Rosario Spina

The use of point-of-care bedside lung ultrasound significantly reduces the number of radiographs and computed tomography scans in critically ill patients.

BACKGROUND: Chest radiography has been reported to have low diagnostic accuracy in critically ill intensive care unit (ICU) patients, and chest computed tomography (CT) scans require patients to be transported out of the ICU, putting them at risk of adverse events. In this study we assessed the efficacy of routine bedside lung ultrasound (LUS) in the evaluation of pleural effusions (PE) in the ICU. METHODS: Three hundred seventy-six patients admitted to the ICU for major trauma (46.3%), medical pathology (41.5%), and postsurgical complications (12.2%) (May 2008 to April 2009) were included in this study. Patients were placed into either the control group (group C) or the study group (group S), on the basis of the introduction of routine LUS performed by a single group of intensivists in 1 tertiary care ICU. To reduce provider bias, the physicians conducting the LUS were not aware of the study. Collected data included patient demographics, clinical course, and number of chest radiographs and CT scans performed. As a secondary goal, we assessed the reliability of Baliks formula in PE estimation. RESULTS: No significant differences were found between the 2 groups with regard to their demographics and ICU clinical course. Group S had a significant reduction in the total number of chest radiographs obtained (−26%; P < 0.001) and CT scans (−47%; P < 0.001) in comparison with the comparison group C. A 6-month follow-up analysis of the ICU LUS protocol revealed a time-dependent decrease in the number of radiological examinations requested for patients with PE. Lastly, PE volume estimation using the LUS and Baliks formula correlates well with the effective volume drained (r = 0.65; P < 0.0001). CONCLUSIONS: Routine use of LUS in the ICU setting can be associated with a reduction of the number of chest radiographs and CT scans performed.

Implantation of 3951 long-term central venous catheters: performances, risk analysis, and patient comfort after ultrasound-guidance introduction.

BACKGROUND: Despite evidence demonstrating improved safety with ultrasound-guided placement of central venous catheters (CVC) in comparison with the use of anatomical landmarks, ultrasound guidance is still not routinely used by all physicians when obtaining central venous access. METHODS: We report data pertaining to the placement of long-term CVCs in a 7-year period before and after ultrasound guidance was introduced. We included 3951 procedures (total of 1,642,402 catheter days) in our study: 1584 using the anatomical landmark method (landmark group, January 2000 to May 2003), and 2367 with ultrasound guidance (ultrasound group, June 2003 to May 2007). All procedures were performed by the same team of intensivists. Comparison criteria included procedural data, complications, patients comfort, and perceptions. Variables were analyzed with Students t test and &khgr;2 test. Multivariate analysis was performed according to the Cox proportional hazards regression model. RESULTS: Using ultrasound guidance, we noted a significant reduction in procedure time in both port (mean difference 4.9 ± 0.4 minutes, confidence interval [CI] 4.1 to 5.7) and tunneled catheter (mean difference 2.4 ± 0.8 minutes, CI 0.9 to 3.8) placement. The landmark method was associated with an increased risk of overall perioperative complications (4.5, CI 3.6 to 5.6). Among disease entities, acute leukemia patients had a significantly higher risk of CVC-related infections (2.6, CI 2.1 to 3.8). On the basis of questionnaires submitted to patients from both groups, ultrasound guidance was associated with improved patient comfort and satisfaction. CONCLUSIONS: Ultrasound guidance reduces complications and improves patient comfort. Further studies are needed to define whether acute leukemia patients should be considered a separate category with regard to the higher incidence of infections.

Glomerular permeability and trauma: A correlation between microalbuminuria and Injury Severity Score

OBJECTIVE To determine if there is a correlation between an increase in glomerular permeability, the magnitude of trauma, and the severity of illness. DESIGN Prospective study. SETTING Two university hospital intensive care units. PATIENTS Forty consecutive critically ill trauma patients admitted directly to the intensive care unit within 120 mins of their injuries. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS For each patient, urine was collected from the time of admission until 7 am the next day. Within 48 hrs, only one sample of all urine collected (5 mL) was examined for microalbuminuria and urinary creatinine. Results were expressed as the microalbuminuria/urinary creatinine ratio (MACR). The mortality rate in the intensive care unit, Injury Severity Score at the moment of admission, Acute Physiology and Chronic Health Evaluation III score, and Simplified Acute Physiology Score in the first 24 hrs were calculated for each patient. The data were analyzed using the Pearson test for linear regression and Students t-test. During the first 24 hrs after trauma, there was an increase of MACR (6.9 +/- 0.6 mg/mmol) above normal (reference range, <3 mg/mmol) that was positively correlated with Injury Severity Score (31.4 +/- 1.9; r2 = .73, p < .05). However, there was no correlation between MACR, Acute Physiology and Chronic Health Evaluation III score, Simplified Acute Physiology Score, and mortality rate. CONCLUSIONS Patients with trauma show an increase in glomerular permeability during the first 24 hrs after injury. The magnitude of this increase is correlated with the extent of trauma but does not seem significant enough to be predictive of severity of illness and/or outcome.

