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Featured researches published by Rudolf de Châtel.


Life Sciences | 1998

Interactions between ouabain, atrial natriuretic peptide, angiotensin-II and potassium: Effects on rat zona glomerulosa aldosterone production

Katalin Sz. Szalay; Monika Beck; Miklós Tóth; Rudolf de Châtel

The effects of ouabain, atrial natriuretic peptide, angiotensin-II and potassium on aldosterone production by collagenase dispersed rat zona glomerulosa cells were studied. A-II and 10(-4) M ouabain-induced increases in aldosterone production was inhibited by 10(-9) M ANP at all potassium concentrations examined. 10(-4) M ouabain inhibited the A-II induced increase in aldosterone production at all potassium concentrations. The degree of this inhibition was smaller at higher potassium levels. Ouabain enhanced the inhibitory effect of ANP on A-II-induced aldosterone synthesis at all potassium concentrations. Interactions between A-II, ANP, ouabain and potassium may be of physiological significance in the regulation of aldosterone secretion.


American Journal of Hypertension | 1998

Relationship Between Blood Pressure Variability and Serum Dehydroepiandrosterone Sulfate Levels

István Barna; Tibor Fehér; Rudolf de Châtel

Decreased diurnal blood pressure variability and low dehydroepiandrosterone sulfate (DHEAS) levels are important predictors of cardiovascular morbidity and mortality. The aim of the study was to determine the relationship between DHEAS levels and diurnal blood pressure variability in normotensive subjects and in patients with essential hypertension of both genders. An ambulatory blood pressure monitor (ABPM), Meditech O2 device and radioimmunoassay were used for ambulatory blood pressure monitoring and the determination of DHEAS levels, respectively. A close correlation (P < .001) was found between the diurnal indices and plasma DHEAS levels of the 387 subjects (86 normotensive and 301 hypertensive patients) participating in the study. Decreased plasma DHEAS levels were associated in both genders, and in both normotensive and hypertensive patients with significantly (P < .001) lower diurnal indices. There was a close correlation (P < .001) between the age-related decrease in plasma DHEAS levels and diurnal indices in both genders. Systolic and diastolic blood pressure variability changed parallel to plasma DHEAS levels in both genders, whether hypertension was present or not. Additional investigations are needed to find out whether reduced DHEAS levels play a role in decreased diurnal indices or whether both can be traced back to one and the same cause.


Journal of Cardiovascular Pharmacology | 2004

Effects of experimental diabetes on endothelin-induced ventricular arrhythmias in dogs

Ildikó Pósa; Ferenc Horkay; Leila Seres; Réka Skoumal; Tìmea Kovàts; Éva Balogh; Rudolf de Châtel; Miklós Tóth; Erzsébet Kocsis

Endothelin-1 (ET-1) is known to have a direct arrhythmogenic effect in the mammalian heart. Diabetes mellitus is accompanied by a series of endothelial and cardiac disfunctions; however, little is known about ET-1-induced direct arrhythmias in diabetes mellitus. Therefore, we infused ET-1 (33 pmol/min) into the left anterior descending coronary artery of 28 mongrel dogs, and measured basic hemodynamic parameters, coronary flow and an electrocardiogram. Diabetes mellitus was induced by alloxan (Group 4) and experiments were carried out 8 weeks later. Metabolically healthy dogs served as controls (Group 2). In a further control group, local hyperglycemia was induced by intracoronary glucose infusion (Group 3). ET-1 infusion induced prolongation of the QT-time and frequency-adjusted QT-time in all groups. Other electrophysiological parameters were comparable between the groups. This was followed by the occurence of ventricular premature beats, coupled extra-beats and later sustained ventricular tachycardia. Most of the experiments were terminated by ventricular fibrillation. The onset of arrhythmias was shorter in diabetic dogs as compared with control and locally hyperglycemic animals (18 ± 8 minutes versus 24 ± 8 minutes and 30 ± 28 minutes, P < 0.05). However, there was no difference in the number of ventricular fibrillations, and the total elapsed time until the termination of the experiments. Therefore, the diabetic heart seems to be more prone to ET-1-induced arrhythmias and this is probably not a result of locally high glucose concentrations.


Archive | 1992

Hungarian Medical Education: Present Problems and Future Plans for Eastern European Medical Schools

Rudolf de Châtel

The first university in Hungary was established in the 14th century; however, it was soon destroyed during the Turkish occupation, which lasted more than 150 years. The university was re-established in the 17th century, and in 1769 the Faculty of Medicine was set up by Maria Theresia, Queen of Hungary and Empress of Austria. It was not until the beginning of the 19th century, however, that the University could be moved to the capital because the destruction of the country by the Turks had been so vast.


Journal of Hepatology | 1996

Platelet serotonin (5-HT) content is decreased in patients with alcoholic liver cirrhosis, but elevated in Gilbert's syndrome

Dóra Borcsiczky; Ferenc Szalay; Kornélia Tekes; József Tarcali; K. Magyar; Rudolf de Châtel


Life Sciences | 2004

Endogenous ouabain-like factor (OLF) secretion is modulated by nicotinic mechanisms in rat adrenocortical cells

Monika Göõz; Miklós Tóth; Olli Vakkuri; Pal Gooz; Adam J. Smolka; Rudolf de Châtel; Katalin Sz. Szalay


Orvosi Hetilap | 1994

24 órás ambuláns vérnyomásmonitorozó készülék összehasonlító vizsgálata standard zéró és random zéró vérnyomásmérövel.

A. Tislér; István Barna; Rudolf de Châtel


American Journal of Hypertension | 2003

P-73: Feasibility and efficacy of telemedicinal self blood pressure monitoring in the management of diabetic or renal patients

Andrś Tislér; B. Fekete; György Deák; Rudolf de Châtel


Archive | 1994

24 órás ambuláns vérnyomásmonitorozó készülék összehasonlító vizsgálata standard zéró és random zéró vérnyomásmérővel [Comparative study of 24-hour ambulatory blood pressure monitors with standard zero and random zero sphygmomanometers]

A. Tislér; István Barna; Rudolf de Châtel


Orvosi Hetilap | 1990

The role of exchangeable sodium content of the body in cases of hypertension of various etiology

Rudolf de Châtel; István Barna; Miklós Tóth; A. Tislér; M. Herendi; I. Krasznai

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Katalin Sz. Szalay

Hungarian Academy of Sciences

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B. Fekete

Semmelweis University

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