Roland Wenger
École Polytechnique Fédérale de Lausanne
Tetrahedron | 2003
Luc Patiny; Jean-François Guichou; Michael Keller; Olivier Turpin; Thomas Rückle; Philippe Lhote; Timo M. Buetler; Urs T. Ruegg; Roland Wenger; Manfred Mutter
The chemical synthesis, conformational analysis and receptor binding studies of novel constrained cyclosporin A (CsA) analogues are described. The selective insertion of pseudo-proline (PsiPro) systems featuring different 2-C-substituents at the oxazolidine ring exerts dramatic effects upon the backbone conformation as demonstrated by NMR analysis. It is shown that the insertion of a Psi(MeMe)pro at position 5 (Thr(5)CsA) maintains binding to cyclophilin A as well as to calcineurin and shows a 5-6 cis amide bond with all remaining amide bonds trans. The elaborated synthetic routes for generating PsiPro containing Cs derivatives pave the way for extended structure-activity relationship studies aiming at the design of potential pharmacologically active compounds with a selective activity profile
Journal of Peptide Research | 2008
A.R. Hamel; F. Hubler; A. Carrupt; Roland Wenger; Manfred Mutter
Archive | 2000
Manfred Mutter; Roland Wenger; Jean-François Guichou; Michael Keller; Thomas Ruckle; Torsten Woehr
Archive | 2002
Roland Wenger; Manfred Mutter; Arnaud Hamel; Francis Hubler
Archive | 2009
Roland Wenger; Manfred Mutter; Patrick Garrouste; Robert Lysek; Olivier Turpin; Grégoire Vuagniaux; Valérie Nicolas; Laura Novaroli Zanolari; Rafael Crabbé
Archive | 2002
Roland Wenger; Manfred Mutter; Arnaud Hamel; Francis Hubler
Archive | 2002
Roland Wenger; Manfred Mutter; Amaud Hamel; Francis Hubler
Archive | 2009
Roland Wenger; Manfred Mutter; Patrick Garrouste; Robert Lysek; Olivier Turpin; Grégoire Vuagniaux; Valérie Nicolas; Zanolari Laura Novaroli; Rafael Crabbé
Archive | 2002
Roland Wenger; Manfred Mutter; Arnaud Hamel; Francis Hubler
Archive | 2002
Arnaud Hamel; Francis Hubler; Manfred Mutter; Roland Wenger
