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Featured researches published by Roman Kosoy.


The New England Journal of Medicine | 2008

Association of Systemic Lupus Erythematosus with C8orf13–BLK and ITGAM–ITGAX

Geoffrey Hom; Robert R. Graham; Barmak Modrek; Kimberly E. Taylor; Ward Ortmann; Sophie Garnier; Annette Lee; Sharon A. Chung; Ricardo C. Ferreira; P.V. Krishna Pant; Dennis G. Ballinger; Roman Kosoy; F. Yesim Demirci; M. Ilyas Kamboh; Amy H. Kao; Chao Tian; Iva Gunnarsson; Anders Bengtsson; Solbritt Rantapää-Dahlqvist; Michelle Petri; Susan Manzi; Michael F. Seldin; Lars Rönnblom; Ann-Christine Syvänen; Lindsey A. Criswell; Peter K. Gregersen; Timothy W. Behrens

BACKGROUND Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease in which the risk of disease is influenced by complex genetic and environmental contributions. Alleles of HLA-DRB1, IRF5, and STAT4 are established susceptibility genes; there is strong evidence for the existence of additional risk loci. METHODS We genotyped more than 500,000 single-nucleotide polymorphisms (SNPs) in DNA samples from 1311 case subjects with SLE and 1783 control subjects; all subjects were North Americans of European descent. Genotypes from 1557 additional control subjects were obtained from public data repositories. We measured the association between the SNPs and SLE after applying strict quality-control filters to reduce technical artifacts and to correct for the presence of population stratification. Replication of the top loci was performed in 793 case subjects and 857 control subjects from Sweden. RESULTS Genetic variation in the region upstream from the transcription initiation site of the gene encoding B lymphoid tyrosine kinase (BLK) and C8orf13 (chromosome 8p23.1) was associated with disease risk in both the U.S. and Swedish case-control series (rs13277113; odds ratio, 1.39; P=1x10(-10)) and also with altered levels of messenger RNA in B-cell lines. In addition, variants on chromosome 16p11.22, near the genes encoding integrin alpha M (ITGAM, or CD11b) and integrin alpha X (ITGAX), were associated with SLE in the combined sample (rs11574637; odds ratio, 1.33; P=3x10(-11)). CONCLUSIONS We identified and then confirmed through replication two new genetic loci for SLE: a promoter-region allele associated with reduced expression of BLK and increased expression of C8orf13 and variants in the ITGAM-ITGAX region.


Nature Genetics | 2009

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

Vesela Gateva; Johanna K. Sandling; Geoff Hom; Kimberly E. Taylor; Sharon A. Chung; Xin Sun; Ward Ortmann; Roman Kosoy; Ricardo C. Ferreira; Gunnel Nordmark; Iva Gunnarsson; Elisabet Svenungsson; Leonid Padyukov; Gunnar Sturfelt; Andreas Jönsen; Anders Bengtsson; Solbritt Rantapää-Dahlqvist; Emily C. Baechler; Elizabeth E. Brown; Graciela S. Alarcón; Jeffrey C. Edberg; Rosalind Ramsey-Goldman; Gerald McGwin; John D. Reveille; Luis M. Vilá; Robert P. Kimberly; Susan Manzi; Michelle Petri; Annette Lee; Peter K. Gregersen

Genome-wide association studies have recently identified at least 15 susceptibility loci for systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from 2,466 regions that showed nominal evidence of association to SLE (P < 0.05) in a genome-wide study and genotyped them in an independent sample of 1,963 cases and 4,329 controls. This replication effort identified five new SLE susceptibility loci (P < 5 × 10−8): TNIP1 (odds ratio (OR) = 1.27), PRDM1 (OR = 1.20), JAZF1 (OR = 1.20), UHRF1BP1 (OR = 1.17) and IL10 (OR = 1.19). We identified 21 additional candidate loci with P≤ 1 × 10−5. A candidate screen of alleles previously associated with other autoimmune diseases suggested five loci (P < 1 × 10−3) that may contribute to SLE: IFIH1, CFB, CLEC16A, IL12B and SH2B3. These results expand the number of confirmed and candidate SLE susceptibility loci and implicate several key immunologic pathways in SLE pathogenesis.


