Rosemary O. Higgins

Anxiety and depression after coronary artery bypass graft surgery: most get better, some get worse.

Background To target interventions, patients at risk for poor outcomes after a cardiac event need to be identified. We investigated trajectories of anxiety and depression after coronary artery bypass graft surgery (CABGS) and identified patients at risk of persistent or worsening anxiety and depression. Methods A consecutive sample of 184 patients on the waiting list for CABGS at The Royal Melbourne Hospital completed self-report questionnaires before surgery, and at 2 and 6 months postsurgery. Anxiety and depression were measured using the Hospital Anxiety and Depression Scale. Growth mixture modelling identified trajectories of anxiety and depression. Results Two possible trajectories emerged for anxiety, whereas three trajectories emerged for depression. Most patients (92%) followed a trajectory of minor presurgical anxiety that remitted in 6 months after CABGS, with the remainder (8%) following a trajectory of major anxiety that remitted in the same period. Minor remitted depression was also common (72% patients). Two less common depression trajectories indicated worsening or unresolved depression. One trajectory began with major presurgical depression that partially remitted by 6 months (14% patients) and the other began with minor presurgical depression that worsened by 6 months (14% patients). Unpartnered patients, smokers, those with presurgical anxiety, high cholesterol, angina, more severe disease or having repeat CABGS were at increased risk for a poor depression trajectory. Conclusion Although initial anxiety and depression resolved or lessened for most patients, some patients experienced persistent or worsening depression after CABGS. Interventions can be targeted toward ‘at risk’ patients. Eur J Cardiovasc Prev Rehabil 15:434-440© 2008 The European Society of Cardiology

Trajectories and predictors of anxiety and depression in women during the 12 months following an acute cardiac event

OBJECTIVES Many previous investigations of the recovery of emotional well-being, particularly the resolution of depression, following an acute cardiac event assume that all patients follow a similar, linear trajectory. However, it is possible that there are different groups of patients who follow different trajectories. This study tested for multiple trajectories of anxiety and depression and identified the characteristics of patients most at risk for persistent or worsening anxiety and depression in the 12 months following their cardiac event. METHOD A consecutive sample of 226 women was interviewed following either acute myocardial infarction (AMI) or coronary artery bypass graft surgery (CABGS). The Hospital Anxiety and Depression Scale were administered on four occasions over 12 months. Growth curve and growth mixture modelling were used to identify trajectories of change and univariate tests were employed to establish predictors of each trajectory. RESULTS Most women began with relatively low levels of anxiety and/or depression that improved over the 12 month period (84% women showed this trajectory for anxiety, 89% for depression). A smaller group began with relatively high levels of anxiety and/or depression that worsened over time (16% for anxiety, 11% for depression). Patients in the latter group were more likely to report high levels of loneliness, have a first language other than English, perceive their cardiac disease as more severe (anxiety group only) and have diabetes (depression group only). Trajectories were non-linear, with most change occurring in the initial 2-month period. CONCLUSION Growth modelling techniques highlight that change in anxiety and depression following an acute event follows neither a single nor linear trajectory. Most women showed early resolution of anxiety and depression following their event, indicative of a normal bereavement or adjustment response. A minority of women reported worsening anxiety and/or depression in the year following their cardiac event, particularly those who lacked social support or were from non-English speaking backgrounds. Intervention studies to explore support options for these women are warranted, both prior to and following their event.

Causal attributions for coronary heart disease among female cardiac patients.

