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Dive into the research topics where Rosa Maria Cordeiro Soubhia is active.

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Featured researches published by Rosa Maria Cordeiro Soubhia.


American Journal of Nephrology | 2005

Tacrolimus and nonsteroidal anti-inflammatory drugs: an association to be avoided.

Rosa Maria Cordeiro Soubhia; Gloria E. Mendes; Francine Zocoler Mendonça; Maria Alice Sperto Ferreira Baptista; José Paulo Cipullo; Emmanuel A. Burdmann

Background: Tacrolimus (FK) and nonsteroidal anti-inflammatory drugs (NSAIDs) can cause acute nephrotoxicity. The expanding use of tacrolimus and the intense consumption of NSAIDS increase the chances of their simultaneous use. Methods: Rats receiving a nonselective COX inhibitor (diclofenac, D) and FK or a selective COX-2 inhibitor (rofecoxib, RO) and FK were treated with FK (2 mg/kg/day), D (10 mg/kg/day), RO (3 mg/kg/day), FK+D, FK+RO and vehicle for 7 days on low-salt diet. Results: Both associations significantly impaired glomerular filtration rate (GFR; 0.63 ± 0.06 ml/min/100 g in FK+D, 0.83 ± 0.06 ml/min/100 g in FK+RO) which did not occur with single drug therapy (0.98 ± 0.03 ml/min/100 g in D, 1.06 ± 0.04 ml/min/100 g in RO, 0.99 ± 0.05 ml/min/ 100 g in FK) or vehicle (1.10 ± 0.05 ml/min/100 g). GFR decrease was significantly higher with FK+D. GFR impairment occurred without RBF or RVR major changes. Mild tubular vacuolization and dilatation and acute degenerative changes were observed in tubular cells. FK+D animals showed a marked weight loss, not observed in the other groups. FK+NSAIDs association decreased FK blood levels (1.73 ± 0.3 ng/ml in FK+D, 1.8 ± 0.3 ng/ml in FK+RO, 3.2 ± 0.4 ng/ml in FK, p < 0.05). Conclusions: The association of FK and nonselective or COX-2 selective NSAIDs in salt-depleted animals caused a significant GFR impairment and decreased FK blood levels.


Ciencia & Saude Coletiva | 2011

Criação de banco de dados para sustentação da pós-eliminação em hanseníase

Vânia Del´Arco Paschoal; Susilene Maria Tonelli Nardi; Maria Rita de Cássia Oliveira Cury; Clovis Lombardi; Marcos da Cunha Lopes Virmond; Renée Matar Dourado Neta da Silva; José Antonio Armani Paschoal; Lílian Carla Magalhais; Ellen Carolina Marques Conte; Rosina Maria Martins Kubota; Rosa Maria Cordeiro Soubhia

São José do Rio Preto reached the World Health Organization goal eliminating leprosy as a Public Health problem in the year 2006, with a prevalence of 0.79/10,000 inhabitants. In order to warrant reliable information to promote management measures that keep this status, the aim of this study was to create a leprosy data bank in the city with information from 1998 to 2006. A data collection protocol was used and it contained 74 clinical-epidemiological variables that were gathered from primary and secondary sources. This work was initiated with 442 cases registered in the municipal control program database, from those 168 were excluded and 85 were inserted. There were 24 cases not notified in the National Information System (SINAN). The 74 variables collected will allow further studies about themes: epidemiological profiles, household contacts control, reactions and deficiencies, and others. The difficulties faced during the elaboration of the database were related to decoding medical files data and inconsistency in the SINAN. The frequent mistakes while entering the data weaken the information system and difficult the plan of precise actions regarding health. These facts are relevant to the quality of attention and the maintenance of the leprosy elimination status.


Anais Brasileiros De Dermatologia | 2013

Biological agents: investigation into leprosy and other infectious diseases before indication

João Roberto Antonio; Rosa Maria Cordeiro Soubhia; Vania Del Arco Paschoal; Carolina Forte Amarante; Ana Regina Franchi Trávolo

Biological agents are widely used for various immune-mediated diseases, with remarkable effectiveness in the treatment of rheumatoid arthritis (RA), psoriasis, psoriatic arthritis, ankylosing spondylitis and Crohns disease. However, attention needs to be drawn to the adverse effects of these therapies and the risk of reactivating underlying granulomatous infectious diseases such as tuberculosis, leprosy, syphilis, leishmaniasis, among others. The objective of this paper is to describe a case of leprosy in a patient with RA using anti-TNF alfa, demonstrating the need for systematic investigation of skin lesions suggestive of leprosy in patients who require rheumatoid arthritis therapeutic treatment, especially in endemic regions like Brazil.


