Ronald Grey
Vertex Pharmaceuticals
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Publication
Featured researches published by Ronald Grey.
Bioorganic & Medicinal Chemistry Letters | 2015
James A. Henderson; Darius Bilimoria; Monica Bubenik; Caroline Cadilhac; Kevin M. Cottrell; Evelyne Dietrich; Francois Denis; Nigel Ewing; Guy Falardeau; Simon Giroux; Ronald Grey; Lucille L’Heureux; Bingcan Liu; Nagraj Mani; Mark Morris; Olivier Nicolas; Oswy Z. Pereira; Carl Poisson; B. Govinda Rao; T. Jagadeeswar Reddy; Subajini Selliah; Rebecca S. Shawgo; Louis Vaillancourt; Jian Wang; Constantin Yannopoulos; Nathalie Chauret; Francoise Berlioz-Seux; Laval C. Chan; Sanjoy Kumar Das; Anne-Laure Grillot
The treatment of HCV with highly efficacious, well-tolerated, interferon-free regimens is a compelling clinical goal. Trials employing combinations of direct-acting antivirals that include NS5A inhibitors have shown significant promise in meeting this challenge. Herein, we describe our efforts to identify inhibitors of NS5A and report on the discovery of benzimidazole-containing analogs with subnanomolar potency against genotype 1a and 1b replicons. Our SAR exploration of 4-substituted pyrrolidines revealed that the subtle inclusion of a 4-methyl group could profoundly increase genotype 1a potency in multiple scaffold classes.
Archive | 2003
Albert Pierce; Michael J. Arnost; Robert J. Davies; Cornelia J. Forster; Vincent Galullo; Ronald Grey; Mark Ledeboer; Shi-Kai Tian; Jinwang Xu; Hayley Binch; Brian Ledford; David Messersmith; Suganthi Nanthakumar; Andrew Jayaraj; Greg Henkel; Francesco Salituro; Jian Wang
Archive | 2007
David J. Lauffer; Robert J. Davies; Dean Stamos; Alexander Aronov; David D. Deininger; Ronald Grey; Jinwang Xu; Pan Li; Brian Ledford; Luc J. Farmer; Randy S. Bethiel; Dylan Jacobs; Kira Mcginty
Archive | 2004
Michael J. Arnost; Guy W. Bemis; Robert J. Davies; Cornelia J. Forster; Ronald Grey; Mark Ledeboer; Brian Ledford; Craig Marhefka; David Messersmith; Albert Pierce; Francesco Salituro; Jian Wang
Archive | 2010
Alex Aronov; Jon H. Come; Robert J. Davies; Albert Pierce; Jian Wang; Suganthini Nanthakumar; Jingrong Cao; Upul K. Bandarage; Elaine Krueger; Amaud Le Tiran; Yusheng Liao; David Messersmith; Philip N. Collier; Ronald Grey; Hardwin O'dowd; James A. Henderson; Anne-Laure Grillot
Archive | 2003
Jeremy Green; Ronald Grey; Albert Pierce
Archive | 2008
David J. Lauffer; Robert J. Davies; Dean Stamos; Alexander Aronov; David D. Deininger; Ronald Grey; Jinwang Xu; Pan Li; Brian Ledford; Luc J. Farmer; Randy S. Bethiel; Dylan Jacobs; Kira Mcginty
Archive | 2012
James A. Henderson; John Maxwell; Louis Vaillancourt; Mark Morris; Ronald Grey; Simon Giroux; Laval Chan Chun Kong; Sanjoy Kumar Das; Bingcan Liu; Carl Poisson; Caroline Cadilhac; Monica Bubenik; T. Jagadeeswar Reddy; Guy Falardeau; Constantin Yannopoulos; Jian Wang; Oswy Z. Pereira; Youssef L. Bennani; Albert Pierce; Govinda Rao Bhisetti; Kevin M. Cottrell; Valerie Marone
Archive | 2018
Randy S. Bethiel; Jingrong Cao; Collier, Philip, N.; Robert J. Davies; Elisabeth Doyle; James Daniel Frantz; Brian Anthony Goldman; Ronald Grey; Anne-Laure Grillot; Wenxin Gu; Adrianne Lynne Kolpak; Paul Eduardo Krauss; Yusheng Liao; Sanjay Shivayogi Magavi; David Messersmith; Emanuele Perola; Ryu, Elizabeth, Jin-Sun; Joshua Syken; Jian Wang
Archive | 2017
Albert Pierce; Alex Aronov; Amaud Le Tiran; Anne Laure Grillot; David Messersmith; Elaine Krueger; Hardwin O'dowd; James A. Henderson; Jian Wang; Jingrong Cao; Jon Come; Philip N. Collier; Robert J. Davies; Ronald Grey; Suganthini Nanthakumar; Upul K. Bandarage; Yusheng Liao
