Rosa Sapena
University of Paris
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Featured researches published by Rosa Sapena.
Leukemia Research | 2010
Sophie Park; Charikleia Kelaidi; Rosa Sapena; D. Vassilieff; Odile Beyne-Rauzy; Valérie Coiteux; Norbert Vey; Christophe Ravoet; Stéphane Cheze; Christian Rose; Laurence Legros; Aspasia Stamatoullas; Martine Escoffre-Barbe; Agnès Guerci; M.P. Chaury; Pierre Fenaux; Francois Dreyfus
ESAs are increasingly used to treat anemia of lower risk MDS, even before RBC transfusion requirement. From a previously published patient cohort treated with ESAs, we selected 112 patients with de novo low or int-1 IPSS MDS with Hb<10 g/dl, serum EPO<500 UI/l and who had never been transfused. Erythroid response rate at 12 weeks was 63.1% (IWG 2006). In multivariate analysis, an interval between diagnosis and ESA onset<6 months, Hb level>9 g/dl, and serum EPO<100 UI/l predicted better response to ESA while shorter interval between diagnosis and ESA onset (p=0.01), lower serum EPO (p=0.04) and WHO diagnosis of RCMD-RS (p=0.03) were associated with longer response. Median interval from diagnosis to transfusion dependency was 80 months and 35 months, respectively, in patients with onset of ESA < 6 months and ≥ 6 months from diagnosis (p=0.007). Those results support early onset of ESA in lower risk MDS, to better avoid the consequences of anemia. Early introduction of ESA may also delay the need for RBC transfusions, hypothetically by slowing the disease course, but prospective studies are required to further assess this point.
Blood | 2013
Valeria Santini; Jennifer Schemenau; Alessandro Levis; Enrico Balleari; Rosa Sapena; Lionel Ades; Agnès Guerci; Odile Beyne-Rauzy; Marie Pierre Gourin; Stéphane Cheze; Aspasia Stamatoullas; Alessandro Sanna; Daniela Gioia; Gianni Cametti; Dario Ferrero; Emmanuel Raffoux; Christian Rose; Antonella Poloni; Thomas Prebet; Laurence Legros; Shanti Natarajan-Amé; Pierre Fenaux; Ulrich Germing; Francois Dreyfus; Sophie Park
To the editor: The “classical” International Prognostic Scoring System (IPSS), based on cytogenetics, marrow blast percentage, and number of cytopenias, has played a major role in prognosis assessment in myelodysplastic syndromes (MDS).[1][1] The recently published revised IPSS (IPSS-R), using
Leukemia Research | 2011
Thorsten Braun; Stéphane de Botton; Anne-Laure Taksin; Sophie Park; Odile Beyne-Rauzy; Valérie Coiteux; Rosa Sapena; Anne Lazareth; Geneviève Leroux; Khaled Guenda; Bruno Cassinat; Michaela Fontenay; Norbert Vey; Agnès Guerci; Francois Dreyfus; Dominique Bordessoule; Aspasia Stamatoullas; Sylvie Castaigne; Christine Terré; Virginie Eclache; Pierre Fenaux; Lionel Ades
Isolated 20q deletion is common in MDS and considered of good prognosis, but no large series have been reported. We compared characteristics of 62 MDS patients with isolated del 20q, 36 patients with del 20q and other cytogenetic abnormalities, and 1335 MDS patients without del20q. Significant differences between MDS with isolated del 20q and patients without del 20q were lower platelet count (mean 144 vs. 196 G/l, p=0.005), lower marrow blast count (mean 3.9% vs. 5.6%, p=0.0008), and higher reticulocyte count (mean 72.5 vs. 51.7 G/l, p=0.04). Ten (16%) patients with isolated del 20q had Hb>12 g/dl and platelets <100 G/l, compared to 7.3% of patients without del 20q (p=0.025). Review of marrow slides of those 10 patients showed that could be readily identified as MDS prior to cytogenetics. Fourteen percent of patients with isolated del 20q progressed to AML compared to 11% with one and 24% with several additional abnormalities. Median survival was 54 months in patients with isolated del 20q, not reached and 12 months for del 20q with one and several additional abnormalities, respectively (p=0.035) confirming the favorable prognosis of del 20q without complex abnormalities.