PURPOSE Beliefs about the etiology of coronary heart disease (CHD) can influence patient outcomes following an acute cardiac event. However, past research has focused predominantly on male patients. The present study investigated causal attributions and their associations with actual risk profiles in female cardiac patients. METHODS Female cardiac patients consecutively admitted to hospital after an acute myocardial infarction (AMI) or for coronary artery bypass graft surgery (CAGS) were interviewed in hospital at 2, 4, and 12 months postdischarge. RESULTS Among 260 women (mean age = 68.6, SD = 10.4), there was little correspondence between actual and perceived risk factors. Hypertension was least recognized: only 5% of the 180 women who had hypertension acknowledged it as a cause of their CHD. High cholesterol, obesity, and high-fat diet were also underacknowledged, with only 14%, 15%, and 17% of women with these risk factors implicating them in their CHD. A higher percentage, 44%, of smokers and 40% of women with a positive family history acknowledged these risk factors as a cause of their CHD. Women who had no idea about the cause of their CHD constituted 20%. There was little change in causal attributions over the 12-month study period and little apparent impact of cardiac rehabilitation (CR) program attendance on causal beliefs. CONCLUSIONS Women were more likely to attribute their CHD to smoking or positive family history than to other major modifiable risk factors. The lack of correspondence between actual and perceived risk factors and the lack of impact of CR attendance on causal attributions highlight the need for personalized advice and support regarding risk factor modification.

Health related quality of life trajectories and predictors following coronary artery bypass surgery

BackgroundMany studies have demonstrated that health related quality of life (HRQoL) improves, on average, after coronary artery bypass graft surgery (CABGS). However, this average improvement may not be realized for all patients, and it is possible that there are two or more distinctive groups with different, possibly non-linear, trajectories of change over time. Furthermore, little is known about the predictors that are associated with these possible HRQoL trajectories after CABGS.Methods182 patients listed for elective CABGS at The Royal Melbourne Hospital completed a postal battery of questionnaires which included the Short-Form-36 (SF-36), Profile of Mood States (POMS) and the Everyday Functioning Questionnaire (EFQ). These data were collected on average a month before surgery, and at two months and six months after surgery. Socio-demographic and medical characteristics prior to surgery, as well as surgical and post-surgical complications and symptoms were also assessed. Growth curve and growth mixture modelling were used to identify trajectories of HRQoL.ResultsFor both the physical component summary scale (PCS) and the mental component summary scale (MCS) of the SF-36, two groups of patients with distinct trajectories of HRQoL following surgery could be identified (improvers and non-improvers). A series of logistic regression analyses identified different predictors of group membership for PCS and MCS trajectories. For the PCS the most significant predictors of non-improver membership were lower scores on POMS vigor-activity and higher New York Heart Association dyspnoea class; for the MCS the most significant predictors of non-improver membership were higher scores on POMS depression-dejection and manual occupation.ConclusionIt is incorrect to assume that HRQoL will improve in a linear fashion for all patients following CABGS. Nor was there support for a single response trajectory. It is important to identify characteristics of each patient, and those post-operative symptoms that could be possible targets for intervention to improve HRQoL outcomes.

Expressed preferences for health education of patients after percutaneous coronary intervention

Background Percutaneous coronary intervention patients may require further education to increase their uptake of lifestyle change. Little is known, however, about their preferences for health education. This study aimed to investigate percutaneous coronary intervention patients’ preferences regarding information provision and to identify patient characteristics associated with specific preferences. Design and methods A consecutive series of eligible patients was recruited from three metropolitan hospitals in Melbourne, Australia after their first percutaneous coronary intervention. Structured telephone interviews were conducted with 218 patients shortly after discharge from hospital. Patient preferences for source and format of information about both heart disease and lifestyle change were ascertained. Data regarding demographic characteristics and rehabilitation attendance were also collected. Results Cardiac rehabilitation programme staff were the most frequently nominated preferred source for information delivery. Cardiac rehabilitation was also the most frequently nominated preferred format for information delivery. Half the patients nominated alternative formats, most commonly individual consultation with a health professional and self-education. Not surprisingly, patients who preferred alternatives to group cardiac rehabilitation were significantly less likely to attend rehabilitation. Conclusions It is important to cater for patients who express a desire for alternative information formats. A flexible model of cardiac rehabilitation delivery which incorporates non-group alternatives would meet the needs of these patients.