Human Mutation | 2009

Ancestry Informative Marker Sets for Determining Continental Origin and Admixture Proportions in Common Populations in America

Roman Kosoy; Rami Nassir; Chao Tian; Phoebe A. White; Lesley M. Butler; Gabriel Silva; Rick A. Kittles; Marta E. Alarcón-Riquelme; Peter K. Gregersen; John W. Belmont; Francisco M. De La Vega; Michael F. Seldin

To provide a resource for assessing continental ancestry in a wide variety of genetic studies, we identified, validated, and characterized a set of 128 ancestry informative markers (AIMs). The markers were chosen for informativeness, genome‐wide distribution, and genotype reproducibility on two platforms (TaqMan® assays and Illumina arrays). We analyzed genotyping data from 825 subjects with diverse ancestry, including European, East Asian, Amerindian, African, South Asian, Mexican, and Puerto Rican. A comprehensive set of 128 AIMs and subsets as small as 24 AIMs are shown to be useful tools for ascertaining the origin of subjects from particular continents, and to correct for population stratification in admixed population sample sets. Our findings provide general guidelines for the application of specific AIM subsets as a resource for wide application. We conclude that investigators can use TaqMan assays for the selected AIMs as a simple and cost efficient tool to control for differences in continental ancestry when conducting association studies in ethnically diverse populations. Hum Mutat 0,1–10, 2008.


Nature Genetics | 2010

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

Xiangdong Liu; Pietro Invernizzi; Yue Lu; Roman Kosoy; Yan Lu; Ilaria Bianchi; Mauro Podda; Chun Xu; Gang Xie; Fabio Macciardi; Carlo Selmi; Sara Lupoli; Russell Shigeta; Michael Ransom; Ana Lleo; Annette Lee; Andrew L. Mason; Robert P. Myers; Kevork M. Peltekian; Cameron N. Ghent; Francesca Bernuzzi; Massimo Zuin; Floriano Rosina; Elisabetta Borghesio; Annarosa Floreani; Roberta Delasta Lazzari; G. Niro; Angelo Andriulli; Luigi Muratori; Paolo Muratori

A genome-wide association screen for primary biliary cirrhosis risk alleles was performed in an Italian cohort. The results from the Italian cohort replicated IL12A and IL12RB associations, and a combined meta-analysis using a Canadian dataset identified newly associated loci at SPIB (P = 7.9 × 10−11, odds ratio (OR) = 1.46), IRF5-TNPO3 (P = 2.8 × 10−10, OR = 1.63) and 17q12-21 (P = 1.7 × 10−10, OR = 1.38).


Human Molecular Genetics | 2011

Genome-wide association study identifies novel loci predisposing to cutaneous melanoma

Christopher I. Amos; Li-E Wang; Jeffrey E. Lee; Jeffrey E. Gershenwald; Wei Chen; Shenying Fang; Roman Kosoy; Mingfeng Zhang; Abrar A. Qureshi; Selina Vattathil; Christopher W. Schacherer; Julie M. Gardner; Yuling Wang; D. Tim Bishop; Jennifer H. Barrett; Stuart Macgregor; Nicholas K. Hayward; Nicholas G. Martin; David L. Duffy; Graham J. Mann; Anne E. Cust; John L. Hopper; Kevin M. Brown; Elizabeth A. Grimm; Yaji Xu; Younghun Han; Kaiyan Jing; Caitlin P. McHugh; Cathy C. Laurie; Kim Doheny

We performed a multistage genome-wide association study of melanoma. In a discovery cohort of 1804 melanoma cases and 1026 controls, we identified loci at chromosomes 15q13.1 (HERC2/OCA2 region) and 16q24.3 (MC1R) regions that reached genome-wide significance within this study and also found strong evidence for genetic effects on susceptibility to melanoma from markers on chromosome 9p21.3 in the p16/ARF region and on chromosome 1q21.3 (ARNT/LASS2/ANXA9 region). The most significant single-nucleotide polymorphisms (SNPs) in the 15q13.1 locus (rs1129038 and rs12913832) lie within a genomic region that has profound effects on eye and skin color; notably, 50% of variability in eye color is associated with variation in the SNP rs12913832. Because eye and skin colors vary across European populations, we further evaluated the associations of the significant SNPs after carefully adjusting for European substructure. We also evaluated the top 10 most significant SNPs by using data from three other genome-wide scans. Additional in silico data provided replication of the findings from the most significant region on chromosome 1q21.3 rs7412746 (P = 6 × 10(-10)). Together, these data identified several candidate genes for additional studies to identify causal variants predisposing to increased risk for developing melanoma.