Anais Brasileiros De Dermatologia | 2013

Correlation between dermoscopic and histopathological diagnoses of atypical nevi in a dermatology outpatient clinic of the Medical School of São José do Rio Preto, SP, Brazil

João Roberto Antonio; Rosa Maria Cordeiro Soubhia; Solange Corrêa Garcia Pires D'Avila; Adriana Cristina Caldas; Lívia Arroyo Trídico; Fernanda Tomé Alves

BACKGROUND The incidence of cutaneous melanoma is increasing worldwide. Since it is an aggressive neoplasm, it is difficult to treat in advanced stages; early diagnosis is important to heal the patient. Melanocytic nevi are benign pigmented skin lesions while atypical nevi are associated with the risk of developing melanoma because they have a different histological pattern than common nevi. Thus, the clinical diagnosis of pigmented lesions is of great importance to differentiate benign, atypical and malignant lesions. Dermoscopy appeared as an auxiliary test in vivo, playing an important role in the diagnosis of pigmented lesions, because it allows the visualization of structures located below the stratum corneum. It shows a new morphological dimension of these lesions to the dermatologist and allows greater diagnostic accuracy. However, histopathology is considered the gold standard for the diagnosis. OBJECTIVES To establish the sensitivity and specificity of dermoscopy in the diagnosis of pigmented lesions suspected of malignancy (atypical nevi), comparing both the dermatoscopic with the histopathological diagnosis, at the Dermatology Service of the outpatient clinic of Hospital de Base, São José do Rio Preto, SP. METHODS Analysis of melanocytic nevi by dermoscopy and subsequent biopsy on suspicion of atypia or if the patient so desires, for subsequent histopathological diagnosis. RESULTS Sensitivity: 93%. Specificity: 42%. CONCLUSIONS Dermoscopy is a highly sensitive method for the diagnosis of atypical melanocytic nevi. Despite the low specificity with many false positive diagnoses, the method is effective for scanning lesions with suspected features of malignancy.


Arq. ciênc. saúde | 2011

Avaliação epidemiológica dos estados reacionais e incapacidades físicas em pacientes com hanseníase na cidade de São José do Rio Preto

João Roberto Antonio; Rosa Maria Cordeiro Soubhia; Vânia Del’Arco Paschoa; Guilherme Bueno de Oliveira; Natália Cristina Pires Rossi; Marina Gagheggi Maciel; Susilene Maria Tonelli Nardi


Arq. ciênc. saúde | 2009

Situação epidemiológica da hanseníase no município de São José do Rio Preto, SP, Brasil

Ellen Carolina Marques Conte; Lílian Carla Magalhais; Maria Rita de Cássia Oliveira Cury; Rosa Maria Cordeiro Soubhia; Susilene Maria Tonelli Nardi; Vânia Del´Arco Paschoal; Clovis Lombardi


RBM rev. bras. med | 2013

Micobacterioses relacionadas às terapias com imunobiológicos (anti-TNF-a)

Gilberto de Camargo Soubhia Filho; Natália Cristina Pires Rossi; Rosa Maria Cordeiro Soubhia; Liyoko Okino


Archive | 2013

Biological agents: investigation into leprosy and other infectious diseases before indication * Agentes biológicos: pesquisa de hanseníase e outras doenças infecciosas antes da indicação

João Roberto Antonio; Rosa Maria Cordeiro Soubhia; Vania Del Arco Paschoal; Carolina Forte Amarante


Archive | 2011

Melanoma cutâneo primário: estudo retrospectivo de 2000 a 2009 em um Hospital de Ensino no interior do Estado de São Paulo

Estela Ferreira David; Fabiana Gual; Fauze Abdulmassih Gonçalves; Luciano Garcia; Izabela Lídia; Soares Cardeal; Ricardo Thompson Nóra; Rosa Maria Cordeiro Soubhia; Carlos Roberto Antonio; Eurides Maria de Oliveira Pozetti; João Roberto Antonio


Revista brasileira de medicina | 2005

Fenomeno de Lucio

João Roberto Antonio; José Paulo Cipullo; Rosa Maria Cordeiro Soubhia; Solange Corrêa Garcia Pires D'Avila; Dalisio de Santi-Neto; Flávia Aparecida Pereira; Cristiano Tárzia Kakihara

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João Roberto Antonio

Faculdade de Medicina de São José do Rio Preto

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Solange Corrêa Garcia Pires D'Avila

Faculdade de Medicina de São José do Rio Preto

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Ellen Carolina Marques Conte

Faculdade de Medicina de São José do Rio Preto

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Maria Rita de Cássia Oliveira Cury

Faculdade de Medicina de São José do Rio Preto

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Natália Cristina Pires Rossi

Faculdade de Medicina de São José do Rio Preto

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Vânia Del´Arco Paschoal

Faculdade de Medicina de São José do Rio Preto

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Adriana Cristina Caldas

Faculdade de Medicina de São José do Rio Preto

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