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Ronald Keith Webber

Pharmacia

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Publication

Featured researches published by Ronald Keith Webber.

Bioorganic & Medicinal Chemistry Letters | 2001

Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase

Alan E. Moormann; Sue Metz; Mihaly V. Toth; William M. Moore; Gina M. Jerome; Christine M. Kornmeier; Pamela T. Manning; Donald W. Hansen; Barnett S. Pitzele; Ronald Keith Webber

The potency and selectivity of a series of 5-hetero-2-iminohexahydroazepines were examined as inhibitors of the three human NOS isoforms. The effect of ring substitution of the 5-carbon for a heteroatom is presented. Potencies (IC(50)s) for these inhibitors are in the low micromolar range for hi-NOS with some examples exhibiting a 500x selectivity versus hec-NOS.

Journal of Medicinal Chemistry | 1994

L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase.

William M. Moore; Ronald Keith Webber; Gina M. Jerome; Foe S. Tjoeng; Thomas P. Misko; Mark G. Currie

Archive | 2001

Amidino compound and salts thereof useful as nitric oxide synthase inhibitors

Ronald Keith Webber; Richard C. Durley; Alok K. Awasthi; Arija A. Bergmanis; Scott S. Ganser; Timothy J. Hagen; E. Ann Hallinan; Donald W. Hansen; Brian S. Hickory; Alan E. Moormann; Barnett S. Pitzele; Michelle A. Promo; Richard R. Schartman; Jeffrey S. Snyder; Mahima Trivedi; Sofya Tsymbalov

Journal of Medicinal Chemistry | 1998

2-Iminohomopiperidinium salts as selective inhibitors of inducible nitric oxide synthase (iNOS)

Donald W. Hansen; Karen B. Peterson; Mahima Trivedi; Steven W. Kramer; Ronald Keith Webber; Foe S. Tjoeng; William M. Moore; Gina M. Jerome; Christine M. Kornmeier; Pamela T. Manning; Jane R. Connor; Thomas P. Misko; Mark G. Currie; Barnett S. Pitzele

Archive | 2001

Amidino compounds useful as nitric oxide synthase inhibitors

Ronald Keith Webber; Richard C. Durley; Alok K. Awasthi; Arijia A. Bergmanis; Kam F. Fok; Scott S. Ganser; Timothy J. Hagen; Ann E. Hallinan; Donald W. Hansen; Brian S. Hickory; Pamela T. Manning; Michael Mao; Alan E. Moormann; Barnett S. Pitzele; Michelle A. Promo; Richard R. Schartman; Jeffrey A. Scholten; Jeffrey S. Snyder; Mihaly V. Toth; Mahima Trivedi; Sofya Tsymbalov; Foe Siong Tjoeng

Archive | 2001

2-Amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors

Richard C. Durley; James A. Sikorski; Donald W. Hansen; Michelle A. Promo; Ronald Keith Webber; Barnett S. Pitzele; Alok K. Awasthi; Alan E. Moorman

Archive | 2001

2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors

Barnett S. Pitzele; James A. Sikorski; Donald W. Hansen; Ronald Keith Webber; Mihaly V. Toth; Jeffrey A. Scholten; Jeffrey S. Snyder

Archive | 2001

Halogenated 2-amino-4, 5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors

Donald W. Hansen; Ronald Keith Webber; Alok K. Awasthi; Pamela T. Manning

Archive | 2001

2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives useful as nitric oxide synthase inhibitors

Donald W. Hansen; Ronald Keith Webber; Barnett S. Pitzele; James A. Sikorski; Mark A. Massa; Timothy J. Hagen; Margaret L. Grapperhaus; Lijuan Jane Wang; Arija A. Bergmanis; Steven W. Kramer; E. Ann Hallinan

Archive | 2002

Prodrugs of substituted polycyclic compounds useful for selective inhibition of the coagulation cascade

Michael S. South; Ronald Keith Webber; Horng-Chih Huang; Mihaly V. Toth; Alan E. Moormann; Jeffery S. Snyder; Jeffrey A. Scholten; Danny J. Garland; Melvin L. Rueppel; William L. Neumann; Scott Long; Wei Huang; John Trujillo; John J. Parlow; Darin E. Jones; Brenda L. Case; Michael J. Hayes; Qingping Zeng

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Alok K. Awasthi

Pharmacia

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Timothy J. Hagen

Pharmacia

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Jeffrey S. Snyder

Pharmacia

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Michelle A. Promo

Pharmacia

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Donald W. Hansen

G. D. Searle

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Richard R. Schartman

Pharmacia

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Scott S. Ganser

Pharmacia

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Ann E. Hallinan

Pharmacia

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Pamela T. Manning

Pharmacia

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Richard C. Durley

Monsanto

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