BMC Genetics | 2009

An ancestry informative marker set for determining continental origin: validation and extension using human genome diversity panels

Rami Nassir; Roman Kosoy; Chao Tian; Phoebe A. White; Lesley M. Butler; Gabriel Silva; Rick A. Kittles; Marta E. Alarcón-Riquelme; Peter K. Gregersen; John W. Belmont; Francisco M. De La Vega; Michael F. Seldin

BackgroundCase-control genetic studies of complex human diseases can be confounded by population stratification. This issue can be addressed using panels of ancestry informative markers (AIMs) that can provide substantial population substructure information. Previously, we described a panel of 128 SNP AIMs that were designed as a tool for ascertaining the origins of subjects from Europe, Sub-Saharan Africa, Americas, and East Asia.ResultsIn this study, genotypes from Human Genome Diversity Panel populations were used to further evaluate a 93 SNP AIM panel, a subset of the 128 AIMS set, for distinguishing continental origins. Using both model-based and relatively model-independent methods, we here confirm the ability of this AIM set to distinguish diverse population groups that were not previously evaluated. This study included multiple population groups from Oceana, South Asia, East Asia, Sub-Saharan Africa, North and South America, and Europe. In addition, the 93 AIM set provides population substructure information that can, for example, distinguish Arab and Ashkenazi from Northern European population groups and Pygmy from other Sub-Saharan African population groups.ConclusionThese data provide additional support for using the 93 AIM set to efficiently identify continental subject groups for genetic studies, to identify study population outliers, and to control for admixture in association studies.


Annals of Neurology | 2012

Risk for Myasthenia Gravis Maps to a (151)Pro -> Ala Change in TNIP1 and to Human Leukocyte Antigen-B*08

Peter K. Gregersen; Roman Kosoy; Annette Lee; Janine A. Lamb; Jon Sussman; David McKee; Kim R. Simpfendorfer; Ritva Pirskanen-Matell; Frederik Piehl; Qiang Pan-Hammarström; Jan J. Verschuuren; Maarten J. Titulaer; Erik H. Niks; Alexander Marx; Philipp Ströbel; Björn Tackenberg; Michael Pütz; Angelina Maniaol; Ahmed Elsais; Chantal Tallaksen; Hanne F. Harbo; Benedicte A. Lie; Soumya Raychaudhuri; Paul I. W. de Bakker; Arthur Melms; Henri Jean Garchon; Nicholas Willcox; Lennart Hammarström; Michael F. Seldin

The objective of this study is to comprehensively define the genetic basis of early onset myasthenia gravis (EOMG).


PLOS ONE | 2008

Analysis of East Asia Genetic Substructure Using Genome-Wide SNP Arrays

Chao-wei Tian; Roman Kosoy; Annette Lee; Michael Ransom; John W. Belmont; Peter K. Gregersen; Michael F. Seldin

Accounting for population genetic substructure is important in reducing type 1 errors in genetic studies of complex disease. As efforts to understand complex genetic disease are expanded to different continental populations the understanding of genetic substructure within these continents will be useful in design and execution of association tests. In this study, population differentiation (Fst) and Principal Components Analyses (PCA) are examined using >200 K genotypes from multiple populations of East Asian ancestry. The population groups included those from the Human Genome Diversity Panel [Cambodian, Yi, Daur, Mongolian, Lahu, Dai, Hezhen, Miaozu, Naxi, Oroqen, She, Tu, Tujia, Naxi, Xibo, and Yakut], HapMap [ Han Chinese (CHB) and Japanese (JPT)], and East Asian or East Asian American subjects of Vietnamese, Korean, Filipino and Chinese ancestry. Paired Fst (Wei and Cockerham) showed close relationships between CHB and several large East Asian population groups (CHB/Korean, 0.0019; CHB/JPT, 00651; CHB/Vietnamese, 0.0065) with larger separation with Filipino (CHB/Filipino, 0.014). Low levels of differentiation were also observed between Dai and Vietnamese (0.0045) and between Vietnamese and Cambodian (0.0062). Similarly, small Fsts were observed among different presumed Han Chinese populations originating in different regions of mainland of China and Taiwan (Fsts <0.0025 with CHB). For PCA, the first two PCs showed a pattern of relationships that closely followed the geographic distribution of the different East Asian populations. PCA showed substructure both between different East Asian groups and within the Han Chinese population. These studies have also identified a subset of East Asian substructure ancestry informative markers (EASTASAIMS) that may be useful for future complex genetic disease association studies in reducing type 1 errors and in identifying homogeneous groups that may increase the power of such studies.


