Rose Marie Reichle

Effect of renal revascularization by splenic artery implantation on experimental renovascular hypertension

Abstract The antihypertensive effect of implanting a branch of the splenic artery into the renal cortex of uninephric rats with renal artery stenosis is presented. Systolic blood pressure determinations were performed by Doppler auscultation over the ventral aspect of the tail distal to a sphygmomanometer cuff. Extrarenal arterial implantation into the ischemic renal cortex of the rat does exert a significant antihypertensive effect.

Promotion of experimental breast carcinoma in rats treated with extract of liver from rats with portacaval shunt

Liver homogenates or extracts of liver homogenates from rats in which portacaval shunt had been performed were found to have a significant growth‐promoting effect on 7,12 dimethyl (a) benzanthracene (DMBA)‐produced breast carcinoma in rats. Tumor potentiation was manifested by increased incidence of animals developing tumors, increased number of tumors, and increased tumor size, when compared with animals receiving injections of shunted or control liver. These observations suggest the existence of a tumor‐stimulating factor in liver from which portal blood has been completely and chronically diverted by portacaval shunt. The demonstration of tumor growth stimulating factor(s) present in shunted liver, together with previously reported observations of the modification of the growth of various types of tumors in animals with a portacaval shunt, suggests that the liver is capable of playing an important role in tumor‐host interactions. The portacaval shunt appears to be useful as a technique in elucidating ways that liver function may influence tumor growth.

Effect of fetal tissue on experimental (7,12-dimethylbenz[a]anthracene) breast cancer in rats

Abstract Treatment with small quantities of fetal tissue from randomly bred Sprague—Dawley rats can either potentiate or depress the development of DMBA-induced breast tumors in young adult female Holtzman rats. The difference between potentiation and suppression of tumors depended upon whether the fetal tissue had been killed (by freeze—thawing and homogenization), which potentiated tumor development, or whether a viable mince of fetal tissue had been used, which greatly suppressed tumor development and caused a high rate of tumor regression.