Rose H. Mele

Transitory congenital neutropenia: a new syndrome.

Abstract 1.1. Two cases of transitory congenital neutropenia are described. In both instances neutropenia most likely was due to the transplacental passage of a neutropenic factor. 2.2. Both patients exhibited similar clinical and laboratory findings. The bone marrow in the leukopenic mothers as well as in the newborn infants showed hyperplasia and maturation arrest of the granulocytic series. In one case, however, the mothers serum contained a demonstrable leuko-agglutinin which could be transferred by transfusion to a normal person. The factor exhibited many characteristics of an antibody. No neutropenic factor was demonstrable in the mother in Case II. The neutropenia and the titer of the leukocyte agglutinin were unaffected by splenectomy. 3.3. The two cases herein reported represent examples of a syndrome apparently not previously described.

Studies on platelets. XXIV. Analysis of some platelet antigens by complement fixation test.

Conclusion and summary It is confirmed that platelets have organ specificity, possessing an antigen common to platelets of different species, as well as species specificity, since antiplatelet antibodies react more strongly with homologous than with heterologous platelet antigens.

Fibrinolysis II: Absence of Antibodies to Streptokinase Following Injection of Purified Human Plasmin in Rabbits.

Conclusions The results with the agar precipitation technic indicated the existence of multiple antigenic constituents of human plasmin, possibly due to contamination by other components of plasma. Our preparations of human plasmin. however, either contained no streptokinase or amounts of this agent insufficient to induce an antigenic response. Streptokinase represents a possible contaminant or constituent of plasmin. Thus, at least in our experimental condition, negative results are important as they eliminate one possible source of iso-antigenicity of human plasmin. Summary. Agar precipitation technic detected no antibodies against purified streptokinase in rabbits immunized with streptokinase-activated, purified human plasmin.

Fibrinolysis VI. Activity of Aspergillin O (Mold Fibrinolysin) in vitro.

Summary 1. Aspergillin O is a material obtained from cultures of Aspergillus oryzae B-1273 which, at high concentrations and in vitro, depletes slightly the activity of prothrombin and labile factor, accelerates slightly the clotting time of recalcified plasma and the partial thromboplastin time. At lower concentrations, it does not affect appreciably the activity or concentration of various factors or constants of the blood clotting process, while still exhibiting marked proteolytic, esterase and fibrinolytic activity. 2. Its activity is inhibited by addition of plasma or serum.