Human Molecular Genetics | 2012

Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants

Brian D. Juran; Gideon M. Hirschfield; Pietro Invernizzi; Elizabeth J. Atkinson; Yafang Li; Gang Xie; Roman Kosoy; Michael Ransom; Ye Sun; Ilaria Bianchi; Erik M. Schlicht; Ana Lleo; Catalina Coltescu; Francesca Bernuzzi; Mauro Podda; Craig Lammert; Russell Shigeta; Landon L. Chan; Tobias Balschun; Maurizio Marconi; Daniele Cusi; E. Jenny Heathcote; Andrew L. Mason; Robert P. Myers; Piotr Milkiewicz; Joseph A. Odin; Velimir A. Luketic; Bruce R. Bacon; Henry C. Bodenheimer; Valentina Liakina

To further characterize the genetic basis of primary biliary cirrhosis (PBC), we genotyped 2426 PBC patients and 5731 unaffected controls from three independent cohorts using a single nucleotide polymorphism (SNP) array (Immunochip) enriched for autoimmune disease risk loci. Meta-analysis of the genotype data sets identified a novel disease-associated locus near the TNFSF11 gene at 13q14, provided evidence for association at six additional immune-related loci not previously implicated in PBC and confirmed associations at 19 of 22 established risk loci. Results of conditional analyses also provided evidence for multiple independent association signals at four risk loci, with haplotype analyses suggesting independent SNP effects at the 2q32 and 16p13 loci, but complex haplotype driven effects at the 3q25 and 6p21 loci. By imputing classical HLA alleles from this data set, four class II alleles independently contributing to the association signal from this region were identified. Imputation of genotypes at the non-HLA loci also provided additional associations, but none with stronger effects than the genotyped variants. An epistatic interaction between the IL12RB2 risk locus at 1p31and the IRF5 risk locus at 7q32 was also identified and suggests a complementary effect of these loci in predisposing to disease. These data expand the repertoire of genes with potential roles in PBC pathogenesis that need to be explored by follow-up biological studies.


Molecular Medicine | 2009

European Population Genetic Substructure: Further Definition of Ancestry Informative Markers for Distinguishing among Diverse European Ethnic Groups

Chao Tian; Roman Kosoy; Rami Nassir; Annette Lee; Pablo Villoslada; Lars Klareskog; Lennart Hammarström; Henri Jean Garchon; Ann E. Pulver; Michael Ransom; Peter K. Gregersen; Michael F. Seldin

The definition of European population genetic substructure and its application to understanding complex phenotypes is becoming increasingly important. In the current study using over 4,000 subjects genotyped for 300,000 single-nucleotide polymorphisms (SNPs), we provide further insight into relationships among European population groups and identify sets of SNP ancestry informative markers (AIMs) for application in genetic studies. In general, the graphical description of these principal components analyses (PCA) of diverse European subjects showed a strong correspondence to the geographical relationships of specific countries or regions of origin. Clearer separation of different ethnic and regional populations was observed when northern and southern European groups were considered separately and the PCA results were influenced by the inclusion or exclusion of different self-identified population groups including Ashkenazi Jewish, Sardinian, and Orcadian ethnic groups. SNP AIM sets were identified that could distinguish the regional and ethnic population groups. Moreover, the studies demonstrated that most allele frequency differences between different European groups could be controlled effectively in analyses using these AIM sets. The European substructure AIMs should be widely applicable to ongoing studies to confirm and delineate specific disease susceptibility candidate regions without the necessity of performing additional genome-wide SNP studies in additional subject sets.

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Peter K. Gregersen

The Feinstein Institute for Medical Research

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Annette Lee

The Feinstein Institute for Medical Research

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Rami Nassir

University of California

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Michael Ransom

University of California

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Chao Tian

University of California

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John Robbins

University of California

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Lihong Qi

University of California

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Lorena Garcia

University of California

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