Rramaswamy Ravikumar

Preparation, characterization, and in vitro diffusion study of nonwoven electrospun nanofiber of curcumin-loaded cellulose acetate phthalate polymer

Highlights • Nonwoven nano fibers of cellulose acetate phthalate were developed successfully.• The fibers were loaded with curcumin and its in vitro transdermal release property was studied.• The as-prepared fibers demonstrated controlled in vitro transdermal delivery of CUR for up to 24 h.

Lipid-polymer hybrid nanoparticle-mediated therapeutics delivery: Advances and challenges

With rapid advances in nanomedicine, lipid-polymer hybrid nanoparticles (LPHNPs) have emerged as promising nanocarriers for several biomedical applications, including therapeutics delivery and biomedical imaging. Significant research has been dedicated to biomimetic or targeting functionalization, as well as controlled and image-guided drug-release capabilities. Despite this research, the clinical translation of LPHNP-mediated therapeutics delivery has progressed incrementally. In this review, we discuss the recent advances in and challenges to the development and application of LPHNPs, present examples to demonstrate the advantages of LPHNPs in therapeutics delivery and imaging applications, and discuss the translational obstacles to LPHNP technology.