Early tracheostomy in intensive care unit: a retrospective study of 506 cases of video-guided Ciaglia Blue Rhino tracheostomies.

BACKGROUND Percutaneous dilatational tracheostomy (PDT) is a common procedure in critically ill patients, but the correct timing is still controversial. This study was designed to establish whether an early timing in video-guided Ciaglia Blue Rhino PDT affects the duration of mechanical ventilation (MV) and the length of stay (LOS) in intensive care unit (ICU). Secondary clinical outcomes were the overall hospitalization duration and the mortality rate. METHODS A retrospective, single-center study of 2,210 patients admitted to the ICU of the Emergency Department of the Careggi Teaching Hospital (Florence, Italy) between 2002 and 2007. Among the 506 patients who underwent PDT, 256 and 250 patients were retrospectively assigned to the early tracheostomy (ET) or late tracheostomy (LT) group according to whether the procedure was performed before (ET) or after (LT) 3 days of MV (median time of procedure execution). RESULTS The two groups of patients showed comparable demographic and clinical characteristics. The video-guided PDT procedures were performed without major complications in all cases. The average timing of tracheostomy in the ET group was 1.9 +/- 0.9 days, whereas in LT group resulted 6.8 +/- 3.8 days (mean +/- SD). Total hospital LOS and mortality rate were not different between the two groups. However, the duration of MV days and of ICU LOS group were significantly shorter in the ET group (13.3 +/- 9.6 and 16.9 +/- 13.0 days, respectively; p = 0.0001) than in the LT group (16.7 +/- 8.3 days and 20.8 +/- 9.2 days, respectively; p < 0.0001). Stratified analysis by the three major ICU admission diagnosis confirmed that both traumatized and nontraumatized (medical and postsurgical) ET patients had a shorter MV duration and ICU LOS as compared with LT patients. CONCLUSIONS Video-guided Ciaglia Blue Rhino PDT is safe and easy to perform in ICU. No difference in overall hospital LOS, incidence of pneumonia, and mortality rate between the ET and LT groups was found. However, in both traumatized and nontraumatized patients, shortened duration of ICU LOS and MV in the ET group (<or=3 days) indicates this procedure as a useful approach for patients and healthcare system.

The value of lung ultrasound monitoring in H1N1 acute respiratory distress syndrome

We present the case of a healthy young male who developed acute respiratory failure as a result of infection with influenza A/H1N1 of swine‐origin and in whom ventilatory support was optimised and recovery of lung function was monitored by the use of sequential chest ultrasound examinations. The potential pivotal role of bedside lung ultrasonography in H1N1‐induced respiratory failure is discussed.

Vacuum‐assisted closure for managing neck abscesses involving the mediastinum

A 57‐year‐old immunocompetent male patient with a deep neck abscess involving the mediastinum was referred to us following unsuccessful treatment at his local hospital with medical therapy and ultrasound‐guided aspiration. After initial evaluation and resuscitation, a contrast‐enhanced computed tomography (CT) scan was performed, and the patient was transferred for surgical drainage. A vacuum‐assisted closure (VAC) device was used as a surgical drain to help prevent reaccumulation of the purulent collections. A repeat CT scan on day 3 confirmed the absence of residual pus in the mediastinum and in the neck spaces, and the VAC device was removed. Perfect healing of the deep tissues with successful mediastinal toilette was observed. The patient resumed oral meals on postoperative day 10, and 2 days later he was discharged. A 1‐month follow‐up CT again demonstrated the complete healing and absence of the neck abscess. This case illustrates the possibility of avoiding more extensive and life‐threatening procedures, such as open thoracotomy, in the treatment of neck abscesses extending into the mediastinum, and highlights the utility of VAC in the management of deep neck abscesses. Laryngoscope, 2012