Journal of Clinical Oncology | 2017
Sophie Park; Jean François Hamel; Andrea Toma; Charikleia Kelaidi; Sylvain Thepot; Maria Diez Campelo; Valeria Santini; Mikkael A. Sekeres; Enrico Balleari; Jennifer Kaivers; Rosa Sapena; Katharina Götze; Catharina Müller-Thomas; Odile Beyne-Rauzy; Aspasia Stamatoullas; Ioannis Kotsianidis; Rami S. Komrokji; David P. Steensma; Jaime Fensterl; Gail J. Roboz; Teresa Bernal; Fernando Ramos; Marisa Calabuig; Agnès Guerci-Bresler; Dominique Bordessoule; Pascale Cony-Makhoul; Stéphane Cheze; Eric Wattel; Christian Rose; Norbert Vey
Purpose Most anemic patients with non-deleted 5q lower-risk myelodysplastic syndromes (MDS) are treated with erythropoiesis-stimulating agents (ESAs), with a response rate of approximately 50%. Second-line treatments, including hypomethylating agents (HMAs), lenalidomide (LEN), and investigational drugs, may be used after ESA failure in some countries, but their effect on disease progression and overall survival (OS) is unknown. Here, we analyzed outcome after ESA failure and the effect of second-line treatments. Patients and Methods We examined an international retrospective cohort of 1,698 patients with non-del(5q) lower-risk MDS treated with ESAs. Results Erythroid response to ESAs was 61.5%, and median response duration was 17 months. Of 1,147 patients experiencing ESA failure, 653 experienced primary failure and 494 experienced relapse after a response. Primary failure of ESAs was associated with a higher risk of acute myeloid leukemia (AML) progression, which did not translate into an OS difference. Of 450 patients (39%) who received second-line treatment, 194 received HMAs, 148 received LEN, and 108 received other treatments (MISC), whereas 697 received RBC transfusions only. Five-year AML cumulative incidence was 20.3%, 20.3%, and 11.3% for those receiving HMAs, LEN, and MISC, respectively ( P = .05). Five-year OS for patients receiving HMA, LEN, and MISC was 36.5%, 41.7%, and 51%, respectively ( P = .21). In a multivariable analysis adjusted for age, sex, revised International Prognostic Scoring System score, and progression at ESA failure, there was no significant OS difference among the three groups. Conclusion In this large, multicenter, retrospective cohort of patients with non-del(5q) lower-risk MDS treated with ESAs, none of the most commonly used second-line treatments (HMA and LEN) significantly improved OS. Early failure of ESAs was associated with a higher risk of AML progression.
Leukemia Research | 2011
Sophie Park; Rosa Sapena; Charikleia Kelaidi; D. Vassilieff; Dominique Bordessoule; Aspasia Stamatoullas; Stéphane Cheze; Odile Beyne-Rauzy; Norbert Vey; Christian Rose; Agnès Guerci; Shanti Natarajan-Amé; Gérard Tertian; Borhane Slama; Pierre Fenaux; F. Dreyfus
We evaluated the prognostic value of serum ferritin (SF) level at diagnosis in 318 newly diagnosed IPSS low and int 1 (lower) risk MDS patients included in the French MDS registry, who did not require RBC transfusions and had baseline SF level determination. Increased baseline SF level (>300 ng/ml) was correlated with male gender, more pronounced anaemia, and diagnosis of RARS but had no negative impact on progression to AML or survival.