Are poor health behaviours in anxious and depressed cardiac patients explained by sociodemographic factors

Introduction: While there is evidence of poor health behaviours in anxious and depressed cardiac patients, it is possible that sociodemographic factors explain these associations. Few previous studies have adequately controlled for confounders. The present study investigated health behaviours in anxious and depressed cardiac patients, while accounting for sociodemographic confounders. Method: A consecutive sample of 275 patients admitted to hospital after acute myocardial infarction (32%) or for coronary bypass surgery (40%) or percutaneous coronary intervention (28%) was interviewed six weeks after hospital discharge. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS). Smoking, physical activity, alcohol intake and dietary fat intake were assessed by self-report. Backward stepwise logistic regression was used to identify the factors independently associated with anxiety and depression. Results: In total, 41 patients (15.2%) were ‘depressed’ (HADS-D ≥8) while 68 (25.2%) were ‘anxious’ (HADS-A ≥8). Depressed patients reported higher rates of smoking (χ2 = 4.47, p = 0.034), lower physical activity (F = 8.63, p < 0.004) and higher dietary fat intake (F = 7.22, p = 0.008) than non-depressed patients. Anxious patients reported higher smoking rates (χ2 = 5.70, p = 0.024) and dietary fat intake (F = 7.71, p = 0.006) than non-anxious patients. In multivariate analyses, an association with depression was retained for both diet and physical activity, and an association with anxiety was retained for diet. Low social support and younger age were significant confounders with depression and anxiety respectively. Conclusions: While the high smoking rates evidenced in anxious and depressed patients were explained by sociodemographic factors, their poor diet and low physical activity (depressed patients only) were independent of these factors. Given the impact of lifestyle modification on survival after a cardiac event, anxious and depressed patients should be a priority for cardiac rehabilitation and other secondary prevention programmes.

Reduction in 2-year recurrent risk score and improved behavioral outcomes after participation in the "Beating Heart Problems" self-management program: results of a randomized controlled trial.

PURPOSE: While behavior change can improve risk factor profiles and prognosis after an acute cardiac event, patients need assistance to achieve sustained lifestyle changes. We developed the “Beating Heart Problems” cognitive-behavioral therapy and motivational interviewing program to support patients to develop behavioral and cognitive self-management skills. We report the results of a randomized controlled trial of the program. METHODS: Patients (n = 275) consecutively admitted to 2 Melbourne hospitals after acute myocardial infarction (32%), coronary artery bypass graft surgery (40%), or percutaneous coronary intervention (28%) were randomized to treatment (T; n = 139) or control (C; n = 136). T group patients were invited to participate in the 8-week group-based program. Patients underwent risk factor screening 6 weeks after hospital discharge (before randomization) and again 4 and 12 months later. At both the followups, T and C groups were compared on 2-year risk of a recurrent cardiac event and key behavioral outcomes, using both intention-to-treat and “completers only” analyses. RESULTS: Patients ranged in age from 32 to 75 years (mean = 59.0 years; SD – 9.1 years). Most patients (86%) were men. Compared with the C group patients, T group patients tended toward greater reduction in 2-year risk, at both the 4- and 12-month followups. Significant benefits in dietary fat intake and functional capacity were also evident. CONCLUSIONS: The “Beating Heart Problems” program showed modest but important benefit over usual care at 4 and, to a lesser extent, 12 months. Modifications to the program such as the inclusion of booster sessions and translation to online delivery are likely to improve outcomes.

An integrated secondary prevention group programme reduces depression in cardiac patients

