Ronald C. Hansen

Retinoblastoma in a Patient with a 13qxp Translocation

An infant girl with failure to thrive and bilateral retinoblastoma had a translocation of the long arm of chromosome 13 to the short arm of the X chromosome, and possible loss of a portion of the q 14 band. The lack of other major organ malformations in this patient emphasized the importance of considering chromosomal aberrations as a possible etiology of retinoblastoma in patients with nonspecific psychomotor retardation.

Diffuse neonatal hemangiomatosis with severe gastrointestinal involvement: favorable response to steroid therapy

Correspondence to: Alfred E. Stillman, M.D., Medical Arts Building-Suite 203, Harrington Memorial Hospital, Southbridge, MA 01550. Received for publication October 1982, revised December 1982 and accepted January 1983. DIFFUSE NEONATAL HEMANGIOMATOSIS (DNH) is a rare condition in which cutaneous and visceral hemangiomas coexist. Visceral hemangiomas may involve any organ, although the liver, central nervous system, and gastrointestinal tract are

Ciprofloxacin-induced granulomatous interstitial nephritis and localized elastolysis

Ciprofloxacin is known to cause acute interstitial nephritis. We report the first case of ciprofloxacin-induced granulomatous interstitial nephritis and localized elastolysis. The patient presented with acute renal failure and skin lesions following a 14-day course of ciprofloxacin administered for cellulitis. The patient had symmetric, palm-sized, tender violaceous plaques on both axillae. The renal biopsy revealed granulomatous interstitial disease. A skin biopsy revealed an elastolytic process with histocytic infiltration and calcification. After discontinuing ciprofloxacin and starting a short course of steroid therapy, the skin lesion and renal function improved promptly. The nephritis relapsed after prednisone was discontinued and responded to a second course of steroid therapy. Ciprofloxacin, like penicillin, can cause granulomatous interstitial nephritis and elastolysis. A prolonged course of steroid therapy may be indicated in patients with ciprofloxacin-induced granulomatous interstitial nephritis to avoid early relapse.

Staphylococcal scalded skin syndrome, toxic shock syndrome, and Kawasaki disease

Three dramatic clinical syndromes have been compared and contrasted. Of these, staphylococcal scalded syndrome is most readily recognized and least likely to have a morbid or fatal outcome. It is easy to confuse toxic shock syndrome and Kawasaki disease. Since the case fatality rate is significant in both of these diseases, and the management so different, proper recognition of the disease by its external features is critical.

Postoperative (pressure) alopecia

Postoperative localized alopecia has been reported most commonly after certain gynecologic and open heart surgery procedures, the likelihood of hair loss and the chance of permanence correlating with the length of the anesthesia and the intubation. Some cases of pressure-induced alopecia have been described after prolonged coma from other causes. Coma blisters have been reported after drug overdoses, but clinically similar blisters (not tested by biopsy) have been seen in other cases of coma. We present three cases of postoperative (pressure) alopecia and propose that both coma blisters and postoperative alopecia arise from the same phenomenon--probably pressure-induced ischemia.

Congenital Cutaneous Candidiasis: Case Report and Review

Abstract: This report describes a preterm infant with congenital cutaneous candidiasis associated with paronychia, dystrophy of the nail plates, and marked, transient leukocytosis.

Atypical Pityriasis Rubra Pilaris Associated with Arthropathy and Osteoporosis: A Case Report with 15‐Year Follow‐Up

Pityriasis rubra pilaris (PRP) is an idiopathic papulosquamous disease that clinically presents with palmoplantar keratoderma and follicular hyperkeratotic papules that coalesce into scaly erythematous plaques. We report a unique case of atypical PRP beginning at 1 year of age with associated severe arthropathy and osteoporosis. We further discuss the clinical and histopathologic aspects of PRP, its possible etiology, and other associated conditions.

Toddler-age nodulocystic acne.

Toddler-age nodulocystic acne is a rare disorder for which the etiology remains unknown. We report 2 cases and discuss the safety and efficacy of oral isotretinoin therapy. Oral isotretinoin is safe and effective in treating this condition but requires close monitoring.

Schamberg's Purpura in Children: Case Study and Literature Review

Schambergs purpura or progressive pigmentary dermatosis is uncommon in pediatric patients. A case study and literature review are presented to encourage the inclusion of Schambergs purpura in the differential diagnosis of purpuric eruptions in childhood.

The blue-gray cystic basal cell epithelioma

We report, in two men, the occurrence of a tiny, dome-shaped, blue-gray cystic nodule of the face. The nodule in both men clinically simulated an eccrine or apocrine hidrocystoma. Histologic examination revealed that both were cystic basal cell epitheliomas. These cases are reported in order to bring this unusual clinical presentation of basal cell epithelioma to the attention of clinicians.