Rosaria D'urso
Sapienza University of Rome
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Featured researches published by Rosaria D'urso.
Life Sciences | 1996
P. Falaschi; Rosaria D'urso; Antonella Proietti; Antonio Martocchia; Renato Pastore; Luciano Angelucci
Recent studies pointed out the development of autoimmune thyroid diseases during interferon (IFN) therapy, mainly in patients with positive thyroid autoantibodies (MsAb and TgAb) before treatment. The effects of recombinant human IFN alpha (rhIFNalpha) on thyroid function and thyroid autoantibodies were studied in 12 patients with chronic active hepatitis associated with virus B or C, selected on the basis of negative results for MsAb and TgAb. No significant variation in T3, T4 and TSH levels was observed either after the first administration of rhIFN alpha (3 million IU i.m.) or after three months of therapy (3 million IU i.m. 3 times a week). TSH response to TRH was in the normal range either before or after the therapy. The absence of MsAb and TgAb was confirmed in all the patients at the end of the treatment. These results indicate that no patient developed thyroid disorder during IFN therapy. Nevertheless, since positive MsAb and TgAb have been considered as a risk factor for thyroid diseases, in patients selected for IFN therapy they should be carefully assessed for autoantibodies before undergoing IFN treatment.
Life Sciences | 1982
Paolo Falaschi; Antonio Rocco; Rosaria D'urso; Renata Jellamo; Gino Toffano; Gaetano Frajese
Bovine brain phospholipid liposomes (BC-PL) reduce plasma prolactin (PRL) levels in humans after acute administration and counteract the metoclopramide- and sulpiride-induced hyperprolactinaemia. However, BC-PL, like nomifensine, a dopamine (DA) reuptake inhibitor and therefore an indirect dopaminergic compound, does not influence TRH-induced hyperprolactinaemia. Moreover, BC-PL and nomifensine reduce plasma PRL levels in hyperprolactinaemic PCO syndromes but not in PRL secreting pituitary adenomas. The results obtained indicate that BC-PL antagonizes the DA blockade-induced hyperprolactinaemia and that the main site of action of BC-PL seems to be at the hypothalamic level; however a concomitant pituitary effect cannot be ruled out.
Acta Cytologica | 2016
Edoardo Virgilio; Enrico Giarnieri; Monica Montagnini; Rosaria D'urso; Antonella Proietti; Alessandra Mesiti; Maria Rosaria Giovagnoli; Paolo Mercantini; Marco Cavallini; Genoveffa Balducci
Objectives: To investigate gastric lavage (GL) cytopathology and immunometric analysis as novel clinicopathologic and prognostic parameters for gastric cancer (GC). Study Design: In 38 patients with gastric adenocarcinoma, we performed a cytopathologic analysis and an immunometric assay of GL using four tumor markers (CEA, CA 19.9, CA 72.4, and CA 50). The intragastric tumor marker levels were compared with a control group consisting of 41 non-GC patients to determine a statistically significant cutoff value. Results: GL cytopathology demonstrated the presence of cancer cells in 13 (34.2%) of the 38 GC patients: such a finding correlated to the parameters pT and pN with a statistically significant validity (p < 0.0267 and p < 0.0306, respectively). Measurement of intragastric CA 19.9 and CA 50 attained a statistically significant cutoff value (p < 0.002 and p < 0.0096, respectively), which was invalidated by the low sensitivity of the ROC curve analysis. Conclusions: In contrast to determination of its tumor markers, GL cytopathology correlated well with pT and pN staging parameters. Should this and other features be corroborated by future studies, the GL cytology test could be routinely used to detect aggressive types of GC even at early stages and result in important progress in the knowledge, staging, prediction, as well as management and follow-up of this inauspicious type of cancer.
Neuro endocrinology letters | 2001
Paolo Falaschi; Antonio Martocchia; Antonella Proietti; Rosaria D'urso; Giovanni Antonini
Neuro endocrinology letters | 2004
Paolo Falaschi; Antonio Martocchia; Antonella Proietti; Rosaria D'urso; Gargano S; Culasso F; Antonio Rocco
Anticancer Research/Open Access Articles | 2017
Edoardo Virgilio; Antonella Proietti; Rosaria D'urso; Patrizia Cardelli; Enrico Giarnieri; Monica Montagnini; Maria Rosaria Giovagnoli; Paolo Mercantini; Genoveffa Balducci; Marco Cavallini
Annals of the New York Academy of Sciences | 1994
Paolo Falaschi; Antonio Martocchia; Antonella Proietti; Renato Pastore; Rosaria D'urso
Anticancer Research | 2018
Edoardo Virgilio; Enrico Giarnieri; Maria Rosaria Giovagnoli; Monica Montagnini; Antonella Proietti; Rosaria D'urso; Paolo Mercantini; Genoveffa Balducci; Marco Cavallini
Annals of the New York Academy of Sciences | 1994
Paolo Falaschi; Antonio Martocchia; Antonella Proietti; Renato Pastore; Rosaria D'urso
Medical Hypotheses | 2018
Edoardo Virgilio; Genoveffa Balducci; Paolo Mercantini; Enrico Giarnieri; Maria Rosaria Giovagnoli; Monica Montagnini; Antonella Proietti; Rosaria D'urso; Marco Cavallini