Rudolf W. Hendriks | Researchain

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Featured researches published by Rudolf W. Hendriks.

Genomics | 1992

Characterization of a highly polymorphic region near the first exon of the human MAOA gene containing a GT dinucleotide and a novel VNTR motif.

Hinds H; Rudolf W. Hendriks; Ian Craig; Zheng-Yi Chen

The genes encoding the A and B forms of the human monoamine oxidase enzymes (MAOA and MAOB) are localized at Xp11.23-Xp11.4. We report the characterization of a highly informative polymorphic region within a 2.9-kb cloned fragment containing the first exon of the MAOA gene. The polymorphic region consists of a GT microsatellite directly adjacent to an imperfectly duplicated novel 23-bp VNTR motif. DNA sequencing within and flanking the repeated segment allowed the design of specific amplification primers. In 56 unrelated females, 15 different alleles were identified with sizes ranging from 285 to 388 bp. The alleles differed in both the number of dinucleotide and the number of VNTR repeats, yielding a highly informative polymorphic marker locus with a calculated heterozygosity value of 75%.

Nature Genetics | 1992

Isolation and characterization of a candidate gene for Norrie disease

Zheng-Yi Chen; Rudolf W. Hendriks; Jobling Ma; John Powell; Xandra O. Breakefield; Katherine B. Sims; Ian Craig

Human Molecular Genetics | 1992

An X chromosome inactivation assay based on differential methylation of a CpG island coupled to a VNTR polymorphism at the 5′ end of the Monoamine Oxidase A gene

Rudolf W. Hendriks; Zheng-Yi Chen; Hinds H; Ruud K. B. Schuurman; Ian Craig

European Journal of Immunology | 1990

Evidence that in X-linked immunodeficiency with hyperimmunoglobulinemia M the intrinsic immunoglobulin heavy chain class switch mechanism is intact.

Rudolf W. Hendriks; Margriet E. M. Kraakman; Ian Craig; Teresa Espanol; Ruud K. B. Schuurman

Genomics | 1993

Norrie disease gene : characterization of deletions and possible function

Zheng-Yi Chen; Elisabeth M. Battinelli; Rudolf W. Hendriks; John Powell; H. Middleton-Price; K.B. Sims; Xandra O. Breakefield; Craig Iw

European Journal of Immunology | 1992

Immunoglobulin x light chain germ‐line transcripts in human precursor B lymphocytes

Allan Thompson; Erik Timmers; Marcel J. H. Kenter; Margriet E. M. Kraakman; Rudolf W. Hendriks; Ruud K. B. Schuurman

Genomics | 1992

The hypervariable DXS255 locus contains a LINE-1 repetitive element with a CpG island that is extensively methylated only on the active X chromosome

Rudolf W. Hendriks; Hinds H; Zheng-Yi Chen; Ian Craig

European Journal of Immunology | 1993

Diversity of immunoglobulin χ light chain gene rearrangements and evidence for somatic mutation in VχIV family gene segments in X-linked agammaglobulinemia

Erik Timmers; Marcel M. Hermans; Margriet E. M. Kraakman; Rudolf W. Hendriks; Ruud K. B. Schuurman

European Journal of Immunology | 1990

Severe combined immunodeficiency in man with an absence of immunoglobulin gene rearrangements but normal T cell receptor assembly.

Allan Thompson; Rudolf W. Hendriks; Margriet E. M. Kraakman; Frits Koning; Renée Langlois-Van Den Bergh; Jaak M. Vossen; Corry Weemaes; Ruud K. B. Schuurman

Immunodeficiency | 1993