Ronald E. Gress
Cleveland Clinic
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Featured researches published by Ronald E. Gress.
Journal of Clinical Oncology | 2008
Robert Dean; Terry J. Fry; Crystal L. Mackall; Seth M. Steinberg; Fran Hakim; Daniel H. Fowler; Jeanne Odom; Jason Foley; Ronald E. Gress; Michael R. Bishop
PURPOSEnMorbidity from acute graft-versus-host disease (GVHD) limits the success of allogeneic hematopoietic stem-cell transplantation (HSCT) to treat malignancy. Interleukin-7 (IL-7), the principal homeostatic cytokine for T cells, is required for acute GVHD in murine models. In contrast to inflammatory cytokines (eg, IL-2, tumor necrosis factor alpha), IL-7 has not been studied extensively in the clinical transplant setting relative to its relationship with acute GVHD.nnnPATIENTS AND METHODSnWe evaluated the association of serum IL-7 levels with acute GVHD in 31 patients who were uniformly treated in a prospective clinical trial with reduced-intensity allogeneic HSCT from human leukocyte antigen-identical siblings. GVHD prophylaxis consisted of cyclosporine and methotrexate. Serum IL-7 levels and lymphocyte populations were determined at enrollment, the day of transplantation before the allograft infusion, and at specified intervals through 12 months post-transplantation.nnnRESULTSnAs expected, IL-7 levels were inversely correlated with T-cell populations (P < .00001). Acute GVHD was significantly associated with higher IL-7 levels at day +7 (P = .01) and day +14 (P = .00003) post-transplantation as well as with the allograft CD34(+) cell dose (P = .01). IL-7 levels at day +14 also correlated with the severity of acute GVHD (P < .0001). In logistic regression models, these factors were highly sensitive (up to 86%) and specific (100%) for classifying whether patients developed acute GVHD.nnnCONCLUSIONnThese data support preclinical observations that IL-7 plays a critical role in inducing acute GVHD and provide a rational basis for novel approaches to prevent and treat acute GVHD through modulation of the IL-7 pathway.
Bone Marrow Transplantation | 2009
Crystal L. Mackall; Terry J. Fry; Ronald E. Gress; Karl S. Peggs; J Storek; A Toubert
Background to hematopoietic cell transplantation, including post transplant immune recovery
Journal of Clinical Oncology | 2004
Michael Boyiadzis; J. M. Carson; S. A. Memon; Robert Dean; Steven Z. Pavletic; Claude Kasten-Sportes; Daniel H. Fowler; Michael R. Bishop; Ronald E. Gress; Frances T. Hakim
6635 Background: Following hematopoietic stem cell transplantation (HSCT), natural killer (NK) cells are among the first lymphocytes to recover, returning to normal levels within six weeks after HSCT. NK cells may mediate anti-tumor effects and regulate graft versus host disease (GVHD); modulation of the relative frequency and intensity of expression of the cytotoxic NK receptors may influence NK activity post transplant.nnnMETHODSnWe compared the NK receptor expression in seven patients at one month following non-myeloablative HLA-matched allogeneic HSCT with that of donors and healthy volunteers. NK cells were divided into two subsets based on expression of CD56 and CD16. Both subsets were assessed for three main classes of receptors that trigger or inhibit cytotoxicity: natural cytotoxicity receptors (NCR), killer immunoglobulin-like receptors (KIR) and C-type lectin receptors.nnnRESULTSnCompared to donors, the expression of the NCR NKp46 increased significantly in all patients, whereas NKp30 increased in the CD 56+ bright subset only in patients that developed acute GVHD. Expression of KIR receptors (CD158A, CD158B) did not change or decreased slightly. In contrast the C-type lectin receptor CD 94 was upregulated on most NK cells. The heterodimeric partners of CD94, NKG2A and NKG2C, were also increased, but the increase in frequency of cells expressing the inhibitory receptor NKG2A was greater than that of the activating receptor NKG2C. The homodimeric activating receptor NKG2D increased in all patients. No significant differences in NK receptor expression between the donors and healthy volunteers was observed Conclusions: These results demonstrate changes in the NK receptor repertoire during the early post-transplant period that may have an impact on NK cells mediated cytotoxicity. No significant financial relationships to disclose.
Journal of Immunology | 1996
Crystal L. Mackall; Cathy Bare; L A Granger; Susan O. Sharrow; J A Titus; Ronald E. Gress
Blood | 1994
Crystal L. Mackall; Thomas A. Fleisher; Margaret Brown; Ian Magrath; Aziza Shad; Marc E. Horowitz; Leonard H. Wexler; Adde Ma; McClure Ll; Ronald E. Gress
Journal of Immunology | 1994
M Christ; Nancy McCartney-Francis; Ashok B. Kulkarni; Jerrold M. Ward; D E Mizel; Crystal L. Mackall; Ronald E. Gress; K. Hines; H Tian; Stefan Karlsson
American Journal of Pathology | 1995
Ashok B. Kulkarni; Jerrold M. Ward; L. Yaswen; Crystal L. Mackall; S. R. Bauer; Chang-Goo Huh; Ronald E. Gress; Stefan Karlsson
Journal of Immunology | 1995
Philip J. Lucas; C V Bare; Ronald E. Gress
Archive | 1999
Max A. Stafford; Yunzhen Cao; David D. Ho; Lawrence Corey; Crystal L. Mackall; Ronald E. Gress; Alan S. Perelson
Archive | 2004
Daniel H. Fowler; Ronald E. Gress