British Journal of Haematology | 2016
Emmanuel Gyan; Valérie Andrieu; Alessandro Sanna; Agnès Caille; Jennifer Schemenau; Isabelle Sudaka; Virginie Siguret; Michèle Malet; Sophie Park; Dominique Bordessoule; Jacques Mairesse; Véronique Gelsi-Boyer; Stéphane Cheze; Odile Beyne-Rauzy; Marie Sebert; Rosa Sapena; Hacene Zerazhi; Laurence Legros; Agnès Guerci-Bresler; Shanti Ame; Ulrich Germing; Valeria Santini; Flavia Salvi; Daniela Gioia; Monia Lunghi; Francois Dreyfus; Pierre Fenaux
Florian Scherer Marlon van der Burgt Szymon M. Kiełbasa Cristina Bertinetti-Lapatki Marcus D€ uhren von Minden Kristina Mikesch Katja Zirlik Liesbeth de Wreede Hendrik Veelken Marcelo A. Navarrete Department of Haematology and Oncology, University Medical Centre Freiburg, Freiburg, Germany, Department of Haematology, Leiden University Medical Centre, Department of Medical Statistics and Bioinformatics, Leiden University Medical Centre, Leiden, The Netherlands, Centre for Biological Signalling Studies (BIOSS), Albert-Ludwigs University Freiburg, Freiburg, Germany, and School of Medicine, University of Magallanes, Punta Arenas, Chile. E-mail: [email protected]
British Journal of Haematology | 2018
Louis Drevon; Alice Marceau; Odile Maarek; Wendy Cuccuini; Emmanuelle Clappier; Virginie Eclache; Thomas Cluzeau; Valentine Richez; Inès Berkaoui; Sophie Dimicoli-Salazar; Audrey Bidet; Jean-Philippe Vial; Sophie Park; Christina Vieira Dos Santos; Eléonore Kaphan; Céline Berthon; Aspasia Stamatoullas; François Delhommeau; Nassera Abermil; Thorsten Braun; Rosa Sapena; Daniel Lusina; Aline Renneville; Lionel Ades; Sophie Raynaud; Pierre Fenaux
Isolated trisomy 8 (+8) is a frequent cytogenetic abnormality in the myelodysplastic syndromes (MDS), but its characteristics are poorly reported. We performed a retrospective study of 138 MDS patients with isolated +8, classified or reclassified as MDS (excluding MDS/myeloproliferative neoplasm). Myeloproliferative (MP) features were defined by the repeated presence of one of the following: white blood cell count >10 × 109/l, myelemia (presence of circulating immature granulocytes with a predominance of more mature forms) >2%, palpable splenomegaly. Fifty‐four patients (39·1%) had MP features: 28 at diagnosis, 26 were acquired during evolution. MP forms had more EZH2 (33·3% vs. 12·0% in non‐MP, P = 0·047), ASXL1 (66·7% vs. 42·3%, P = 0·048) and STAG2 mutations (77·8% vs. 21·7%, P = 0·006). Median event‐free survival (EFS) and overall survival (OS) were 25 and 27 months for patients with MP features at diagnosis, versus 28 (P = 0·15) and 39 months (P = 0·085) for those without MP features, respectively. Among the 57 patients who received hypomethylating agent (HMA), OS was lower in MP cases (13 months vs. 23 months in non‐MP cases, P = 0.02). In conclusion, MP features are frequent in MDS with isolated +8. MP forms had more EZH2, ASXL1 and STAG2 mutations, responded poorly to HMA, and tended to have poorer survival than non‐MP forms.
Blood | 2016
M. Sebert; Cecile Bally; Pierre Peterlin; Odile Beyne-Rauzy; Laurence Legros; Marie Pierre Gourin; Laurence Sanhes; Eric Wattel; Emmanuel Gyan; Sophie Park; Aspasia Stamatoullas; Anne Banos; Kamel Laribi; Simone Jueliger; Luke Bevan; Cendrine Chaffaut; Rosa Sapena; Benedicte Samey; Fatiha Chermat; Sylvie Chevret; Lionel Ades; Pierre Fenaux
Blood | 2015
S. Park; Jean-François Hamel; Andrea Toma; Charikleia Kelaidi; María Díez; Valeria Santini; Enrico Balleari; Jennifer Schemenau; Rosa Sapena; Katharina Goetze; Catharina Mueller-Thomas; Odile Beyne-Rauzy; Aspasia Stamatoullas; Ioannis Kotsianidis; Agnès Guerci; Dominique Bordessoule; Pascale Cony-Makhoul; Stéphane Cheze; Eric Wattel; Christian Rose; Norbert Vey; Ulrich Germing; Guillermo Sanz; Francois Dreyfus; Pierre Fenaux
Leukemia Research | 2011
Emmanuel Gyan; V. Andrieu; A. Caille; S. Park; Aspasia Stamatoullas; V. Sélosse; Dominique Bordessoule; Véronique Gelsi-Boyer; L. Ades; N. Vey; Stéphane Cheze; Odile Beyne-Rauzy; Rosa Sapena; H. Zerazhi; Laurence Legros; Agnès Guerci-Bresler; Pierre Fenaux; F. Dreyfus