third generation; odds ratio, 6.0; P 5 .03), and


Annals of Allergy Asthma & Immunology | 2003

Resolution of fish allergy: a case report

Roland Solensky

BACKGROUND Fish allergy is one of the most common food allergies, and it is believed to be lifelong. There are no published reports, to my knowledge, of resolution of fish allergy. OBJECTIVE To report a case of resolution of IgE-mediated fish allergy. METHODS The patient was a 68-year-old man with a history of fish-induced anaphylaxis who had previously undergone prick-puncture skin testing to several fish species. Additional skin testing was performed in October 2002. Subsequently, he underwent an open challenge with halibut. RESULTS The patients previous skin tests showed him to have strongly positive reactions to several fish species. However, testing performed in October 2002 produced negative results to a number of fish species. In addition, he tolerated an open challenge with halibut. In the ensuing 8 months, he has regularly ingested salmon, cod, and halibut without experiencing any allergic reactions. CONCLUSIONS This case illustrates that fish allergy is not invariably lifelong. Hence, allergists should consider reevaluating the allergy status of adults with a history of fish hypersensitivity.


Current Allergy and Asthma Reports | 2014

Evaluation of Antibiotic Allergy: the Role of Skin Tests and Drug Challenges

Roland Solensky; David A. Khan

Antibiotic allergies are frequently reported in both adult and pediatric populations. While a detailed drug history is essential in the evaluation of antibiotic allergy, the history is typically insufficient to determine the presence of a drug allergy. The most readily available diagnostic testing for evaluating antibiotic allergies are drug skin testing and drug challenges. This review will focus on updates in the evaluation of antibiotic allergy utilizing immediate skin tests, delayed intradermal testing, drug patch tests, and drug challenges for both adults and children with histories of antibiotic allergies.


The Journal of Allergy and Clinical Immunology | 2005

The diagnosis and management of anaphylaxis: An updated practice parameter

Phillip Lieberman; Stephen F. Kemp; John Oppenheimer; David M. Lang; I. Leonard Bernstein; Richard A. Nicklas; John A. Anderson; David I. Bernstein; Jonathan A. Bernstein; Jordan N. Fink; Paul A. Greenberger; Dennis K. Ledford; James T. Li; Albert L. Sheffer; Roland Solensky; Bruce L. Wolf; Joann Blessing-Moore; David A. Khan; Rufus E. Lee; Jay M. Portnoy; Diane E. Schuller; Sheldon L. Spector; Stephen A. Tilles


JAMA Internal Medicine | 2002

Lack of penicillin resensitization in patients with a history of penicillin allergy after receiving repeated penicillin courses

Roland Solensky; Harry S Earl; Rebecca S. Gruchalla


Annals of Allergy Asthma & Immunology | 2000

Penicillin allergy: prevalence of vague history in skin test-positive patients

Roland Solensky; Harry S Earl; Rebecca S. Gruchalla


Annals of Allergy Asthma & Immunology | 2000

Clinical approach to penicillin-allergic patients: a survey

Roland Solensky; Harry S Earl; Rebecca S. Gruchalla


The Journal of Allergy and Clinical Immunology | 2002

Safety of cephalosporin administration to patients with histories of penicillin allergy

Sonak Daulat; Roland Solensky; Harry S Earl; William Casey; Rebecca S. Gruchalla


The Journal of Allergy and Clinical Immunology | 2012

Allergy to β-lactam antibiotics

Roland Solensky


The Journal of Allergy and Clinical Immunology: In Practice | 2015

Minor Determinants Are Essential for Optimal Penicillin Allergy Testing: A Pro/Con Debate.

Roland Solensky; Eric Macy

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Rebecca S. Gruchalla

University of Texas Southwestern Medical Center

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Harry S Earl

University of Texas Southwestern Medical Center

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David A. Khan

University of Texas Southwestern Medical Center

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A. Romano

The Catholic University of America

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Albert L. Sheffer

Brigham and Women's Hospital

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Dennis K. Ledford

University of South Florida

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