Roscoe R. Robinson

Fixed and Reproducible Orthostatic Proteinuria: Results of a 20-Year Follow-up Study

A 20-year follow-up evaluation of young men with fixed and reproducible orthostatic proteinuria showed no evidence of progressive renal disease. Follow-up information was obtained on 43 of the original 64 patients and detailed information was secured on 36. All had normal renal function and only six patients continued to show qualitative proteinuria. The prevalence of hypertension found was similar to that of a comparably aged group of the general population. The 20-year prognosis of patients with fixed and reproducible orthostatic proteinuria is excellent.

Peripheral and Renal Venous Plasma Renin Activity in Hypertension

Abstract One hundred eleven patients including 58 with normal renal arteries and 53 with renal artery lesions were studied with emphasis on the value of peripheral and renal venous plasma renin act...

Plasma renin activity in renovascular hypertension

Abstract Plasma renin activity was measured in forty-eight hypertensive patients with angiographie evidence of unilateral or bilateral occlusive disease of a main stem renal artery. Increased plasma renin activity in patients with unilateral renal arterial lesions was almost always (96 per cent) predictive of a satisfactory response to subsequent and technically successful surgery. In contrast, when plasma renin activity was normal, technically successful surgical intervention was not associated with a postoperative reduction of blood pressure. These data demonstrate that measurements of plasma renin activity in hypertensive patients with unilateral renal arterial disease provide an excellent guide to the success or failure of subsequent surgical therapy. Further studies are required to determine whether measurements of plasma renin activity are similarly useful in hypertensive patients with bilateral renal arterial lesions.

Juxtaglomerular hyperplasia and hyperreninemia in progressive systemic sclerosis complicated by acute renal failure

Abstract The etiology of renal failure in progressive systemic sclerosis remains unexplained. In this patient with progressive systemic sclerosis rapidly progressive azotemia developed resulting in death. Kidney tissue obtained by percutaneous renal biopsy and later at autopsy revealed striking hyperplasia of the juxtaglomerular apparatus. The plasma renin activity measured by bioassay was extremely high. The clinical and morphologic findings in this patient suggest a possible pathophysiologic role for the renin-angiotensin system in the acute renal decompensation that occasionally occurs in progressive systemic sclerosis.

Symposium on Renal Transplantation

Introduction The past decade has witnessed striking advances toward the successful achievement of organ transplantation, particularly in the area of renal transplantation. Of the many important factors that have contributed to such rapid progress, at least three can be identified whose contribution to the increasing success and application of renal transplantation would seem to have been particularly influential: (1) The nature, composition, or location of the renal transplantation antigens themselves may be such that they are happily and inherently less inductive of an immune response than those of certain other organ systems, ie, skin. In consequence, the immunological rejection of alien renal tissue by the host may have been fortuitously somewhat easier to control with available methods of immunosuppression. (2) The fortunate presence of paired healthy kidneys, one of which is not essential for life, has permitted the considered use of optimally viable organs from living volunteer donors. (3) The