Objective Depression is common following an acute cardiac event and can occur at a time when behaviour change is strongly recommended to reduce the risk of further cardiovascular events. The ‘Beating Heart Problems’ programme was designed to support cardiac patients in behaviour change and mood management. Methods The programme was based on cognitive behaviour therapy and motivational interviewing. A randomized controlled trial (RCT) comparing the 8-week group programme with usual care was undertaken between 2007 and 2010. All patients attended a hospital-based clinic for assessment of physiological risk factors at baseline (6 weeks after their acute event), and at 4- and 12-month follow up. Psychological and behavioural indicators were assessed by self-report questionnaires. Of the 275 patients enrolled into the RCT, 42 (15%) had Beck Depression Inventory-II scores >13 at baseline. Treatment and control group comparisons were undertaken for this subgroup, using growth curve modelling and testing for group differences over time in psychological, physiological, health behaviour, and self-efficacy measures. Results Significantly greater improvements (p < 0.01) in depression symptoms and self-rated health were reported for the intervention group, as well as significantly larger gains in confidence in managing depression (p < 0.05) and anger (p < 0.01). Trends (0.05 < p < 0.10) for larger treatment group improvements were also seen for anxiety symptoms and confidence in managing anxiety. Conclusion A group secondary-prevention programme that integrates behavioural and mood management strategies leads to decreased depression, increased confidence, and improved health perceptions in depressed cardiac patients.

Predicting mortality 12 years after an acute cardiac event: comparison between inhospital and 2-month assessment of depressive symptoms in women.

PURPOSE: Research demonstrates that depression at the time of a cardiac event predicts early mortality. However, the best time for depression screening is unknown. We investigated the prognostic importance of inhospital and 2-month depressive symptoms in predicting 12-year mortality in female cardiac patients. METHODS: A consecutive series of 170 women admitted to hospital after acute myocardial infarction or for coronary artery bypass graft surgery completed the Hospital Anxiety and Depression Scale inhospital and 2 months later. Hospital Anxiety and Depression Scales depression subscale scores of 4 to 7 were classified as “mild” depressive symptoms and 8+ as “moderate/severe” depressive symptoms. Mortality was tracked through the Australian National Death Index and other sources. RESULTS: One hundred sixty-three (96%) of the 170 women were successfully tracked after 12 years. Of these women, 136 (83%) completed the depression subscale of the Hospital Anxiety and Depression Scale at both assessments and were included in the analyses. Over 12 years, 45 (33%) women died. Using logistic regression and controlling for age, disease severity, and diabetes, mild inhospital depression predicted mortality (P = .02), whereas moderate/severe inhospital depression did not (P = .14). At 2 months, moderate/severe depression predicted mortality (P = .05), whereas mild depression did not (P = .09). Half the patients (49%) changed depression class by the 2-month assessment. The death rate was highest (64%) in those whose mild inhospital depressive symptoms increased to moderate/severe and lowest (14%) in those whose moderate/severe inhospital symptoms remitted. CONCLUSIONS: Mild inhospital depression and moderate/severe 2-month depression were predictive of 12-year deaths. The findings suggest a prognostic benefit in undertaking repeat depression screening 2 months after an acute cardiac event.

Change in Women's Dietary Fat Intake Following an Acute Cardiac Event: Extent, Predictors and Comparison with Non-Cardiac Australian Women and Older Adults

Background: Cardiac patients are encouraged to reduce their dietary fat intake, yet few studies have assessed fat intake in female cardiac patients. Aim: We assessed changes in fat intake for female cardiac patients at four occasions during the first year following their event, and compared it with fat intake for a non-cardiac sample. Methods: The Short Fat Questionnaire (SFQ) was administered to 239 women aged 36 to 84 years consecutively admitted to four hospitals at the time of an acute event. Mplus was used to analyse change over time in SFQ scores and to identify predictors of change. Mean SFQ scores were compared with those for a sample of randomly selected Australian women and older adults. Results: Mean SFQ scores decreased substantially during the first two months (t(139) = 8.374, p < 0.001), then increased over the subsequent 10 months (t(146) = 4.656, p < 0.001). By 12 months, SFQ scores remained significantly lower than at baseline. Older women and those with hypertension showed less reduction in fat intake. At all four time-points, mean SFQ scores were significantly lower than those reported for other Australian women and older adults. Conclusion: Even prior to their event, female cardiac patients reported lower fat intake than other Australian women and older adults, but showed partial deterioration in adherence following convalescence. Future studies could investigate options for assisting patients to sustain dietary changes, with attention to older patients and those with hypertension.