Diagnosis of carotid arterial injury in major trauma using a modification of Memphis criteria

BackgroundIncidence of Blunt Cerebrovascular Injuries (BCVI) after head injury has been reported as 0.5-1% of all admissions for blunt trauma, with a high stroke and mortality rate. The purpose of this study is to evaluate if a modification of Memphis criteria could improve the rate of BCVI diagnosis.MethodsTrauma patients consecutively admitted to Intensive Care Unit (ICU) from Jan 2008 to Oct 2009 were considered for the study. Memphis criteria comprehend: basilar skull fracture with involvement of the carotid canal, cervical spine fracture, neurological exam not explained by brain imaging, Horners syndrome, LeFort II-III fractures, and neck soft tissue injury. As single criteria modification, we included all patients with petrous bone fracture, even without carotid canal involvement. In all patients at risk of BCVI, 64-slice angio-CT-scans was performed.ResultsDuring the study period, 266 patients were admitted to the ICU for blunt major trauma. Among them, 162 presented traumatic brain injury or cervical spine fracture. In accordance with the proposed modified-Memphis criteria, 53 patients showed risk factors for BCVI compared to 45 using the original Memphis criteria. Among the 53 patients, 6 resulted as having carotid lesions (2.2% of all blunt major traumas; one patient more than when using Memphis criteria). Anticoagulant therapy with low molecular weight heparin was administered in all patients. No stroke or hemorrhagic complications occurred. Clinical examination at 6-months showed no central neurological deficit.ConclusionA modification of a single criteria of Memphis screening protocol might permit the identification of a higher percentage of BCVI. Limited by sample size, this study needs to be validated.

Pneumopericardium after major trauma.

CASE REPORT A 20-year-old male, after falling from 15 meters, reported a major trauma that consisted with hemorrhagic shock, PNX and pneumopericardium, lung contusions, retroperitoneal bleeding, lumbar vertebral fractures, leg and arm multiple fractures. The patient, in emergency room, was intubated and submitted to first-line diagnostic evaluation for major trauma that revealed a negative for intra-abdominal bleeding FAST, and a negative for PNX thorax Rx. Because an episode of hypotension and hypoxemia with reduction of breathing sound in right thorax, a chest drainage tube was inserted in midclavear line on the second intercostal space. The maneuver was successful and the symptoms were reduced. But, during computed tomography scan evaluation, the patient developed a new hypotension, hypoxemia, edema and cyanosis of the neck and superior thorax, and jugular veins over distension. The computed tomography scan of thorax revealed a tension PNX and pneumopericardium (Fig. 1). Therefore, the physician inserted a tube in the fifth intercostals space in axillary line that resolved the PNX and the pneumopericardium too (Fig. 2).

Experimental measurement of forces during percutaneous dilatational tracheostomy

The measurement of mechanical effects associated with the dilatation phase of a percutaneous dilatational tracheostomy is of primary importance to identify the causes of major complications associated with this procedure, such as tracheal cartilage subluxation or fracture and bleeding. Such information can be very useful also for the design of better instruments and procedures. The aim of this study was to present a methodology to evaluate mechanical effects of the dilatation phase of a percutaneous dilatational tracheostomy on the tracheal rings and adjacent anatomical structures. Forces and moments were measured through a dilator instrumented with strain gauges. Two surgeons, with different levels of expertise, performed the percutaneous dilatational tracheostomy on a lifelike reproduction of an adult head, specifically designed for training professionals. The modified dilator was effective in measuring forces involved in the percutaneous dilatational tracheostomy without affecting the ability of the operator to perform the procedure. The main contribution to the insertion of the dilator was given by the axial force, defined as the force acting on the handle, compressing it (mean and peak force: 48.8 and 88.2 N for Surgeon 1, 31.3 and 82.8 N for Surgeon 2, respectively). The proposed method was effective in measuring differences between procedures performed by surgeons with different amounts of experience in terms of duration, forces applied and repeatability. In addition, it may have applications for use as a feedback for incorrect positioning or excessively variable pressure during the training of surgeons for the execution of percutaneous dilatational tracheostomy.

Short-term outcome in major trauma: land versus air emergency medical rescue in Tuscany

Trauma is the major cause of death for people younger than 40 years in developed counties. In Italy an incidence of 120 deaths per 100,000 inhabitants for trauma is reported. An efficient emergency medical response system (EMRS) must therefore be assured in order to provide adequate treatment on the scene and allow a quick rescue to a referral hospital centre.